NIH3T3 transforming gene not a general feature of atherosclerotic plaque DNA

Yew, P.Renee; Rajavashisth, Tripathi B.; Forrester, James S.; Baráth, Péter; Lusis, Aldons J.

doi:10.1016/0006-291x(89)92710-1

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…36 Finally, the absence of RT, MDV, and HSV-1 sequences in the plaque-associated nude mouse tumors suggests that these viruses are not involved in the etiology of these cockerel plaques. Although one recent report failed to identify transforming activity in human carotid plaques, 42 other investigators have confirmed that serially transmitted transforming activity is present in human arteriosclerotic plaques (Reference 43 and R.M.L. Zwijsen, personal communication).…”

Section: Tumor (Ct1-3); Lane 4 Ct1-3 Primary Explant; Lane 5 Secondmentioning

confidence: 99%

Transforming potential is detectable in arteriosclerotic plaques of young animals.

Penn

Hubbard

Parkes

1991

Arterioscler Thromb

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The carcinogen-treated cockerel is a model for studying the early stages of arteriosclerotic plaque development. Carcinogen administration accelerates arteriosclerotic plaque development in cockerels, and transforming elements are present in DNA from advanced human plaques. In this study, we asked whether transforming elements could also be detected at early stages of plaque development in cockerels. Under these conditions the SMCs involved in plaque formation are regarded as indistinguishable (except for receipt of stimuli that cause proliferation) from the rest of the arterial wall SMCs. According to this view, it is the availability of mitogens or other modulators of cell division rather than any unique property of the responding arterial SMCs that determines whether intimal SMC proliferation and subsequent plaque development will occur.

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Section: Tumor (Ct1-3); Lane 4 Ct1-3 Primary Explant; Lane 5 Secondmentioning

confidence: 99%