Ninety-Five cases of intestinal transplantation at the University of Miami

Structural Shifts of Fecal Microbial Communities in Rats with Acute Rejection after Liver Transplantation

“…Nevertheless, morbidity and mortality due to rejection and infectious complications remain as major problems following transplantation [2]. Deaths are often related to sepsis, and most infectious episodes are associated with rejection [3,4].…”

Inducible Nitric Oxide Synthase Expression in the Intestinal Muscularis Mediates Severe Smooth Muscle Dysfunction During Acute Rejection in Allogenic Rodent Small Bowel Transplantation

“…The cause for this is due to the loss of mucosal integrity and mucosal barrier of the gut during acute rejection, which makes the bowel susceptible for bacterial translocation and endotoxemia. As the host immunosystem becomes further compromised with additional and inevitable anti-rejection therapies, possible consequences often include systemic inflammatory response syndrome, sepsis, and multi-organ failure [5][6][7][8]. Impairment of smooth muscle contractility as a consequence of rejection processes in the muscularis propria of the small bowel is another potential factor promoting bacterial overgrowth and translocation.…”

Intestinal transplantation for short bowel syndrome secondary to gastroschisis

“…Medical records for all patients were reviewed regarding delivery gestation age, body weight at birth, mode of delivery, prenatal diagnosis, associated anomaly, family history, birth place, sex, race, mother's age, pretransplant surgical history (age at the time of gastroschisis repair, mode of gastroschisis repair, size of abdominal wall defect, reason for bowel resection, age at the time of bowel resection, length of remain bowel), transplant surgery (age at the time of transplant, types of graft received, year transplanted), and outcome after transplant (length of follow-up, and patient and graft survival). Transplant procedures were performed as previously described [11][12][13][14]. Baseline immunosuppression included tacrolimus and corticosteroids in all cases.…”