Nighttime sleep duration, restlessness and risk of multimorbidity - A longitudinal study among middle-aged and older adults in China

Zou, Chenfeng; Sun, Haichun; Lu, Ciyong; Chen, Wei‐Qing; Guo, Vivian Yawei

doi:10.1016/j.archger.2021.104580

Cited by 18 publications

(9 citation statements)

References 45 publications

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“…A meta-analysis also revealed that short sleep duration was associated with numerous chronic diseases [ 25 ]. Consistent findings concerning multimorbidity were observed in both cross-sectional [ 26 ] and longitudinal studies [ 18 ]. However, there were some markedly different results in other previous studies that indicated that long sleep duration was associated with multimorbidity [ 27 , 28 ].…”

Section: Discussionsupporting

confidence: 73%

“…Previous authors had analysed a unidirectional association between sleep quality and multimorbidity, and a majority of their studies were congruent with our study. For example, a cross-sectional study on 3250 individuals aged 60 years and older in Shanxi Province of China showed that poor sleep quality was associated with the prevalence of multimorbidity (OR = 2.445; 95% CI, 2.043–2.927) [ 21 ], and a recent longitudinal study also indicated that poor sleep quality correlated with an increased risk of multimorbidity (RR: 1.750; 95% CI, 1.476–2.076) [ 18 ]. Regarding sleep duration and multimorbidity, previous studies have shown that short sleep duration increased the risk of cardiovascular diseases [ 22 ], hypertension [ 23 ], and asthma [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Sleep quality and duration were determined by the comments/question: “My sleep was restless in the last week.” and “During the past month, how many hours of actual sleep did you get at night?” The response options regarding self-reported sleep quality included rarely or none of the time (< 1 day), some of the time (1–2 days), occasionally or a moderate amount of the time (3–4 days), and most or all of the time (5–7 days). We classified sleep quality into “good” (rarely or none of the time, < 1 day per week) and “poor” (≥ 1 day per week) [ 18 ]. Based on previous studies [ 19 , 20 ], night-time sleep duration was divided into short (< 6 h), medium (6–9 h), and long (> 9 h).…”

Section: Methodsmentioning

confidence: 99%

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Bidirectional associations between sleep quality/duration and multimorbidity in middle-aged and older people Chinese adults: a longitudinal study

Wang,

Zhang

2024

BMC Public Health

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Background Multimorbidity and sleep disorder possess high incidence rates in the middle-aged and older people populations, posing a significant threat to quality of life and physical and mental health. However, investigators have previously only analysed the unidirectional association between sleep status and multimorbidity. We aimed to investigate bidirectional associations between sleep quality or duration and multimorbidity in middle-aged and older Chinese adults from a longitudinal perspective. Method We enrolled a total of 9823 participants 45 years and older from the China Health and Retirement Longitudinal Study from 2015 to 2018 in our study. Multimorbidity was defined as two or more coexisting chronic diseases in the same individual based on 14 self-reported disease questions. Sleep quality was classified as “good” (restless < 1 day per week) and “poor” (restless ≥ 1 days per week); and sleep duration was divided into short (< 6 h), medium (6–9 h), and long (> 9 h). The bidirectional association between multimorbidity and sleep condition was examined using multivariate logistic regression models with adjustments for covariates. Results Individuals with poor sleep quality showed a significantly higher prevalence of multimorbidity in the future. The adjusted OR (95% CI) values of individuals with poor sleep quality with respect to developing two diseases, three diseases, and ≥ 4 diseases were 1.39 (1.19, 1.63), 1.56 (1.23, 2.03), and 2.36 (1.68, 3.33), respectively. In addition, individuals with multimorbidity exhibited a significantly higher risk of poor sleep quality in the future. Short sleep duration led to multimorbidity in the future (OR = 1.49; 95 CI%, 1.37–1.63), while multimorbidity contributed to short sleep duration (< 6 h) in the future (OR = 1.39; 95% CI, 1.27–1.51) after full adjustment. Conclusions There was a bidirectional association between sleep quality or short sleep duration and multimorbidity in middle-aged and older Chinese adults. We recommend that greater attention be given to clinical management among adults with sleep disorders or physical multimorbidities.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Bidirectional associations between sleep quality/duration and multimorbidity in middle-aged and older people Chinese adults: a longitudinal study

