Nigerian mistletoe (Loranthus micranthus Linn) aqueous leaves extract modulates some cardiovascular disease risk factors in monosodium glutamate induced metabolic dysfunction

Ajani, Emmanuel Oladipo; Ogunlabi, Olugbenga; Adegbesan, Bukunola Oluyemisi; Adeosun, Opeyemi A.; Akinwande, O.

doi:10.5897/ajb2014.14029

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…With such an enormous appetite for this additive in the food industry, the health concerns are also substantial given that MSG administration increases the number of pachytene stage cells in primary spermatocytes [ 12 , 13 ] and induces OS [ 14 , 15 ] and free radical generation [ 16 , 17 ]. In addition, obesity [ 18 , 19 , 20 , 21 ], disorders of the central nervous system [ 10 , 22 , 23 ], hepatic damage [ 24 , 25 , 26 ], reproductive malfunctions [ 12 , 27 , 28 , 29 ], cardiovascular diseases [ 30 , 31 ], and hypertension [ 32 , 33 , 34 ] are considered to be some of the major side effects of MSG.…”

Section: Introductionmentioning

confidence: 99%

Monosodium Glutamate Perturbs Human Trophoblast Invasion and Differentiation through a Reactive Oxygen Species-Mediated Pathway: An In-Vitro Assessment

et al. 2023

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The overproduction of reactive oxygen species (ROS) has been associated with various human diseases. ROS exert a multitude of biological effects with both physiological and pathological consequences. Monosodium glutamate (MSG), a sodium salt of the natural amino acid glutamate, is a flavor-enhancing food additive, which is widely used in Asian cuisine and is an ingredient that brings out the “umami” meat flavor. MSG consumption in rats is associated with ROS generation. Owing to its consumption as part of the fast-food culture and concerns about its possible effects on pregnancy, we aimed to study the impact of MSG on placental trophoblast cells. MSG exposure influenced trophoblast invasion and differentiation, two of the most critical functions during placentation through enhanced production of ROS. Similar findings were also observed on MSG-treated placental explants, as confirmed by elevated Nrf2 levels. Ultrastructural studies revealed signs of subcellular injury by MSG exposure. Mechanistically, MSG-induced oxidative stress with endoplasmic reticulum stress pathways involving Xbp1s and IRE1α was observed. The effect of MSG through an increased ROS production indicates that its long-term exposure might have adverse health effect by compromising key trophoblast functions.

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Section: Introductionmentioning

confidence: 99%

Monosodium Glutamate Perturbs Human Trophoblast Invasion and Differentiation through a Reactive Oxygen Species-Mediated Pathway: An In-Vitro Assessment

et al. 2023

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Pre-Treatment With Phyllanthus Amarus Stalls Dyslipidemia and Uterine Toxicity in Monosodium Glutamate Administered Rats

Ogunlabi

Adegbesan

Adebisi

et al. 2020

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Studies have implicated intake of monosodium glutamate (MSG) in fibroid development, but reports on the correlation between dyslipidemia and fibroid induction with an intake of MSG are inconsistent. This study investigates the risk of dyslipidemia in MSG intake and the therapeutic effect of administration of Phyllanthus amarus. Forty adult female Wistar rats randomize to 5 groups of 8 rats each were used. MSG was administered continuously to groups 2-5 at 200 mg/Kg body weight for 28 days. After 28 days, blood was withdrawn from rats in groups1, 2 and 3after anaesthetizing with diethyl ether. They were then sacrificed and the uterus, kidney and liver excised. MSG administrations were later discontinued in the remaining groups of rats, and P. amarus leaves extract was administered daily to group 4. Treatments were later continued for the next 28 days after which the rats were sacrificed. Total cholesterol (TC), Low-density lipoprotein (LDL-c), High-density lipoprotein (HDL-c), triglyceride, artherogenic (AI) and coronary risk index (CRI), glucose and total protein were then determined in the serum. The organs were also weighed, and the uterus was used for histopathology studies. Results indicate that serum cholesterol, LDL-c, triglycerides, API, CRI and glucose were raised with MSG administration whereas; HDL-c was reduced. Co-administration of P. amarus with MSG prevented these alterations. Withdrawal of MSG without treatment and administration of P. amarus after MSG administration also reduced the cholesterol, triglyceride, LDL, AI and CRI. Although the final body weights and uterine weight ratio were increased with MSG administration and co-administration of P. amarus with MSG prevented these alterations, no observable difference was observed in the histology of the uterine tissues. The study suggests that MSG administration is positively correlated with dyslipidemia and uterine toxicity. Results also show that co-administration of P. amarus with MSG may offer protection against these metabolic changes

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Nigerian mistletoe (Loranthus micranthus Linn) aqueous leaves extract modulates some cardiovascular disease risk factors in monosodium glutamate induced metabolic dysfunction

Abstract: The safety globally. Th disorder as rats), 2 (21 (200 mg/Kg were then s labeled 4 a treated wit administrat analysis. A cholesterol cholesterol micranthus significant L. micranth

Cited by 2 publications

References 34 publications

Monosodium Glutamate Perturbs Human Trophoblast Invasion and Differentiation through a Reactive Oxygen Species-Mediated Pathway: An In-Vitro Assessment

Monosodium Glutamate Perturbs Human Trophoblast Invasion and Differentiation through a Reactive Oxygen Species-Mediated Pathway: An In-Vitro Assessment

Pre-Treatment With Phyllanthus Amarus Stalls Dyslipidemia and Uterine Toxicity in Monosodium Glutamate Administered Rats

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