Nimodipine, a calcium channel blocker, delays the spontaneous LH surge in women with regular menstrual cycles: a prospective pilot study

Nayot, Dan; Klachook, S.; Casper, Robert F.

doi:10.1186/1477-7827-11-7

Cited by 6 publications

(7 citation statements)

References 30 publications

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“…There are still many factors affecting the success rate of IVF/ICSI, especially premature LH surges, which lead to early ovulation, causing failure in up to 20% of patients undergoing IVF/ICSI [ 2 , 3 ]. Gonadotropin-releasing hormone (GnRH) agonists and antagonist have been used to reduce surface expression of the GnRH receptor in the pituitary or reduce GnRH sensitivity to prevent premature LH surges [ 4 ]. However, such protocols have increased the incidence of ovarian hyperstimulation syndrome and these surges range from 0.34% to 38% [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Lipidomic Components Alterations of Human Follicular Fluid Reveal the Relevance of Improving Clinical Outcomes in Women Using Progestin-Primed Ovarian Stimulation Compared to Short-Term Protocol

et al. 2018

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BackgroundIncreasing the success rate of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is a duty of clinicians that has made many seek a variety of protocols. This study was undertaken to use a liquid chromatography-mass spectrometry (LC-MS) to define the alterations of follicular fluid (FF) lipid metabolites in patients undergoing progestin-primed ovarian stimulation (PPOS) compared with short-term protocol, revealing potential correlations between the differentially expressed lipids and ameliorative clinical outcomes.Material/MethodsNinety-three infertile women undergoing IVF/ICSI treatment with PPOS (n=62) or a short-term protocol (n=31) were prospectively enrolled in a randomized controlled trial. FF samples were obtained from dominant follicles at the time of oocyte retrieval. Lipid metabolism profiles were analyzed using LC-MS.ResultsTwelve lipids were found to be higher in patients treated with the PPOS protocol than in those receiving the short-term protocol, including triacylglycerols (TAG-34: 1+NH4, TAG-58: 0+NH4, TAG-64: 3+NH4, and TAG-64: 8+NH4), diacylglycerol DAG-38: 6+NH4, phosphatidylglycerols (PG-26: 0, PG-30: 2, and PG-40: 5), phosphatidylethanolamine PE-32: 2, lysophosphatidylethanolamine LPE-14: 1, lysophosphatidylinositol LPI-12: 0, and lysophosphatidylcholine LPC-16: 0.ConclusionsOur data demonstrate that the PPOS protocol increases the levels of 12 lipids in FF, which reveals a strong association between the differentially elevated lipids and better IVF/ICSI outcomes.

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Section: Introductionmentioning

confidence: 99%

Lipidomic Components Alterations of Human Follicular Fluid Reveal the Relevance of Improving Clinical Outcomes in Women Using Progestin-Primed Ovarian Stimulation Compared to Short-Term Protocol

et al. 2018

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“…In the study by Cantineau and Cohlen, LH surge was found among only one-third of women who were recruited for ovulation induction (20) while LH surge was observed among less than a quarter of women in the nimodipine group. Additionally, Nayot et al reported that taking 60 mg nimodipine 3 times daily for four days prevents LH surge among women with a regular menstrual cycle (15). The increase in the serum level of LH in the nimodipine group in the above-mentioned study might be due to the dosage of the drug since, in their study, women took a 180 mg daily dosage of nimodipine while, in the present study, participants took a 90 mg daily dosage.…”

Section: Discussionmentioning

confidence: 48%

“…A recent publication has demonstrated that nimodipine could be used as a costeffective oral medication which effectively suppresses the release of GnRH and thus reduces the premature LH surge in women undergoing IUI. The resulted suggest that the nimodipine may lead to better success following the treatment with IUI and higher rates of a successful pregnancy (15).…”

Section: Introductionmentioning

confidence: 98%

“…Nimodipine is a lipophilic calcium channel blocker that is used to prevent the spontaneous LH surge and an increase in the premature LH in women. It inhibits the pulsatile activity of GnRH gene expression and the influx of extracellular calcium and subsequently the stimulation of GnRH release (15,16). A recent publication has demonstrated that nimodipine could be used as a costeffective oral medication which effectively suppresses the release of GnRH and thus reduces the premature LH surge in women undergoing IUI.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Nimodipine on Premature Luteinizing Hormone Surge in Women Undergoing Intrauterine Insemination

