Nigella sativa L. (Ranunculaceae)

Akbar, Shahid

doi:10.1007/978-3-030-16807-0_135

Cited by 2 publications

(1 citation statement)

References 153 publications

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“…sativa ( N. sativa ) have different types of pharmacologically active substances, such as thymol, dithymoquinone, thymoquinone, carvacrol, alpha-hedrin, nigellicine-N-oxide, and nigellidine, which help in strengthening of paraimmunity ( Ghaly et al., 2017 ; Saleh et al., 2018 ). The seeds of N. sativa have been used to treat coughs, dropsy, vomiting, diarrhoea, obesity, abdominal pain, stomachic, hepatic disorders, intermittent fevers, asthma, rheumatism, skin diseases, diuretic, joint pain, diaphoretic, dyspepsia, carminative, migraine, and chronic headache ( Hussain and Hussain, 2016 ; Srinivasan, 2018 ; Arif, 2019 ; Akbar, 2020 ). The N. sativa and its various extracts have antibacterial activity and also inhibit the production of aflatoxin ( Abdallah, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Response of lymphatic tissues to natural feed additives, curcumin (Curcuma longa) and black cumin seeds (Nigella sativa), in broilers against Pasteurella multocida

Raheem

Yin

et al. 2021

Poultry Science

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The antibiotic residues and pathogenic resistance against the drug are very common in poultry because of antibiotics used in their feed. It is necessary to use natural feed additives as effective alternatives instead of a synthetic antibiotic. This study aimed to investigate the immune response of Nigella sativa and Curcuma longa in broilers under biological stress against Pasteurella multocida . The total 100, one-day-old chicks were divided into 5 groups. Groups 1 and 2 served as control negative and control positive. Both control groups were receiving simple diet without any natural feed additives, but the infection was given in group 2 at day 28 with the dose of 5.14 × 10 7 CFU by IV. Groups 3A and 3B were offered 2% seed powder of Nigella sativ a, groups 4A and 4B were offered C. longa 1% in powdered form, and group 5A and 5B were offered both C. longa 1% and N. sativa 2% in the feed from day 1 and groups 3B, 4B, and 5B were challenged with P. multocida . The haemagglutination inhibition titter against Newcastle Disease virus (NDV), feed conversion ratio, mortality, gross, and histopathology were studied. The results of this study revealed that hemagglutination inhibition titers against NDV were highly significant ( P < 0.05) in treated groups, highest titers (3A, 6.8; 3B, 6.4; and 5A, 7.2) were obtained from treated Groups. The feed conversion ratio of N. sativa + C. longa treated groups (5A, 1.57, and 3A, 1.76) were higher than that of other nontreated groups. The gross and histopathological changes were much severe in control positive, but fewer changes were seen in treated groups. Therefore, we recommend that natural feed additives, black cumin (N. sativa) and turmeric ( C. longa ), act as an immune enhancer in broilers against P. multocida.

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Section: Introductionmentioning

confidence: 99%

Response of lymphatic tissues to natural feed additives, curcumin (Curcuma longa) and black cumin seeds (Nigella sativa), in broilers against Pasteurella multocida

Raheem

Yin

et al. 2021

Poultry Science

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Impact of Gestational Diabetes on the Thymus Gland of Rat’s Offspring and the Possible Ameliorating Effect of Thymoquinone: Biochemical, Histological, and Immunohistochemical Study

Mokhtar

Mokhemer

Mohammed

et al. 2023

Microscopy and Microanalysis

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Gestational diabetes mellitus (GDM) not only has short-term side effects on offspring but also has an increased risk of developing chronic diseases in adulthood. The thymus gland is a vital organ of immune system and thymoquinone (TQ) has an immunomodulatory effect. This study aimed to investigate the long-term adverse effects of GDM on offspring’s thymus gland and the ameliorating effect of TQ. Pregnant rats were divided into four groups: C-group, T-group, GD-group, and GD + T-group. Offspring of all groups were subdivided into two subgroups, one sacrificed on day 21 and the other on day 42. The thymus of the offspring in the GD-group at both time points revealed a significant decrease in thymic weight, superoxide dismutase (SOD), and reduced glutathione (GSH) levels with a significant increase in malondialdehyde (MDA), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α) levels. Moreover, there were microscopic degenerative changes, a significant decrease in C/M ratio, CD3, CD4, and CD8 immune expression, and a significant increase in activated caspase-3 immune expression. Interestingly, TQ administration revealed a significant increase in thymic weight, thymic SOD and GSH, C/M ratio, and CD3, CD4, and CD8 immune expression with a significant decrease in MDA, IL-8, TNF-α and activated caspase-3. For the first time, this study has shown that GDM causes long-term oxidative stress, apoptosis, and inflammation in offspring’s thymus and these changes could be attenuated by TQ.

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Nigella sativa L. (Ranunculaceae)

Cited by 2 publications

References 153 publications

Response of lymphatic tissues to natural feed additives, curcumin (Curcuma longa) and black cumin seeds (Nigella sativa), in broilers against Pasteurella multocida

Response of lymphatic tissues to natural feed additives, curcumin (Curcuma longa) and black cumin seeds (Nigella sativa), in broilers against Pasteurella multocida

Impact of Gestational Diabetes on the Thymus Gland of Rat’s Offspring and the Possible Ameliorating Effect of Thymoquinone: Biochemical, Histological, and Immunohistochemical Study

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