Nine triterpenes from Boswellia sacra Flückiger and their chemotaxonomic importance

Al‐Harrasi, Ahmed; Ali, Liaqat; Rehman, Najeeb Ur; Hussain, Hidayat; Al‐Rawahi, Ahmed; Langley, G. John; Wells, Neil J.; Abbas, Ghulam

doi:10.1016/j.bse.2013.08.026

Cited by 26 publications

(14 citation statements)

References 29 publications

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“…Isomer 22 was isolated from B . sacra earlier [ 72 ]. In a similar analogy to alcohol 14 , alcohol 20 is a result of the oxidation of the amyrin 19 .…”

Section: Resultsmentioning

confidence: 99%

Chemical, molecular and structural studies of Boswellia species: β-Boswellic Aldehyde and 3-epi-11β-Dihydroxy BA as precursors in biosynthesis of boswellic acids

et al. 2018

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The distribution and biosynthesis of boswellic acids (BAs) is scarce in current literature. Present study aims to elucidate the BAs biosynthetic and its diversity in the resins of Boswellia sacra and Boswellia papyrifera. Results revealed the isolation of new (3β, 11β-dihydroxy BA) and recently known (as new source, β-boswellic aldehyde) precursors from B. sacra resin along with α-amyrin. Following this, a detailed nomenclature of BAs was elucidated. The quantification and distribution of amyrins (3-epi-α-amyrin, β-amyrin and α-amyrin) and BAs in different Boswellia resins showed highest amyrin and BAs in B. sacra as compared with B. serrata and B. papyrifera. Distribution of BAs significantly varied in the resin of B. sacra collected from dry mountains than coastal trees. In B. sacra, high content of α-amyrin was found in the roots but it lacked β-amyrin and BAs. The leaf part showed traces of β-ABA and AKBA but was deficient in amyrins. This was further confirmed by lack of transcript accumulation of amyrin-related biosynthesis gene in leaf part. In contrast, the stem showed presence of all six BAs which are attributed to existence of resin-secretory canals. In conclusion, the boswellic acids are genus-specific chemical constituents for Boswellia species albeit the variation of the amounts among different Boswellia species and grades.

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“…Isomer 22 was isolated from B . sacra earlier [ 72 ]. In a similar analogy to alcohol 14 , alcohol 20 is a result of the oxidation of the amyrin 19 .…”

Section: Resultsmentioning

confidence: 99%

Chemical, molecular and structural studies of Boswellia species: β-Boswellic Aldehyde and 3-epi-11β-Dihydroxy BA as precursors in biosynthesis of boswellic acids

et al. 2018

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“…Therefore, the urease inhibitors have attracted the attention as much safer potential anti-ulcer drugs [24,25]. and their charachetrization [1,7].…”

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confidence: 99%

“…Frankincense is particularly vital as its aroma has significance for religious practices since the time of ancient Egyptians and these resins have also shown therapeutic properties [3,4]. It has great medicinal value and commonly used to treat various problems related to digestion, respiration, stomach, dental infections, fever, cough and muscle pain [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of essential oils from Boswellia sacra and Teucrium mascatense against acetyl cholinesterase enzyme and urease enzyme

Abbas¹,

Albroumi²,

Rehman³

et al. 2017

ijpm

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Enzyme inhibition is one of the most important areas of pharmaceutical research which resulted in the discoveries of several useful drugs. The prime aim of this study is to identify effective natural inhibitors against pharmacologically important enzymes such as acetylcholinesterase enzyme and urease enzyme. In present study, we evaluated the essential oils extracted from medicinally important plants including Boswellia sacra Flückiger (frankincense) and Teucrium mascatense Boiss. Two major constituents of frankincense essential oil including (+)-α-pinene and (R)-+-limonene were also investigated against these enzymes. The essential oils were extracted from Boswellia sacra and Teucrium mascatense which are native plants to the southern and northern areas of Oman, respectively. In this study, the essential oil of frankincense exhibited significant inhibition with IC50 value of 0.043±0.02 mg/mL, against acetylcholinesterase enzyme while against urease enzyme it has shown good inhibition with IC50 value of 0.17 ± 0.05 mg/mL. The essential oil obtained from the Teucrium mascatense was found to be in active against both the enzymes. On acetylcholinesterase enzyme inhibition assay, the (+)-α- pinene exhibited significant inhibition (IC50 = 0.094±0.01 mg/mL) while (R)-+- limonene was found to be inactive on this assay. Against urease enzyme (+)-α- pinene and (R)-+- limonene showed moderate activity 40.06±1.03 % and 19.5±1.00 %, respectively. Interestingly, the mixture of equal concentration of (+)-α- pinene and (R)-+- limonene exhibited 70% inhibition with IC50 value of (0.195 ± 0.10 mg/mL) which shows the synergistic relationship between them. Promising inhibitory potential of frankincense essential oil and (+)-α-pinene, against acetylcholinesterase enzyme and urease enzyme indicated their potential therapeutic role to manage Alzheimer’s disease and stomach ulcers, respectively.

