Nilotinib, a tyrosine kinase inhibitor exhibits protection against acute pancreatitis-induced lung and liver damage in rats

Nader, Manar A.; Wagih, Heba M.

doi:10.1007/s00210-016-1327-2

Cited by 5 publications

(2 citation statements)

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“…Other previous studies have shown similar findings. [60][61][62] Previous studies have shown that neutrophils and leukocytes were attracted to the site of injury as early as 3 hours after induction of pancreatitis. Infiltrating polymorphonuclear neutrophils produce oxygen-free radicals and thus cause local and systemic complications.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

IJMBOA

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Introduction: Acute pancreatitis (AP) is a disease that results in inflammation of the pancreatic tissue. The most characteristic features of this disease are activation of digestive enzymes such as amylase and lipase with subsequent release of pro-inflammatory cytokines. It may be complicated with multiorgan failure. Pulmonary complications are considered the most frequent and most serious complications. Apitherapy is a type of natural medicine that uses honey bee products like bee venom and bee propolis for treating various diseases.The aim of the study: To elucidate the apitherapeutic value of bee venom and bee propolis on L-arginine-induced acute pancreatitis and its associated lung injury complication in adult male albino rats via biological study. Materials and methods:This study was performed on 70 adult male albino rats. Rats were randomly divided into seven groups: Group I :Control group (CG), Group II :Acute pancreatitis group (AP) in which pancreatitis was induced by two intraperitoneal (i.p.) injections of 2g/kg L-arginine, 1 h apart, Group III :Bee venom (250µg/kg subcutaneous (s.c.) injection) + L-arginine treated group (BVL), Group IV: Bee propolis (300mg/kg intramuscular (i.m.) injection) + L-arginine treated group (BPL), Group V: Combined therapy group (CT), Group VI: Bee venom only treated group(BV) and Group VII: Bee propolis only treated group (BP). The diagnostic markers, including serum lipase and amylase, GGT, glucose, CRP, tissue total antioxidants and RT-PCR analysis of matrix metalloproteinase-9 (MMP-9), were measured. Histological (using hematoxylin & eosin stain) and Immunohistochemical (using NF-κB immunostain) techniques were done. The morphometric study was performed for area % and optical density of immunoexpression of NF-κB in pancreatic and lung tissues. All performed measurements were followed by statistical analysis.Results: Acute pancreatitis group revealed a significant increase in amylase and lipase serum levels, increase in MMP-9 expression and a decrease in the total antioxidants tissue content. Histopathological results demonstrated widening of the connective tissue septa of the pancreas with degeneration of pancreatic acini in AP group while, the lungs showed thickened interalveolar septa with inflammatory cellular infiltration. A significant increase in immunoreactivity of NF-κB in pancreatic and lung tissues was also observed. The pretreated groups showed a significant improvement of these biochemical and histological changes.Conclusions: There was a significant role of pretreatment with bee venom and bee propolis in ameliorating biochemical and histopathological changes in AP group.

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Section: Discussionmentioning

confidence: 99%

Untitled

2020

IJMBOA

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“…Recombinant human soluble thrombomodulin and prostaglandin E1 reduce liver and pancreas damage by maintaining the microcirculation, which improves the prognosis of SAP[ 85 , 86 ]. Nilotinib reduces pancreatic and liver damage through antioxidant and anti-inflammatory effects[ 87 ]. Heme oxygenase-1 can prevent pancreatic and liver damage through antioxidation, the maintenance of the microcirculation, and anti-inflammatory mechanisms[ 88 ].…”

Section: The Clinical Management Of Liaapmentioning

confidence: 99%

Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms

Liu¹,

Du²,

Li³

et al. 2021

WJCC

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Acute pancreatitis (AP) is a very common acute disease, and the mortality rate of severe AP (SAP) is between 15% and 35%. The main causes of death are multiple organ dysfunction syndrome and infections. The mortality rate of patients with SAP related to liver failure is as high as 83%, and approximately 5% of the SAP patients have fulminant liver failure. Liver function is closely related to the progression and prognosis of AP. In this review, we aim to elaborate on the clinical manifestations and mechanism of liver injury in patients with AP.

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