Nigral neurotensin receptor regulation of nigral glutamate and nigroventral thalamic GABA transmission: a dual-probe microdialysis study in intact conscious rat brain

Ferraro, Luca; Tomasini, Maria Cristina; Fernández, Miriam; Bebe, Berta Wonjie; O’Connor, William T.; Fuxé, Kjell; Glennon, Jeffrey; Tanganelli, Sergio; Antonelli, Tiziana

doi:10.1016/s0306-4522(00)00448-6

Cited by 41 publications

(25 citation statements)

References 62 publications

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“…59 The mobile phase consisted of 0.1 M of sodium acetate, 10% (v/v) methanol, and 2.5% (v/v) tetrahydrofurane (pH 6.5). The LOD for glutamate was 30 fmol/sample.…”

Section: Determination Methods Of Glutamatementioning

confidence: 99%

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

Gavini

Rassu

Ferraro

et al. 2011

Journal of Pharmaceutical Sciences

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“…59 The mobile phase consisted of 0.1 M of sodium acetate, 10% (v/v) methanol, and 2.5% (v/v) tetrahydrofurane (pH 6.5). The LOD for glutamate was 30 fmol/sample.…”

Section: Determination Methods Of Glutamatementioning

confidence: 99%

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

Gavini

Rassu

Ferraro

et al. 2011

Journal of Pharmaceutical Sciences

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“…The striatal projection system arises from two distinct, but intermingled, neuronal populations (Lévesque and Parent 2005;Galvan and Wichmann 2008). One set of striatal projection neurons targets the GPi or the SNpr, whereas the other is directed toward the GPe; these projections of the striatum have been referred to as the "direct" and "indirect" striatofugal pathways, respectively (Lévesque and Parent 2005;Nadjar et al 2006;Ferraro et al 2001). The direct pathway, which is composed of GABAergic neurons that coexpress substance P and dynorphin and express the D1 dopamine receptor, projects monosynaptically to the GPi/SNpr.…”

Section: Introductionmentioning

confidence: 99%

“…The direct pathway, which is composed of GABAergic neurons that coexpress substance P and dynorphin and express the D1 dopamine receptor, projects monosynaptically to the GPi/SNpr. Both the striatopallidal and striatonigral pathways that inhibit pallidothalamic and nigrothalamic GABAergic neurons project to the VATh and lead to disinhibition of the thalamus (Hauber 1998;Ferraro et al 2001;Galeffi et al 2003;Bodor et al 2008;RangelBarajas et al 2008). The trisynaptic indirect pathway is composed of the following connections: (1) GABAergic neurons that coexpress enkephalin and the D2 dopamine receptor project from the striatum to the GPe, (2) GABAergic neurons project from the GPe to the STN, and (3) glutamatergic neurons project from the STN to GPi/ SNpr.…”

Section: Introductionmentioning

confidence: 99%

Vasoactive Intestinal Peptide (VIP) Treatment of Parkinsonian Rats Increases Thalamic Gamma-Aminobutyric Acid (GABA) Levels and Alters the Release of Nerve Growth Factor (NGF) by Mast Cells

Korkmaz

Tunçel

et al. 2009

J Mol Neurosci

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The ventral anterior nucleus of the thalamus (VATh) gathers motor information from the internal segment of the globus pallidus (GPi) and substantia nigra pars reticulata (SNpr) of the basal ganglia and projects directly to motor areas of cortex. GPi/SNpr send their tonically active gamma-aminobutyric acid (GABA)ergic outputs to VATh. The abnormal firing patterns of GABAergic neurons in GPi/SNpr lead to motor deficits. In Parkinson's disease, the spontaneous firing pattern of GPi/SNpr neurons is abnormal due to the degeneration of the nigrostriatal dopaminergic pathway. In a previous study, we found that systemically administered vasoactive intestinal peptide (VIP) was effective at reversing the motor deficits (but not the decline in striatal dopamine levels) in a rat model of Parkinson's disease (6-hydroxydopamine (6-OHDA) exposure). In addition to the beneficial effects on the motor response, VIP could also attenuate both neuronal cell death and the characteristic loss of the myelin sheath that is associated with 6-OHDA administration into the rat striatum. VIP was thought to preserve neurons by inducing native brain mast cells to adopt a nondegranulating phenotype that had the ability to secrete numerous neuroprotective substances, such as nerve growth factor (NGF) and heparin. In the present study, the effect of systemically administered VIP (25 ng/kg i.p.) was investigated on GABA levels of the VATh, dopamine/3,4-dihydroxyphenylacetic acid (DOPAC) levels in the corpus striatum, and the NGF, rat mast cell protease II (RMCPII), serotonin, and heparin content of brain mast cells in 6-OHDA-lesioned rats. Extracellular concentrations of GABA, dopamine, and DOPAC were measured by microdialysis and high-performance liquid chromatography. NGF, RMCPII, serotonin, and heparin levels were examined by immunohistochemical staining techniques. A total of 48 young adult Sprague-Dawley rats were used in the study, and these were assigned to one of six groups. Unilateral injection of 6-OHDA, 2 microl (6 mg/microl), was made into the right corpus striatum. VIP-treated animals received 25 ng/kg VIP i.p. at 2-day intervals for a period of 15 days. The present results demonstrated that VIP significantly increased the levels of GABA in the VATh that were reduced by 6-OHDA application and increased the number of NGF-immunoreactive mast cells but did not alter dopamine metabolism. Therefore, the protective effect of VIP on motor function is possibly related to the increased levels of GABA in the VATh, and its neuroprotective actions may be mediated by the release of NGF from brain mast cells.

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“…NT could influence AMP-stimulated outflow of dopamine through a dampening of D 2 receptor-mediated autoinhibition [169], since this process reportedly modulates AMPevoked dopamine release [170]. NT microinjection in the striatum also increases glutamate release [100,171], suggesting that local NT release could augment glutamate signaling, as argued above for APD responses. Finally, there are a small number of immunoreactive NT neurons along the medial border of the dorsal striatum, which could provide a local source of striatal NT [172].…”

Section: Nt Modulation Of Psychostimulant Responsesmentioning

confidence: 87%

Multitasking with neurotensin in the central nervous system

Dobner

2005

Cell. Mol. Life Sci.

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The 13-amino acid peptide neurotensin (NT) was discovered over 30 years ago and has been implicated in a wide variety of neurotransmitter and endocrine functions. This review focuses on four areas where there has been substantial recent progress in understanding NT signaling and several functions of the endogenous peptide. The first area concerns the functional activation of the high-affinity NT receptor, NTR-1, including the delineation of the NT binding pocket and receptor domains involved in functional coupling to intracellular signaling pathways. The development of NT receptor antagonists and the application of genetic and molecular genetic approaches have accelerated progress in understanding NT function in several areas, including the involvement of NT in antipsychotic drug actions, psychostimulant sensitization and the modulation of pain, and these are reviewed in that order. There is now substantial evidence indicating that NT is required for certain antipsychotic drug actions and that the peptide plays a key role in stress-induced analgesia.

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Nigral neurotensin receptor regulation of nigral glutamate and nigroventral thalamic GABA transmission: a dual-probe microdialysis study in intact conscious rat brain

Cited by 41 publications

References 62 publications

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

Vasoactive Intestinal Peptide (VIP) Treatment of Parkinsonian Rats Increases Thalamic Gamma-Aminobutyric Acid (GABA) Levels and Alters the Release of Nerve Growth Factor (NGF) by Mast Cells

Multitasking with neurotensin in the central nervous system

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