Nifedipine treatment in preeclampsia reverts the increased erythrocyte aggregation to normal

Tranquilli, Andrea Luigi; Garzetti, G. G.; Tommaso, G. De; Boemi, Massimo; Lucino, E; Fumelli, P.; Romaninï, Carlo

doi:10.1016/s0002-9378(12)80016-0

Cited by 14 publications

(3 citation statements)

References 10 publications

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“…Others did not observe any significant deformability alteration in PE [34,35]. Tranquilli et al reported increased erythrocyte aggregation in PE [22], while other authors did not observe significant deterioration [36,37]. In line with our observations, Heilmann et al found enhanced RBC aggregation and reduced deformability by high shear stress in patients with severe PE, suggesting that hemorheological parameters play an important role in the microcirculation of the intervillous space of the placenta [17].…”

Section: Previous Data Concerning Rbc Propertiessupporting

confidence: 89%

“…In PE, changes of cellular factors are suggested to be more responsible for the pronounced aggregation propensity [10]. Increased RBC aggregation can be attributed to the reduced sialic acid content of the cell membrane that weakens repulsive forces [21] and conformational changes of the membrane enhancing erythrocyte aggregation [22]. A most recent study also confirmed decreased erythrocytic membrane anionic charge due to the reduced sialic acid content of the erythrocyte cell membrane in women with PE/eclampsia, which may be responsible for the aggregation of erythrocytes in these conditions [23].…”

Section: Rbc Aggregationmentioning

confidence: 99%

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Peripartum Investigation of Red Blood Cell Properties in Women Diagnosed with Early-Onset Preeclampsia

Csiszar

Galos

Funke

et al. 2021

Cells

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We investigated peripartum maternal red blood cell (RBC) properties in early-onset preeclampsia (PE). Repeated blood samples were taken prospectively for hemorheological measurements at PE diagnosis (n = 13) or during 26–34 weeks of gestation in healthy pregnancies (n = 24), then at delivery, and 72 h postpartum. RBC aggregation was characterized by M index (infrared light transmission between the aggregated RBCs in stasis) and aggregation index (AI—laser backscattering from the RBC aggregates). We observed significantly elevated RBC aggregation (M index = 9.8 vs. 8.5; AI = 72.9% vs. 67.5%; p < 0.001) and reduced RBC deformability in PE (p < 0.05). A positive linear relationship was observed between AI and gestational age at birth in PE by regression analysis (R2 = 0.554; p = 0.006). ROC analysis of AI showed an AUC of 0.84 (0.68–0.99) (p = 0.001) for PE and indicated a cutoff of 69.4% (sensitivity = 83.3%; specificity = 62.5%), while M values showed an AUC of 0.75 (0.58–0.92) (p = 0.019) and indicated a cutoff of 8.39 (sensitivity = 90.9% and specificity = 50%). The predicted probabilities from the combination of AI and M variables showed increased AUC = 0.90 (0.79–1.00) (p < 0.001). Our results established impaired microcirculation in early-onset PE manifesting as deteriorated maternal RBC properties. The longer the pathologic pregnancy persists, the more pronounced the maternal erythrocyte aggregation. AI and M index could help in the prognostication of early-onset PE, but further investigations are warranted to confirm the prognostic role before the onset of symptoms.

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Section: Previous Data Concerning Rbc Propertiessupporting

confidence: 89%

Section: Rbc Aggregationmentioning

confidence: 99%

Peripartum Investigation of Red Blood Cell Properties in Women Diagnosed with Early-Onset Preeclampsia

Csiszar

Galos

Funke

et al. 2021

Cells

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“…Volume 11 • Number 2 aggregation, (48) improved renal function (49) and increased urinary excretion of prostacyclin metabolites. (50) Despite causing vasodilatation, these agents seldom cause a problematic tachycardia.…”

Section: Autumn 2014mentioning

confidence: 99%

Treatment of hypertension during pregnancy

Hall

2017

SAHJ

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68eclampsia. Amongst these women, pulmonary oedema (28%), intracranial haemorrhage (23%), cerebral oedema resulting in coning (9%) and brain death following a hypoxic event (7%) were the most frequently recorded final causes of death. Although most of these deaths occurred in tertiary and regional hospitals, hypertensive deaths still comprised 15% of all maternal deaths at Community Health Centres, emphasising the importance of correct initial management at all levels of care.(6) With regards to the timing of the emergency event related to hypertension, 28% (n=191) occurred in the postpartum period. An important aspect of the Saving Mothers report is the attention paid by assessors to avoidable factors, missed opportunities and sub-standard care. In the most recent report, health worker orientated emergency management problems were noted in 42% of hypertensive deaths at Community Health Centres and District hospitals, 33% at Regional hospitals and 17% at Tertiary hospitals.(6) Not only is the mortality associated with hypertensive disorders in pregnancy high, but these conditions are a frequent source of significant morbidity. (8,9) Cases with Severe Acute Maternal Morbidity (SAMM) share many characteristics with maternal deaths. (10) Therefore understanding and managing SAMM also helps to decrease or prevent maternal mortality.

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From Clinical Research to Clinical Practice in Obstetrics and Gynecology

Giannubilo

Carpini

Ciavattini

2020

The First Outstanding 50 Years of “Università Politecnica Delle Marche”

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Nifedipine treatment in preeclampsia reverts the increased erythrocyte aggregation to normal

Cited by 14 publications

References 10 publications

Peripartum Investigation of Red Blood Cell Properties in Women Diagnosed with Early-Onset Preeclampsia

Peripartum Investigation of Red Blood Cell Properties in Women Diagnosed with Early-Onset Preeclampsia

Treatment of hypertension during pregnancy

From Clinical Research to Clinical Practice in Obstetrics and Gynecology

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