Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats

Beheshti, Farimah; Norouzi, Fatemeh; Abareshi, Azam; Khazaei, Majid; Alikhani, Vida; Moussavi, Sussan; Biglari, Ghazale; Soukhtanloo, Mohammad; Hosseini, Mahmoud

doi:10.4103/1319-2442.235184

Cited by 26 publications

(8 citation statements)

References 4 publications

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“…Previous studies conducted on Nigella sativa (NS) oil and its main bioactive constituent TQ showed that they have both antioxidant and renoprotective properties in STZ-induced diabetes in the animal models and in ischemia-reperfusion-induced renal disorders [ 10 , 11 ]. In addition, NS and TQ were recently reported to have the potential to prevent renal tissue damage and fibrosis in lipopolysaccharide- (LPS-) treated rats through its antioxidant and anti-inflammatory effects [ 12 , 13 ]. It was reported that the hydroalcoholic extract of NS could protect the renal tissue against oxidative stress associated with neonatal and juvenile hypothyroidism in rats [ 14 ]…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats

Ayuob

Balgoon

El-Mansy

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. The association between hypothyroidism and renal diseases has been described in many studies. Nigella Sativa was among the recently reported natural product that has the potential to prevent renal tissue damage and fibrosis. The aim of this study was to evaluate the possible protective effect of thymoquinone on the structure of the renal cortex of hypothyroid rats and explore the mechanism behind it. Methods. An experimental model of hypothyroidism was induced in adult male Wistar rats by administration of propylthiouracil (6 mg/kg/body weight). One hypothyroid group was treated with thymoquinone at the dose of 50 mg/kg/body weight and compared to the untreated group. Thyroid function and oxidant/antioxidant status were assessed in the serum. Catalase gene expression was assessed using the real-time polymerase chain reaction. The kidney was assessed both histologically and immunohistochemically. Results. Administration of propylthiouracil resulted in a significant decrease in the serum levels of nitric oxide, reduced glutathione, and superoxide dismutase activity while the level of malondialdehyde significantly (p<0.001) increased. Administration of thymoquinone alleviated this effect on the thyroid hormones and significantly increased the serum levels of antioxidants. Thymoquinone significantly (p<0.001) upregulated catalase transcription by about 24-fold and could block the hypothyroidism-induced glomerular and tubular injury. Conclusion. Thymoquinone may have a potential protective effect against hypothyroidism-induced renal injury acting through the attenuation of the oxidative stress and upregulation of renal catalase gene expression.

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Section: Introductionmentioning

confidence: 99%

Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats

Ayuob

Balgoon

El-Mansy

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…47 • Exerts therapeutic and anti-oxidant effects against lipopolysaccharides-induced inflammation in diabetic patients. 48…”

Section: Hepatoprotectivementioning

confidence: 99%

“… 47 Exerts therapeutic and anti-oxidant effects against lipopolysaccharides-induced inflammation in diabetic patients. 48 Antifibrotic effect Attenuates hepatic fibrosis. 49 Nutritional supplement Nigella sativa improves malnutrition associated with metabolic diseases, eg, Refsum’s disease.…”

Section: Prophetic Medicine Remedies As Promising Adjuvants For Treat...mentioning

confidence: 99%

Al-Hijamah (Prophetic Wet Cupping Therapy) is a Novel Adjuvant Treatment for Viral Hepatitis That Excretes Viral Particles and Excess Ferritin Percutaneously, Synergizes Pharmacotherapy, Enhances Antiviral Immunity and Helps Better HCC Prevention and Treatment: A Novel Evidence-Based Combination with Prophetic Medicine Remedies

El Sayed

2023

JHC

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Viral hepatitis progresses to liver cirrhosis and HCC. Several challenges are facing Sovaldi treatment to viral C hepatitis, eg, viral resistance, difficulty to treat all genotypes, and inability to access treatments in low-income countries. Also, current treatments to Hepatitis B are still challenging. Ideal treatments to viral hepatitis should decrease the viral load, enhance antiviral immunity and repair the viruses-induced tissue damage. That is still beyond reach. High serum ferritin in viral hepatitis correlates with chronicity, increased necroinflammation, hepatotoxicity, progression to cirrhosis, progression to HCC, unresponsiveness to treatments and viremia. Previously, Alhijamah (wet cupping therapy of prophetic medicine) significantly cleared thalassemic children of causative pathological substances (CPS), eg, excess ferritin, free radicals and serum lipids. Moreover, Al-hijamah significantly increased the antioxidant power and potentiated the natural antiviral immunity, eg, increasing CD4 count, CD8 count and CD4/CD8 ratio. Prophet Muhammad peace be upon him said: "If there is a benenvolence (benefit) in any of your medicines, benefit will be in shrtat mihjam (Al-hijamah), honey drink, and a stinge of fire compatible with disease and I do not like to cauterize". Likewise, the author suggests Al-hijamah as a novel promising adjuvant treatment for viral hepatitis (B and C) for percutaneous excretion of CPS as hepatitis viral particles, excess ferritin, inflammatory mediators, free radicals, and antigen-antibody complexes. Published reports proved that Al-hijamah exerted tissue-protective effects, and cleared blood through the fenestrated skin capillaries in a pressure-dependent and size-dependent manner (a kidney-like manner). That collectively may decrease the viral load for better HCC prevention and supports the evidence-based Taibah theory (Taibah mechanism). Same therapeutic benefits apply to other viral illnesses as AIDS. Even after HCC development, Al-hijamah is quite mandatory for excretion and clearance of CPS that favor malignancy, eg, lactate (Warburg effect), growth factors, metalloproteinases, and others. Al-hijamah-induced immune potentiation benefits HCC patients. Combining Al-hijamah with other natural antioxidant remedies of prophetic medicine, eg, nigella sativa, costus, natural honey, Zamzam water and others will maximize the therapeutic benefits. In conclusion, Al-hijamah and other prophetic medicine remedies are recommended adjuvants to current pharmacological treatments to viral hepatitis and HCC.

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“…There have been reports of renal impairment occurring alongside oxidative tissue damage when there is inflammation 37 . Chronic kidney disease's pathophysiological foundation includes OxS, apoptosis, and inflammation.…”

Section: Renal Tissue Antioxidantmentioning

confidence: 99%

Iron-Overload Conditions: Manifestations to the Kidney Organs – A Review

Heriatmo,

Estuningtyas,

Soetikno

2023

Borneo J Pharm

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Excess iron is a risk factor for organ dysfunction and damage resulting in various organ diseases such as liver, heart, and kidney, diabetes mellitus, and neurodegenerative diseases. Iron overload in some individuals is caused by various factors, including genetic predisposition such as genetic hemochromatosis, repeated transfusion of red blood cells, and parenteral iron administration in conditions of transfusion-dependent anemia. A disturbance in the globin gene in diseases such as β-thalassemia major causes an imbalance of the globin chain, resulting in chronic anemia in the sufferer. It has been reported that the human body does not have a mechanism for eliminating excess iron levels. Routine transfusion has become a solution to overcome chronic anemia so that patients can maintain hemoglobin levels, and the result of this transfusion repetition is the accumulation of iron in various organs, such as the heart, liver, endocrine glands, pancreas, lungs, and kidneys. Excess iron can be toxic to the body due to the formation of harmful free radicals that can damage cells and tissues. An increase in excessive ROS can result in the saturation of the antioxidant system. The presence of free radicals can lead to damage and the occurrence of filtration dysfunction in the glomerulus.

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Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats

Cited by 26 publications

References 4 publications

Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats

Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats

Iron-Overload Conditions: Manifestations to the Kidney Organs – A Review

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