Ninjin'yoeito (Tsumura) Extract; a Kampo (traditional herbal medicine) Improved Apathy in a Mild Cognitive Impairment Patient

Sato, Shinji; Tamura, Masashi; Takahashi, Takumi; Arai, Tetsuaki

doi:10.5234/cnpt.9.17

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…NYT is typically prescribed as oral medication in Japan. NYT is a multicomponent drug that includes 12 crude herbs and plant products: rehmannia root, angelica root, atractylodes rhizome, Poria sclerotium, ginseng, cinnamon bark, polygala root, peony root, citrus unshiu peel, astragalus root, glycyrrhiza, and schisandra fruit [ 6 , 26 , 27 ]. Thus far, NYT has been shown to ameliorate muscle-related complications in cancer-bearing mice and chronic obstructive pulmonary disease model mice [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Effects of Ninjin’yoeito on Physical Frailty in Mice

Otsuka

Fukumaru

Tani

et al. 2022

IJMS

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Physical frailty is an aging-related clinical syndrome involving decreases in body weight, mobility, activity, and walking speed that occurs in individuals with sarcopenia and is accelerated by increased oxidative stress. Ninjin’yoeito, a traditional Japanese Kampo medicine, is used for treating conditions, including anemia and physical weakness. Here, we investigated whether ninjin’yoeito could improve physical frailty by controlling oxidative stress in the senescence-accelerated mouse prone 8 (SAMP8) model. First, SAMP8 mice were divided into two groups, ninjin’yoeito treated and untreated, with the former consuming a diet containing 3% ninjin’yoeito from 3 months of age. At 7 months of age, body weight, motor function, locomotor activity, and mean walking speed were measured. Subsequently, mice were euthanized and measured for muscle weight, 8-hydroxy-2′-deoxyguanosine levels in muscle and brain, and cleaved caspase-3 expression in brain. The results showed reductions in weight, locomotor function, locomotion, and average walking speed in the untreated group, which were significantly improved by ninjin’yoeito. Furthermore, 8-hydroxy-2′-deoxyguanosine levels were reduced in muscle and brain from ninjin’yoeito-treated mice, compared with the levels in untreated mice; cleaved caspase-3 expression was similarly reduced in brain from the treated mice, indicating reduced apoptosis. Our findings suggest that ninjin’yoeito inhibits sarcopenia-based physical frailty through its antioxidant effects.

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