Nifedipine loaded-polymeric microspheres: preparation and physical characteristics

Guyot, M.; Fawaz, F

doi:10.1016/s0378-5173(98)00253-1

Cited by 68 publications

(36 citation statements)

References 22 publications

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“…EC reduces the drug release due to a reduction in the penetration of the solvent molecules into the system because of the hydrophobic nature of ethylcellulose present on the surface of the tablet, i.e. the rate of release is controlled by the permeability of matrix structure (24). As the proportion of ethylcellulose increase, the release process of propranolol hydrochloride decreares (Fig.…”

Section: Resultsmentioning

confidence: 99%

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Patra¹,

Kumar²,

Pandit³

et al. 2007

Acta Pharmaceutica

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Section: Resultsmentioning

confidence: 99%

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Patra¹,

Kumar²,

Pandit³

et al. 2007

Acta Pharmaceutica

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“…PLGA and GB were dissolved in 25 ml of solvent mixture containing methanol to dichloromethane in a ratio 2:1, using a vortex shaker to form a homogeneous solution of drug and polymer. This homogeneous solution was added slowly to 120 ml of aqueous surfactant solution containing 0.5 % w/v polyvinyl alcohol and polysorbate-80, and homogenised using a high pressure homogenizer (Ika, Japan) to obtain an emulsion [13][14][15]. The emulsion formed was stirred with a laboratory magnetic stirrer (Remi, India) for 5 h at 25 ºC followed by centrifugation (Remi, India) for 22 min.…”

Section: Methods Of Preparation Of Gb-loaded Npsmentioning

confidence: 99%

Preparation and Evaluation of Glibenclamide-Loaded Biodegradable Nanoparticles

Behera¹,

Sahoo²

2012

Trop. J. Pharm Res

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“…The thermogram obtained by DTA and DSC can be observed for broadening, shifting and appearance of new peaks or disappearance of certain peaks. Absence of the drug melting peak of the crystal structure in the DSC thermogram is a sign of molecularly dispersed drug within the polymer (74)(75)(76). Changes in weight loss can also provide supporting evidence for the formation of inclusion complexes (4).…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

Cyclodextrin based nanosponges for pharmaceutical use: A review

Tejashri¹,

Amrita²,

Darshana³

2013

Acta Pharmaceutica

197

100

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Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. Well--known examples of nanosponges are titanium-based nanosponges (1), silicon nano- Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. These nano-sized colloidal carriers have been recently developed and proposed for drug delivery, since their use can solubilize poorly water-soluble drugs and provide prolonged release as well as improve a drug's bioavailability by modifying the pharmacokinetic parameters of actives. Development of nanosponges as drug delivery systems, with special reference to cyclodextrin based nanosponges, is presented in this article. In the current review, attempts have been made to illustrate the features of cyclodextrin based nanosponges and their applications in pharmaceutical formulations. Special emphasis has been placed on discussing the methods of preparation, characterization techniques and applications of these novel drug delivery carriers for therapeutic purposes. Nanosponges can be referred to as solid porous particles having a capacity to load drugs and other actives into their nanocavity; they can be formulated as oral, parenteral, topical or inhalation dosage forms. Nanosponges offer high drug loading compared to other nanocarriers and are thus suitable for solving issues related to stability, solubility and delayed release of actives. Controlled release of the loaded actives and solubility enhancement of poorly water-soluble drugs are major advantages of nanosponge drug delivery systems.

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Nifedipine loaded-polymeric microspheres: preparation and physical characteristics

Cited by 68 publications

References 22 publications

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Preparation and Evaluation of Glibenclamide-Loaded Biodegradable Nanoparticles

Cyclodextrin based nanosponges for pharmaceutical use: A review

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