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“…Aromatic plant species of family Burceraceae are important medicinal plants which are recommended for reducing occurrence of dental caries due to a range of therapeutic properties of their extracts and essential oils. Frankincense or Olibanum is an oleo-gum resin obtained from several species of the genus Boswellia, a member of the Burseraceae family of aromatic plants [2]. This complex material generally contain 5-9% essential oil, 65-85% alcohol-soluble resin, and the remaining water soluble gum (polysaccharide fraction) [3], the Myrrh which occurs in the same family Burceraceae is an oleo-gum resin exudates obtained from several species in the genus Commiphora, it contains 57-61% water-soluble gum, 7-17% volatile oils,25-40% alcoholsoluble resins and 3-4% impurities [4].…”

Section: Introductionmentioning

confidence: 99%

“…Frankincense or Olibanum is an oleo-gum resin obtained from several species of the genus Boswellia, a member of the Burseraceae family of aromatic plants [2]. This complex material generally contain 5-9% essential oil, 65-85% alcohol-soluble resin, and the remaining water soluble gum (polysaccharide fraction) [3], the Myrrh which occurs in the same family Burceraceae is an oleo-gum resin exudates obtained from several species in the genus Commiphora, it contains 57-61% water-soluble gum, 7-17% volatile oils,25-40% alcoholsoluble resins and 3-4% impurities [4]. C.myrrha is an effective antimicrobial agent used in the treatment of mouth ulcers, gingivitis, sinusitis, glandular fever, brucellosis and as an anti-parasitic agent [5], [6].…”

Section: Introductionmentioning

confidence: 99%

Anti-Bacterial Activities of Crude Extract of Some East African Oleo Gum Resins (Burceraceae) and their Respective Extraction Yield

2014

International Conference on Chemical, Environment &Amp; Biological Sciences (CEBS-2014) Sept. 17-18, 2014 Kuala Lumpur (Malaysi

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The present study is focus on anti-bacterial effects of methanol, acetone and hexane crude extracts of Boswellia-frereana, Boswellia-carterii, and Commiphora-myrrha in order to screen their inhibitory growth activities on streptococcus mutans and lactobacillus spp. Methanol extracts in all three oleo gum resins displayed anti-microbial activity against the tested bacterial strains while acetone and hexane extracts exhibited minimal activities respectively. B.frereana-methanol extract gave highest result with 19mm inhibition zone on tested bacteria. B.frereana-acetone and C.myrrha-acetone extracts gave 17mm and 15mm growth inhibition zone respectively. Hexane extracts generally gave low antimicrobial activity. Methanol extract gave highest yield of 68% for B.carterii, 30% for C.myrrha, and 65% for B.frereana. Hexane extraction gave 90% yield for B.frereana while 10% yield was recorded on C.myrrha. Methanol was selected as best solvent for yield and biological activity while B.frereana and C.myrrha showed highest efficiencies for biological activities respectively in both methanol and acetone solvents.

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Nine triterpenes from Boswellia sacra Flückiger and their chemotaxonomic importance

Cited by 26 publications

References 29 publications

Chemical, molecular and structural studies of Boswellia species: β-Boswellic Aldehyde and 3-epi-11β-Dihydroxy BA as precursors in biosynthesis of boswellic acids

Chemical, molecular and structural studies of Boswellia species: β-Boswellic Aldehyde and 3-epi-11β-Dihydroxy BA as precursors in biosynthesis of boswellic acids

Evaluation of essential oils from<em> Boswellia sacra</em> and <em>Teucrium mascatense</em> against acetyl cholinesterase enzyme and urease enzyme

Anti-Bacterial Activities of Crude Extract of Some East African Oleo Gum Resins (Burceraceae) and their Respective Extraction Yield

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