Nightmares Associated With Vilazodone in a Patient With Major Depressive Disorder

A, De Sousa

doi:10.1097/jcp.0000000000000574

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Vilazodone is a potent selective serotonin reuptake inhibitor and serotonin 1A receptor partial agonist. The author states, “The neurobiological basis for the nightmares associated with vilazodone is unknown and whether neurobiological changes of depression play a role is an area that is nascent and needs further research.” 2 The author hypothesized that the action of vilazodone on 5-hydroxytryptophan-2 receptors may contribute to this phenomenon such as that that has occurred in selective serotonin reuptake inhibitors.…”

Section: Vilazodone-induced Nightmaresmentioning

confidence: 99%

ISMP Adverse Drug Reactions: Influenza Vaccine–Induced Stevens-Johnson Syndrome; Vilazodone-Induced Nightmares; Dabigatran-Induced Pustular Eruptions; Neurotoxic and Cardiotoxic Symptoms After Cannabis Concentrate Exposure; Rosuvastatin-Induced Skin Eruption

Mancano

2017

Hosp Pharm

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The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested. This feature is provided by the Institute for Safe Medication Practices (ISMP) in cooperation with the FDA's MedWatch program and Temple University School of Pharmacy. ISMP is an FDA MedWatch partner.

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Section: Vilazodone-induced Nightmaresmentioning

confidence: 99%

ISMP Adverse Drug Reactions: Influenza Vaccine–Induced Stevens-Johnson Syndrome; Vilazodone-Induced Nightmares; Dabigatran-Induced Pustular Eruptions; Neurotoxic and Cardiotoxic Symptoms After Cannabis Concentrate Exposure; Rosuvastatin-Induced Skin Eruption

Mancano

2017

Hosp Pharm

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Vilazodone

2016

Reactions Weekly

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Relative frequency of drug-induced sleep disorders for 32 antidepressants in a large set of Internet user reviews

Natter

Yokoyama

Michel

2021

Sleep

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Study Objectives It is known that antidepressant drugs can induce sleep disorders in patients, but little data exist about high or low-risk molecules. The aim was to study the frequency of antidepressant drugs-induced sleep disorders (DISD) by molecule. Methods 77,391 patient comments for 32 antidepressant drugs were collected from drug review websites and screened for DISD. Association between drugs and nightmare disorder, restless legs syndrome, sleep paralysis, sleep terrors, sleep-related hallucinations or sleep walking was expressed as relative proportion [proportional reporting ratio (PRR)]. A detailed analysis of the dreams content was also carried out. Results Amitriptyline, doxepin, fluvoxamine, mirtazapine, nortriptyline, trazodone, venlafaxine and vilazodone were associated with a greater frequency of DISD compared to other antidepressants. Vilazodone heavily increased the probability of developing 5 of the 6 studied DISD (PRR 3.3 to 19.3) and mirtazapine increased the probability for developing 4 DISD (PRR 2.4 to 6.4). Bupropion and citalopram were associated with lower probabilities for 5 DISD (PRR 0.2 to 0.7). Sentiment analysis showed that patients described disturbing dreams for vilazodone or mirtazapine and strange but less negative dreams for bupropion, citalopram or duloxetine. Conclusions Relative frequencies of sleep disorders were obtained for a vast panel of antidepressant drugs through an original analysis of user’s drug reviews on drug rating websites. Our results could guide clinicians in appropriate choice of antidepressant drug for high DISD-risk patients in need of such treatment. These results may however be cautiously taken, considering the uncertain reliability and generalisability of web-based data.

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Nightmares Associated With Vilazodone in a Patient With Major Depressive Disorder

Cited by 3 publications

References 9 publications

ISMP Adverse Drug Reactions: Influenza Vaccine–Induced Stevens-Johnson Syndrome; Vilazodone-Induced Nightmares; Dabigatran-Induced Pustular Eruptions; Neurotoxic and Cardiotoxic Symptoms After Cannabis Concentrate Exposure; Rosuvastatin-Induced Skin Eruption

ISMP Adverse Drug Reactions: Influenza Vaccine–Induced Stevens-Johnson Syndrome; Vilazodone-Induced Nightmares; Dabigatran-Induced Pustular Eruptions; Neurotoxic and Cardiotoxic Symptoms After Cannabis Concentrate Exposure; Rosuvastatin-Induced Skin Eruption

Vilazodone

Relative frequency of drug-induced sleep disorders for 32 antidepressants in a large set of Internet user reviews

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