Night shift work and incidence of diabetes in the Danish Nurse Cohort

Hansen, Anne B; Stayner, Leslie T.; Hansen, Johnni; Andersen, Zorana Jovanovic

doi:10.1136/oemed-2015-103342

Cited by 121 publications

(102 citation statements)

References 36 publications

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“…Another study showed that the evening chronotype was risk of diabetes and metabolic syndromes [16]. In fact, it is well known that night shift work is a risk of incident diabetes [17,18]. Thus, dinner timing is an important issue in the clinical setting.…”

mentioning

confidence: 99%

Late-night-dinner is associated with poor glycemic control in people with type 2 diabetes: The KAMOGAWA-DM cohort study

et al. 2018

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Abstract. Skipping breakfast or irregular breakfast is associated with poor glycemic control. However, a relationship between the timing of dinner and glycemic control in people with type 2 diabetes remains indefinite. Therefore, we investigated the relationship between late-night-dinner and glycemic control in people with type 2 diabetes. We performed questionnaire survey for lifestyle factors in this cross-sectional study. We defined having dinner later than eight pm as late-night-dinner. We examined the differences in clinical and metabolic parameters between those who have late-night-dinner and those who do not have. We also examined the relationship between late-night-dinner and HbA1c, using multiple regression analysis. Ninetyfive people (23.2%) had a late-night-dinner, among 409 people with type 2 diabetes. Metabolic parameters (mean (SD) or median (interquartile range)) of people with late-night-dinner were worse than those of without, including body mass index (BMI) (24.4 (4.0) vs. 23.2 (3.4) kg/m 2 , p = 0.006), triglycerides (1.5 (1.1-2.1) vs. 1.2 (0.8-1.7) mmol/L, p < 0.001), HDLcholesterol (1.4 (0.4) vs. 1.6 (0.4) mmol/L, p = 0.004) and hemoglobin A1c (58.1 (13.3) vs. 55.2 (10.2) mmol/mol, (7.5 (1.2) vs. 7.2 (0.9) %), p = 0.023)). Late-night-dinner (standardized regression coefficient = 0.13, p = 0.028) was associated with hemoglobin A1c after adjusting for age, BMI, sex, duration of diabetes, smoking, exercise, alcohol, snacking after dinner, nighttime sleep duration, time from dinner to bedtime, skipping breakfast, and medication for diabetes. Late-night-dinner is independently associated with poor glycemic control in people with type 2 diabetes.

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confidence: 99%

Late-night-dinner is associated with poor glycemic control in people with type 2 diabetes: The KAMOGAWA-DM cohort study

et al. 2018

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“…Observational studies suggest an association between shift work and various health problems, including circadian dysrhythmia, fatigue and insufficient recovery,1 2 breast cancer,3 cardiovascular disorders4 and type-II diabetes 5. Survey studies on shift work and health are sensitive for exposure misclassification 2 6.…”

Section: Introductionmentioning

confidence: 99%

Validity of self-reported exposure to shift work

et al. 2016

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“…Shift work has been associated with increased prevalence for obesity, diabetes, systemic inflammation, and other metabolic comorbidities. [78][79][80][81][82][83][84][85] Human participants exposed to a forced desynchrony protocol display hyperglycemia, insulin resistance, poor glucose tolerance, increased arterial pressure, and reversed cortisol rhythms when they are ~12 hours out of phase with the environmental light-dark cycle. 86 The 12-hour phase shifts also increase blood pressure, C-reactive protein, and inflammatory mediators and decrease vagal tone, …”

Section: Circadian Desynchronymentioning

confidence: 99%

Consequences of circadian dysregulation on metabolism

Cissé¹,

Nelson²

2016

CPT

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Most organisms display endogenously produced rhythms in physiology and behavior of ~24 hours in duration. These rhythms, termed circadian rhythms, are entrained to precisely 24 hours by the daily extrinsic light-dark cycle. Circadian rhythms are driven by a transcriptional-translational feedback loop that is hierarchically expressed throughout the brain and body; the suprachiasmatic nucleus of the hypothalamus is the master circadian oscillator at the top of the hierarchy. Precise timing of the circadian clocks is critical for many homeostatic processes, including energy regulation and metabolism. Many genes involved in metabolism display rhythmic oscillations. Because circadian rhythms are most potently synchronized with the external environment by light, exposure to light at night potentially disrupts circadian regulation. Other potential disruptors of circadian organization include night shift work, social jet lag, restricted sleep, and misaligned feeding. Each of these environmental conditions has been associated with metabolic changes and obesity. The goal of this review is to highlight how disruption of circadian organization, primarily due to night shift work and exposure to light at night, has downstream effects on metabolic function.

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Night shift work and incidence of diabetes in the Danish Nurse Cohort

Abstract: Danish nurses working night and evening shifts have increased risk for diabetes, with the highest risk associated with current night shift work.

Cited by 121 publications

References 36 publications

Late-night-dinner is associated with poor glycemic control in people with type 2 diabetes: The KAMOGAWA-DM cohort study

Late-night-dinner is associated with poor glycemic control in people with type 2 diabetes: The KAMOGAWA-DM cohort study

Validity of self-reported exposure to shift work

Consequences of circadian dysregulation on metabolism

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