Nigral iron deposition occurs across motor phenotypes of Parkinson’s disease

Abstract

These findings suggest that nigral iron deposition, correlating with decreased serum ceruloplasmin levels, is a risk factor in Parkinson's disease across multiple motor phenotypic expressions.

Ndfip1 attenuated 6-OHDA–induced iron accumulation via regulating the degradation of DMT1

“…Elevated iron levels have been found in the SN of PD patient and animal models (Jiang et al, 2010;Salazar et al, 2008;Youdim et al, 2004;Zecca et al, 2004). Extensive studies have proved that iron played a key role in the etiology of PD (Jin et al, 2012;Rossi et al, 2014;Zhang et al, 2014). However, the reasons underlying iron accumulation in PD are not very clear until now.…”

Serum microRNA-133b is associated with low ceruloplasmin levels in Parkinson's disease

“…These subgroups were assigned based on the ratio of each patient's mean UPDRS III Tremor score (sum of items 20 and 21 divided by 4) to his/her mean UPDRS akinetic/ rigid scores (sum of items 22e27 and 31 divided by 15), as previously reported [11]. Patients with the following conditions were excluded: signs of upper and/or lower motor neuron dysfunction, orthostatic hypotension within three years of PD onset, cognitive impairment assessed by the MMSE, and hepatic and/or renal dysfunction.…”

Single-nucleotide polymorphisms and haplotypes of non-coding area in the CP gene are correlated with Parkinson’s disease

“…CP oxidizes ferrous iron into the ferric form and thus keeps the intracellular level of dangerous ferrous iron to a minimum [3,4] and 21 divided by 4) to his/her average UPDRS akinetic/ rigid score (sum of items 22-27 and 31 divided by 15), as previously reported [16] . Patients This study was approved by the Committee on Medical Ethics of Zhongshan Hospital, Fudan University, and all participants gave informed consent.…”