NIFT-P: Are they indolent tumors? Results of a multi-institutional study

Chéreau, Nathalie; Greilsamer, Tristan; Mirallié, Éric; Sadowski, Samira M.; Pusztaszeri, Marc; Triponez, Frédéric; Baud, Grégory; Pattou, François; Christou, Niki; Mathonnet, Muriel; Brunaud, Laurent; Santucci, Nicolas; Goudet, P.; Guérin, Carole; Sébag, F.; Donatini, Gianluca; Kraimps, Jean‐Louis; Tissier, Frédérique; Lussey-Lepoutre, Charlotte; Leenhardt, Laurence; Ménégaux, Fabrice

doi:10.1016/j.surg.2018.04.089

Cited by 16 publications

(7 citation statements)

References 22 publications

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“…As for presentation, 86.6% of our cases were symptomatic ( Table 4 ), in agreement with others where 77.4% were symptomatic [16] . Likewise, 93.3% of our sample were euthyroid ( Table 4 ), concurring with others where 92.8% of cases were euthyroid [17] .…”

Section: Discussionsupporting

confidence: 92%

What you see might not be what you get: Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Hassan

Ansari

Baba

et al. 2022

International Journal of Surgery Case Reports

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Section: Discussionsupporting

confidence: 92%

What you see might not be what you get: Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Hassan

Ansari

Baba

et al. 2022

International Journal of Surgery Case Reports

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“…Reviewing 250 patients with subcentimeter NIFTP from nine studies (Thompson 2016, Can et al 2017, Hahn et al 2017, Kwon et al 2017, Johnson & Sadow 2018, Mainthia et al 2018, Rosario 2018c, Shafique et al 2018, Xu et al 2018, without associated PTC, we found only two patients with micrometastases <2 mm in a single lymph node in the central compartment, none with distant metastases and no case of recurrence. In addition, reviewing 265 patients with NIFTP ≥4 cm (Thompson 2016, Golding et al 2017, Kwon et al 2017, Rosario 2017b, Xu et al 2017a, Chereau et al 2019, Kim et al 2018b, Mainthia et al 2018, Parente et al 2018, excluding cases with associated PTC, we did not identify any patients with lymph node metastases (LNM), only one with pulmonary metastases and no case of recurrence.…”

Section: Diagnosis Of Niftpmentioning

confidence: 89%

“…Despite the small number of reported cases, the diagnosis of NIFTP also applies to children and adolescents and the absence of metastases has been demonstrated in this age group (Chereau et al 2019, Rosario & Mourão 2018.…”

Section: Diagnosis Of Niftpmentioning

confidence: 98%

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): a review for clinicians

Rosário

Mourão

2019

Endocrine-Related Cancer

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Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an encapsulated or clearly delimited, noninvasive neoplasm with a follicular growth pattern and nuclear features of papillary thyroid carcinoma (PTC). It is considered a ‘pre-malignant’ lesion of the RAS-like group. Ultrasonography (US), cytology and molecular tests are useful to suspect thyroid nodules that correspond to NIFTP but there is wide overlap of the results with the encapsulated follicular variant of PTC (E-FVPTC). In these nodules that possibly or likely correspond to NIFTP, if surgery is indicated, lobectomy is favored over total thyroidectomy. The diagnosis of NIFTP is made after complete resection of the lesion by observing well-defined criteria. In the case of patients who received the diagnosis of FVPTC and whose pathology report does not show findings of malignancy (lymph node metastasis, extrathyroidal invasion, vascular/capsular invasion), if the tumor was encapsulated or well delimited, the slides can be revised by an experienced pathologist to determine whether the diagnostic criteria of NIFTP are met, but special attention must be paid to the adequate representativeness of the capsule and tumor. Since NIFTP is not ‘malignant’, tumor staging is not necessary and patients are not submitted to thyroid cancer protocols or guidelines. We believe that patients with NIFTP without associated malignancy and without nodules detected by US of the remnant lobe (if submitted to lobectomy) can be managed like those with follicular adenoma.

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“…(PTC) that can be treated as indolent, perhaps benign, tumours. It is diagnosed on histopathology using strict criteria first proposed by Nikiforov et al 7 NIFTPs are known to have a very low recurrence rate (near zero), 8 therefore its diagnosis may reduce the patient's psychological burden and decrease over-treatment. However, little is known in terms of the ROM per TBSRTC in a Singapore patient population and how the introduction of NIFTP may affect the ROM.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: Data from Singapore

Lee

Bundele

Tan

et al. 2021

Ann Acad Med Singap

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Introduction: The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the risk of malignancy (ROM) in fine-needle aspiration cytology (FNAC) per The Bethesda System for Reporting Thyroid Cytopathology has not been well reported in Singapore. Methods: We retrospectively identified 821 thyroid nodules with preoperative FNAC from 788 patients out of 1,279 consecutive thyroidectomies performed between January 2010 and August 2016 in a tertiary general hospital in Singapore. Possible cases of NIFTP were reviewed for reclassification and the impact of NIFTP on ROM was analysed. Results: The incidence of NIFTP was 1.2% (10 out of 821). If NIFTP is considered benign, ROM in Bethesda I through VI were 8.6%, 3.5%, 26.3%, 20.0%, 87.7%, 97.0% versus 8.6%, 4.2%, 28.1%, 26.7%, 89.2% and 100% if NIFTP is considered malignant. Eight patients with NIFTP had follow-up of 15 to 110 months. One had possible rib metastasis as evidenced by I131 uptake but remained free of structural or biochemical disease during a follow-up period of 110 months. None had lymph node metastasis at presentation, nor locoregional or distant recurrence. Conclusion: Classifying NIFTP as benign decreased ROM in Bethesda II through VI, but the benignity of NIFTP requires more prospective studies to ascertain. The impact of NIFTP on ROM in our institution also appears to be lower than that reported in the Western studies Keywords: Bethesda, cytology, NIFTP, risk of malignancy, TBSRTC, thyroid nodule

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NIFT-P: Are they indolent tumors? Results of a multi-institutional study

Cited by 16 publications

References 22 publications

What you see might not be what you get: Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

What you see might not be what you get: Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): a review for clinicians

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: Data from Singapore

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