Nigella sativa OIL COULD INDUCE OSTEOGENIC DIFFERENTIATION OF DENTAL PULP MESENCHYMAL STEM CELLS: CLINICAL NUTRITION FOR DENTISTRY

Mendi, Ayşegül

doi:10.3153/jfhs18003

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…It was observed that combined N sativa oil /MSCs therapy provided more beneficial tissue repair comparable to MSCs alone [45] . Also, N sativa oil has an anabolic effect on MSCs to stimulate their differentiation [46] . So, it could help in the repair of the damaged duodenal mucosal tissue by stimulating the proliferation of the intestinal stem cells.…”

Section: Discussionmentioning

confidence: 99%

Effect of Fosamax on the duodenal mucosa in adult male albino rats and the possible protection by nigella sativa oil: a histological and immunohistochemical study

Kassab

2019

Egyptian Journal of Histology

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Background: Fosamax, an oral bisphosphonate, is the most commonly prescribed drug for the treatment of various bones diseases. However, Fosamax therapy is associated with gastrointestinal toxicity that influences the treatment compliance. Nigella sativa (N sativa) is an annual herbaceous plant and have been safely used as a natural remedy in Egypt. It has a wide range of pharmacological activities and a proposed role in combating many gastrointestinal disorders. Aim: This work aimed to study the effect of Fosamax on the histological structure of the duodenal mucosa of albino rats and to evaluate the possible protective role of nigella sativa oil. Materials and methods: Forty adult male albino rats were divided into four equal groups: the control group, the N sativa oil-treated group (2.5 ml/kg), the Fosamax-treated group (0.05mg/kg), and both Fosamax and N sativa oil-treated group. Treatments were given orally once weekly for 13 weeks. Specimens from the duodenum were processed for light microscopy. Immunohistochemical study was carried out using antibodies against nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2), B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and Ki67 protein. Results: Specimens from Fosamax-treated rats showed a statistically significant decrease in the duodenal mucosal thickness. The lining epithelium showed nuclear alteration and vacuolated cytoplasm and there was mononuclear cellular infiltration. The immunohistochemical study of Fosamax-treated group showed a significant increase in NF-kB, COX-2 and Bax immunoreaction and a significant decrease in Bcl-2 and Ki67 expression. In contrast, minimal changes were observed in rats treated concomitantly with both Fosamax and N sativa oil with non-significant changes in the immunoreactions compared with the control group. Conclusion: Fosamax induced structural changes in the duodenal mucosa of adult albino rats, which could be ameliorated by concomitant treatment with nigella sativa oil.

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Section: Discussionmentioning

confidence: 99%

Effect of Fosamax on the duodenal mucosa in adult male albino rats and the possible protection by nigella sativa oil: a histological and immunohistochemical study

Kassab

2019

Egyptian Journal of Histology

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“…Nanoemulgels consist of a water-in-oil or oil-in-water emulsion embedded in a gel base [ 5 ]. A role for N. sativa as a dental therapeutic agent in the treatment of periodontal diseases has been established owing to its pharmacological actions, including antibacterial, antifungal, antiplaque, wound-healing, bone-healing, anti-inflammatory, antioxidant, and analgesic activities [ 6 , 7 , 8 , 9 , 10 ]. Periodontal diseases are the top oral health burden in both developing and developed nations; they affect around 20–50% of the population and are most common reason for tooth loss [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

et al. 2022

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The present study aimed to develop a local dental nanoemulgel formulation of Nigella sativa oil (NSO) for the treatment of periodontal diseases. NSO purchased from a local market was characterized using a GC–MS technique. A nanoemulsion containing NSO was prepared and incorporated into a methylcellulose gel base to develop the nanoemulgel formulation. The developed formulation was optimized using a Box–Behnken statistical design (quadratic model) with 17 runs. The effects of independent factors, such as water, oil, and polymer concentrations, were studied on two dependent responses, pH and viscosity. The optimized formulation was further evaluated for droplet size, drug release, stability, and antimicrobial efficacy. The developed formulation had a pH of 7.37, viscosity of 2343 cp, and droplet size of 342 ± 36.6 nm. Sustained release of the drug from the gel for up to 8 h was observed, which followed Higuchi release kinetics with non-Fickian diffusion. The developed nanoemulgel formulation showed improved antimicrobial activity compared to the plain NSO. Given the increasing emergence of periodontal diseases and antimicrobial resistance, an effective formulation based on a natural antibacterial agent is warranted as a dental therapeutic agent.

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“…Researchers studied the impact of thymoquinone on cell proliferation and noticed that it could stimulate the formation of fibroblasts & collagen production throughout wound repair in rabbits [51]. Others found that thymoquinone could stimulate dental pulp mesenchymal cells' osteogenic differentiation [52,53].…”

Section: Discussionmentioning

confidence: 99%

Biological Potential of the Main Component, Thymoquinone, of Nigella sativa in Pulp Therapy-In Vitro Study

Alamoudi,

Alamoudi

2022

Prime Archives in Biosciences

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Nigella sativa OIL COULD INDUCE OSTEOGENIC DIFFERENTIATION OF DENTAL PULP MESENCHYMAL STEM CELLS: CLINICAL NUTRITION FOR DENTISTRY

Cited by 8 publications

References 12 publications

Effect of Fosamax on the duodenal mucosa in adult male albino rats and the possible protection by nigella sativa oil: a histological and immunohistochemical study

Effect of Fosamax on the duodenal mucosa in adult male albino rats and the possible protection by nigella sativa oil: a histological and immunohistochemical study

Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

Biological Potential of the Main Component, Thymoquinone, of Nigella sativa in Pulp Therapy-In Vitro Study

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