2023
DOI: 10.3390/life13051076
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Niosomal Curcumin Suppresses IL17/IL23 Immunopathogenic Axis in Skin Lesions of Psoriatic Patients: A Pilot Randomized Controlled Trial

Abstract: Psoriasis (PS) is characterized by hyperplasia of epidermis and infiltration of immune cells in the dermis. A negligible susceptibility of hypodermic permeation for local anti-inflammatory remedies is one of the major causes of medication failures. Although curcumin (CUR) has indicated effectiveness in treatment of inflammation, its successful permeation through the stratum corneum is yet a challenging issue. Therefore, niosome (NIO) nanoparticles were used as curcumin carriers to enhance its delivery and anti… Show more

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Cited by 3 publications
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“…Significant reduction in redness and scaling; significant downregulation of proinflammatory cytokines [191] PASI, Psoriasis Area and Severity Index.…”
Section: Clinical Studies On Nanocarriers Containing Anti-psoriatic D...mentioning
confidence: 99%
See 1 more Smart Citation
“…Significant reduction in redness and scaling; significant downregulation of proinflammatory cytokines [191] PASI, Psoriasis Area and Severity Index.…”
Section: Clinical Studies On Nanocarriers Containing Anti-psoriatic D...mentioning
confidence: 99%
“…In summary, curcumin-containing niosomes may provide an effective therapeutic approach for this cohort of patients. The niosomal gel could potentially enhance the therapeutic outcome of PSO skin lesions and promote the healing process as a topical treatment [ 191 ].…”
Section: Clinical Studies On Nanocarriers Containing Anti-psoriatic D...mentioning
confidence: 99%