Nifedipine versus terbutaline for tocolysis in external cephalic version

Ismail, Napsiah; Ibrahim, Mohd Faisal; Naim, Norzilawati Mohd; Mahdy, Zaleha Abdullah; Jamil, M. A.; Razi, Zainul Rashid Mohd

doi:10.1016/j.ijgo.2008.04.010

Cited by 18 publications

(32 citation statements)

References 25 publications

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“…Our findings are consistent with previous studies that have shown that terbutaline10–12 and salbutamol13–15 are effective tocolytic agents accompanied by side effects. These studies show that beta-adrenergic agonists are more effective compared to calcium channel blockers;10–1214 however, their significant side effects have limited use in practice.…”

Section: Discussionsupporting

confidence: 93%

“…These studies show that beta-adrenergic agonists are more effective compared to calcium channel blockers;10–1214 however, their significant side effects have limited use in practice. On the other hand, these agents do not decrease the neonatal mortality and morbidity associated with PTL.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the popularity of these agents as first-line tocolytic agents has decreased 1617. Nevertheless, these agents are recommended as first-line tocolytic agents because of their efficacy 1214…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that both subcutaneous terbutaline10–12 and intravenous salbutamol13–15 are effective tocolytic agents for patients with PTL. However, no study has compared the effects of these two agents until now.…”

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confidence: 99%

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Terbutaline versus salbutamol for suppression of preterm labor: a randomized clinical trial

Motazedian

Ghaffarpasand

Mojtahedi

et al. 2010

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVE:Preterm labor (PTL) is a common medical problem during pregnancies and is associated with neonatal mortality and morbidity. Beta-adrenergic agonists are among the most commonly used tocolytic agents. The aim of this study was to compare the effectiveness, safety and adverse effects of terbutaline with those of salbutamol in the prolongation of pregnancy beyond 48 hours and until 37 weeks of gestation.PATIENTS AND METHODS:Two hundred women with PTL were randomly assigned to receive subcutaneous terbutaline (250 μg) or intravenous salbutamol (0.1 mg) followed by oral terbutaline (20 mg/d) or oral salbutamol (24 mg/d) as maintenance. The efficacy, side effects and complications after 48 hours and until 37 weeks of gestation were analyzed and compared.RESULTS:There was no significant difference between the two groups in success rate within 48 hours (P=.091). Gestational age at delivery (P=.031) and the number of days for which the gestation was prolonged (P=.024) were significantly higher in those receiving terbutaline. Adverse effects, including tachycardia (P=.007) and anxiety (P=.006), were experienced more in the salbutamol group. Birth weight was significantly lower in the salbutamol group (P=.001).CONCLUSION:Terbutaline provided more effective tocolysis with fewer adverse effects and a better neonatal outcome. However, terbutaline and salbutamol are equally effective in the first 48 hours.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Terbutaline versus salbutamol for suppression of preterm labor: a randomized clinical trial

Motazedian

Ghaffarpasand

Mojtahedi

et al. 2010

Annals of Saudi Medicine

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“…This retrospective review aimed to analyse the outcome following successful ECV in our hospital. The success rate of ECV over these three years was 51.4%, which has improved compared to those reported in previous local studies [13, 14]. Hofmeyr et al demonstrated a similar success rate of ECV (40–50%) in routine clinical practice [15].…”

Section: Discussionmentioning

confidence: 56%

Successful External Cephalic Version: Factors Predicting Vaginal Birth

Lim

Ali³

et al. 2014

The Scientific World Journal

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Purpose. To determine the maternal and fetal outcomes of successful external cephalic version (ECV) as well as factors predicting vaginal birth. Methods. The ECV data over a period of three years at Universiti Kebangsaan Malaysia Medical Centre (UKMMC) between 1 September 2008 and 30 September 2010 was reviewed. Sixty-seven patients who had successful ECV were studied and reviewed for maternal, fetal, and labour outcomes. The control group comprised patients with cephalic singletons of matching parity who delivered following the index cases. Results. The mean gestational age at ECV was 263 ± 6.52 days (37.5 weeks ± 6.52 days). Spontaneous labour and transient cardiotocographic (CTG) changes were the commonest early adverse effects following ECV. The reversion rate was 7.46%. The mean gestational age at delivery of the two groups was significantly different (P = 0.000) with 277.9 ± 8.91 days and 269.9 ± 9.68 days in the study group and control groups, respectively. The study group needed significantly more inductions of labour. They required more operative deliveries, had more blood loss at delivery, a higher incidence of meconium-stained liquor, and more cord around the neck. Previous flexed breeches had a threefold increase in caesarean section rate compared to previous extended breeches (44.1% versus 15.2%, P = 0.010). On the contrary, an amniotic fluid index (AFI) of 13 or more is significantly associated with a higher rate of vaginal birth (86.8% versus 48.3%, P = 0.001). Conclusions. Patients with successful ECV were at higher risk of carrying the pregnancy beyond 40 weeks and needing induction of labour, with a higher rate of caesarean section and higher rates of obstetrics complications. Extended breech and AFI 13 or more were significantly more likely to deliver vaginally postsuccessful ECV. This additional information may be useful to caution a patient with breech that ECV does not bring them to behave exactly like a normal cephalic, so that they have more realistic expectations. However, these predictive factors needed further confirmation and hopefully, in the future, they would be able to further enhance counselling prior to ECV.

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