Razghandi

Taheripanah

Heidar

2020

International Journal of Women’s Health and Reproduction Scienc

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Objectives: To determine the effect of nimodipine on premature luteinizing hormone (LH) surge in women undergoing intrauterine insemination (IUI). Patients and Methods: Fifty-six infertile women participated in this randomized clinical trial after referring to Mahdiyeh hospital, Tehran, Iran and undergoing IUI treatment in 2017. Participants were randomly divided into nimodipine (n=34) and placebo (n=22) groups. The demographic and clinical profile of women were collected using a predesigned checklist. In the nimodipine group, 30 mg tablets were given to patients three times daily for 2 days. Finally, the serum levels of LH and estradiol were measured before and after the intervention. Results: Based on the results, the LH surge was observed in 8 (34.8%) women in the placebo group (P=0.04) while it was not detected in 29 (78.4%) women in the nimodipine group. There were no statistical differences in the serum levels of estradiol and LH between the 2 groups before the intervention. The serum levels of estradiol in both groups increased after intervention although this increase was not significant. Eventually, no statistical difference was found between the 2 groups in terms of fertility rate. Conclusions: In general, nimodipine can significantly reduce premature LH surge in patients undergoing IUI compared to the placebo group.

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“…Other strategies include administration of GnRH antagonists,[ 7 ] ethinyl estradiol (E 2 ) plus norethindrone,[ 8 ] mifepristone,[ 9 ] and nimodipine. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

Effects of clomiphene citrate for prevention of premature luteinizing hormone surge in those undergoing intrauterine insemination outcome: A randomized, double-blind, placebo-controlled trial

Zarei

Alborzi

Askary

et al. 2018

J Adv Pharm Technol Res

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The objective of the study is to determine the effects of clomiphene citrate (CC) on preventing premature luteinizing hormone (LH) surge in infertile patients with polycystic ovary syndrome (PCOS) undergoing intrauterine insemination (IUI). This was a randomized clinical trial being performed at Shiraz Mother and Child Hospital. We included 162 women with PCOS selected for IUI cycles. Patients were randomly allocated to receive 150 mg/day CC from the 8th of the cycle though the day of human chorionic gonadotropin (hCG) injection (n = 81) or nothing in the same period (n = 81). Main outcomes included the incidence of premature LH surge, pregnancy rate, abortion and ongoing pregnancy rates, number of maturing follicles, and endometrial thickness. The incidence of premature LH surge was significantly lower in those who received CC (3.0% vs. 14.9%; P = 0.021). The pregnancy rate was 10 (15.1%) and 6 (8.9%) in CC and control groups, respectively (P = 0.342). The ongoing pregnancy rate found to be comparable between two study groups (12.1% vs. 5.9%; P = 0.068). Serum level of estradiol (E2) level at the time of hCG administration was significantly higher in those who were treated with CC when compared to control (1153.5 ± 326.4 vs. 943.2 ± 215.3; P < 0.001). Patients who received CC also had higher number of mature follicles >18 mm when compared to controls (3.85 ± 1.3 vs. 2.94 ± 1.01; P < 0.001). Administration of CC from the 8th day of the cycle to the day of hCG injection in combination with Gonal-f in infertile patients with CC-resistant PCOS undergoing IUI cycles is associated with decreased incidence of premature LH surge, higher E2levels, and higher number of mature ovarian follicles. This protocol is safe and simple and could be considered to be cost-effective.

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Nimodipine, a calcium channel blocker, delays the spontaneous LH surge in women with regular menstrual cycles: a prospective pilot study

Cited by 6 publications

References 30 publications

Lipidomic Components Alterations of Human Follicular Fluid Reveal the Relevance of Improving Clinical Outcomes in Women Using Progestin-Primed Ovarian Stimulation Compared to Short-Term Protocol

Lipidomic Components Alterations of Human Follicular Fluid Reveal the Relevance of Improving Clinical Outcomes in Women Using Progestin-Primed Ovarian Stimulation Compared to Short-Term Protocol

Effect of Nimodipine on Premature Luteinizing Hormone Surge in Women Undergoing Intrauterine Insemination

Effects of clomiphene citrate for prevention of premature luteinizing hormone surge in those undergoing intrauterine insemination outcome: A randomized, double-blind, placebo-controlled trial

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