Nintedanib for treatment of progressive interstitial lung disease after peripheral blood stem cell transplantation in a patient with recurrent acute lymphoblastic leukemia

Kouroki, Masahiko; Inagaki, Jiro; Fujisaki, Toru; Matsuishi, Toshiya; Sato, Tetsuji; Kamizono, Junji; Yasui, Masayoshi

doi:10.1002/pbc.29211

Cited by 2 publications

(1 citation statement)

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“…Sorafenib works by stopping the progression of cancer and blocking the therapeutic replication of potentially malignant cells [ 49 ]. Nintedanib is a small-molecule kinase inhibitor that competitively inhibits both non-receptor tyrosine kinases and receptor tyrosine kinases, and these inhibitory effects increase fibroblast proliferation, migration, and transformation [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Genes and Associated Drugs in Cervical Cancer by Bioinformatics Methods

et al. 2022

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Background Cervical cancer is one of the common gynecological tumors that seriously harm women’s health, so it is particularly important to accurately explore the underlying mechanism of its occurrence and clinical prognosis. Material/Methods In the GEO database, GEO2R was used to analyze the differentially expressed genes from the 4 databases: GSE6791, GSE9750, GSE63514, and GSE67522. Then, the DAVID website was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. These protein–protein interaction (PPI) networks of DEGS were visualized and analyzed using the STRING website and the hub genes were further screened using the Cytohubba plugin. Lastly, the functions of the hub genes were further analyzed by Gene Expression Profiling Interactive Analysis (GEPIA) online tools, Human Protein Atlas (HPA) databases, and the QuartataWeb database. Results In the 4 Profile datasets, 101 cancer tissues and 67 normal tissues were collected. Among the 78 differentially expressed genes in the 4 datasets, 51 genes were upregulated and 27 genes were downregulated. The PPIs of these differentially expressed genes were visualized using Cytoscape and the Interaction Gene Search Tool (STRING). Then, further analysis of hub genes using the GEPIA tool and Kaplan-Meier curves that showed upregulation of CDK1 and PRC1 is associated with better survival, while AURKA is associated with worse survival. Among these hub genes, only AURKA was closely related to the prognosis of cervical cancer, and 21 potential drugs were found. Conclusions These results suggest that AURKA and its drug candidates can improve the individualized diagnosis and treatment of cervical cancer in the future.

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Section: Discussionmentioning

confidence: 99%