NILAI RUJUKAN HEMATOLOGI PADA ORANG DEWASA SEHAT BERDASARKAN SYSMEX XT-1800i

Abstract

The reference values of laboratory tests are affected by factors such as instruments and methods of tests, which are always beingdeveloped. For these reasons, each laboratory is recommended to determine their own reference values. To determine the reference valuesof complete blood count in healthy adult people, and compare them to the reference values which is taken from the references. A crosssectional study was conducted on 200 healthy adult people, aged 18-60 years, selected during blood donation. The eight haematologicalparameters were estimated using Sysmex Xt-1800i at Dr.Wahidin Sudirohusodo Hospital. The data were analyzed statistically by SPSS11.5 programs. The reference values of leukocyte, erythrocyte, haemoglobin, hematocrit, MCV, MCH, MCHC and platelet were: 4400 to10000 /µL; %:4.2–6.2 × 106/µL; &:3.8–5.5 × 106/µL; %:12.5–17.3 g/dL; &:11.8–15.4 g/dL; %:38.1–50.4 %; &:31.1–49.7 %; 80,1to 94,3 fL, 25,9–31,9 pg, 31,4–35,2 g/dL, and %:171.2–405.1 × 103/µL; &:191.8–441.5 × 103/µL, respectively. Significant differenceswere observed in the MCH and platelet values (p< 0,005). The values found in this study were similar to the reference value commonlyused in our laboratory, except for the MCH value which was lower and the platelet value which was higher..

Hematologic Differences Between Migraineurs and Tension-Type Headache Patients

“…Hyperviscosity is thought to cause pain by damaging the microcirculation, causing cerebral hypoxia, reactive vasodilation and neurogenic inflammation. [ 5 , 8 ]. While low hemoglobin will cause the oxygen supply to the brain to decrease, resulting in ischemia in the muscles.…”

“…Likewise in a study conducted by Yilmaz et al (2021) which did not find a significant difference in the hematocrit value of the two groups with a hematocrit value of 40.3% in migraineurs and 41.6% in TTH patients. Normal hematocrit reference values are 41 – 50% (in men) and 30 – 44% (in women) [ 5 ]. In this study, the hematocrit values for both groups were still in the normal range.…”

“…In addition, it is the same as the research that conducted by Yilmaz et al (2021) who found that there was no significant difference in leukocyte levels between migraineurs and TTH patients with a mean leukocyte level of migraineurs 7.67 x 103/µl (SD±8.94 x 103/µl). The reference value for platelets is 4.5 – 11 x 103/µl for both men and women [ 5 ]. Leukocyte values in this study were still in the normal range.…”

“…Leukocyte values in this study were still in the normal range. Platelets play the most important role in phagocytosis and immunity to protect the body against infection or foreign bodies [ 5 ]. Migraine headaches and TTH attacks are the result of inflammation of the cerebral neurovascular and extracerebral blood vessels, this inflammatory response with an increase in the number of circulating platelets.…”

“…The relationship between hematological parameters and headaches is generally related to anemia, increased blood viscosity and other factors. In a study conducted by Evrin and Katipoglu (2019) reported there were significant differences in the Hb and Ht of migraineurs patients compared to the control group and no significant differences were found in the levels of platelets and mean platelet volume [ 5 , 6 ]. Meanwhile, in the study conducted by Gul et al (2021) showed that platelets levels were significantly higher in migraineurs than controls but no significant differences were found in other hematological parameters [ 7 ].…”