Wang,

Zhang

2024

BMC Public Health

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“…[ [37][38][39] Only a few papers provided a definition for the SWCD that was reported in the paper or how it was assessed. Therefore, each criterion that was found in the literature was first considered individually.…”

Section: Restlessnessmentioning

confidence: 99%

Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis

et al. 2022

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Tick-borne encephalitis (TBE) is an infectious disease affecting the central nervous system. Recently, the occurrence of TBEV infections has steadily increased, reaching all-time high incidence rates in European countries. Up to 50% of patients with TBE present neurological sequelae, among them sleep–wake and circadian disorders (SWCD), which are poorly characterized. The aim of this review is to investigate the prevalence, clinical characteristics, and prognosis of SWCD after TBE. The literature review was performed in accordance with PRISMA guidelines. The quality of the paper was assessed using a standardized quality assessment. The analysis of SWCD was categorized into four different time intervals and two age groups. The literature search identified 15 studies, five including children and 10 including adults. In children, fatigue was most frequently observed with a prevalence of 73.9%, followed by somnolence/sleepiness, restlessness, and sleep-wake inversion. In adults, tiredness/fatigue was the most reported sequela with a prevalence of 27.4%, followed by extensive daytime sleepiness/somnolence, and insomnia (3.3%). Two studies showed impaired social outcomes in patients after TBE infections. SWCD after TBE in children and adults is a newly recognized sequela. Additional clinical and experimental research is needed to gain more precise insight into the clinical burden of SWCD after TBE and the underlying mechanisms.

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“…Optimal sleep duration plays an essential role in maintaining human health and wellbeing ( 10 ). Previous studies have identified extreme sleep duration as a critical lifestyle risk factor for a series of chronic diseases ( 11 ), such as diabetes mellitus ( 12 ) and chronic kidney disease ( 13 , 14 ). Recently, several studies have suggested that sleep duration may be a potentially modifiable risk factor for hyperuricemia ( 15 – 18 ).…”

Section: Introductionmentioning

confidence: 99%

Linear and non-linear Mendelian randomization analyses of sex-specific associations between sleep duration and hyperuricemia

Zou

Wang

et al. 2022

Front. Nutr.

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BackgroundObservational studies have suggested a potential non-linear association between sleep duration and hyperuricemia. However, the causal nature and sex-specific differences are poorly understood. We aimed to determine the shape of sex-specific causal associations between sleep duration and hyperuricemia in the UK Biobank.MethodsLogistic regression was used to investigate the observational association between self-reported sleep duration and hyperuricemia among 387,980 white British participants (mean age: 56.9 years and 46.0% males). Linear and non-linear Mendelian Randomization (MR) analyses were performed to assess the causal association between continuous sleep duration and hyperuricemia. The causal effects of genetically predicted short (<7 h) and long (>8 h) sleep durations on hyperuricemia were further estimated, respectively.ResultsTraditional observational analysis suggested U- and J-shaped associations between sleep duration and hyperuricemia in females and males, respectively. Linear MR did not support the causal effect of sleep duration on hyperuricemia. Non-linear MR demonstrated an approximately U-shaped causal association between continuous sleep duration and hyperuricemia in overall participants and females, but not in males. Genetically predicted short sleep duration was significantly associated with hyperuricemia in females (OR [95% CI]: 1.21 [1.08–1.36]; P = 0.001), but not in males (1.08 [0.98–1.18]; P = 0.137). By contrast, genetically predicted long sleep duration was not significantly associated with the risk of hyperuricemia in either females or males.ConclusionGenetically predicted short sleep duration is a potential causal risk factor for hyperuricemia for females but has little effect on males. Long sleep duration does not appear to be causally associated with hyperuricemia.

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Nighttime sleep duration, restlessness and risk of multimorbidity - A longitudinal study among middle-aged and older adults in China

Cited by 18 publications

References 45 publications

Bidirectional associations between sleep quality/duration and multimorbidity in middle-aged and older people Chinese adults: a longitudinal study

Bidirectional associations between sleep quality/duration and multimorbidity in middle-aged and older people Chinese adults: a longitudinal study

Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis

Linear and non-linear Mendelian randomization analyses of sex-specific associations between sleep duration and hyperuricemia

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