Niosomal drug delivery for transdermal targeting: recent advances

Muzzalupo, Rita; Tavano, Lorena

doi:10.2147/rrtd.s64773

Cited by 109 publications

(81 citation statements)

References 46 publications

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“…12. They improve the therapeutic profile of the drug molecules due to delayed clearance from the circulation 4,5 .…”

Section: Types Of Niosomesmentioning

confidence: 99%

Niosomes: Present Scenario and Future Aspects

Kaur¹,

Kumar²

2018

J. Drug Delivery Ther.

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Drug targeting is a kind of phenomenon in which drug gets distributed in the body in such a manner that the drug interacts with the target tissue at a cellular or subcellular level to achieve a desired therapeutic response at a desire site without undesirable interactions at other sites. This can be achieved by modern methods of targeting the drug delivery system such as niosomes. Niosomes are the type of non-ionic surfactant vesicles, which are biodegradable, non-toxic, more stable and inexpensive, a new approach to liposomes. Their structure similar to liposome and hence they can represent alternative vesicular systems with respect to liposomes. The niosomes have the tendency to load different type of drugs. This review article represents the structure of niosome, advantages, disadvantages, the methods for niosome preparation and characterization of pharmaceutical NSVs. Keywords: Niosome, Cholesterol, Hydrophilic and Lipophilic drugs, Surfactant, Targeted delivery Bioavailability Improvement, Factors, Applications.

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“…12. They improve the therapeutic profile of the drug molecules due to delayed clearance from the circulation 4,5 .…”

Section: Types Of Niosomesmentioning

confidence: 99%

Niosomes: Present Scenario and Future Aspects

Kaur¹,

Kumar²

2018

J. Drug Delivery Ther.

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“…Niosomes are lamellar (bilayer) structures, similar to liposomes, composed of non-ionic surfactant molecules surrounding an aqueous compartment [88]. In ocular delivery, lamellar structures are favored over vesicular system because chemically they are stable; raw materials are easily available and less expensive; unlike phospholipids, does not require any conditions and precautions for handling of surfactants, which make them more attractive for industrial manufacturing; they are biocompatible, biodegradable, and non-immunogenic [89].…”

Section: Niosomesmentioning

confidence: 99%

Diabetic Retinopathy: An Inclusive Review on Current Treatment and Management Approaches

Jyothi

2018

Asian J Pharm Clin Res

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Diabetic retinopathy (DR) is a complication which occurs due to diabetes mellitus leading to loss of vision and hindering the quality of patient life by damaging the layer of retina at the posterior segment of the eye. According to the survey around 285 million peoples are suffering from visual loss out of these 65% of people are more than 50 years old and 82% of blind patients are more than 50 years old. The diseases that occur in the posterior segment of the eye like, cytomegalovirus retinitis, posterior uveitis, age related macular degeneration and diabetic retinopathy needs a novel delivery system that can improve the concentration of drugs that reaches posterior segment of the eye. The development of new drug delivery system gained more importance in the field of research in which nanotechnology is the most considered approach. The nanotechnology-based systems such as nanoparticles, nanoliposomes, niosomes, nanomicelles, nanoemulsions, nanogels, cyclodextrins, dendrimers, and quantum dots are developed as a new formulation for drug delivery. The rationale behind the nanoparticle systems is its ability to formulate a sustained, controlled release dosage form, painless, safe, non-invasive system to overcome the major barriers in the treatment of DR. Based on the nanoparticles, some approaches are exploited for more effective conveyance of drug toward the posterior segment. Thus, these advanced delivery systems progress the therapeutic efficacy of the drug and patient’s obedience and life quality. In this review, the new therapeutic treatments and their managements were discussed and methods of drug delivery to reach the posterior segment of eye.

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“…The main advantages of using niosomes as topical drug delivery systems arise from their peculiar features, such as their small size, composition and architecture. In addition these vesicles have been claimed to serve as a local depot for sustained drug release, permeation enhancers of dermally active compounds or as rate-limiting barrier for the modulation of systemic absorption of drugs [24].…”

Section: Percutaneous Permeation Studiesmentioning

confidence: 99%

Tetracycline-niosomes versus Tetracycline Hydrochloride-niosomes: How to Modulate Encapsulation and Percutaneous Permeation Properties

Tavano¹

2017

J. Drug

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Nowdays, the design of the optimalniosomal formulation may ensure the best performance in terms of physico-chemical properties and drug skin permeation. Our study want to propose the loading of Tetracycline or Tetracycline hydrocholoride drugs as strategy to modulate niosomes properties, with particular emphasis on encapsulation and percutaneous permeation behavior. Niosomes were prepared from mixtures of nonionic commercial surfactants with different final value of hydrophilelipophile balance (HLB). Significant increase in size respect to the corresponding empty vesicles occurred when drugs were encapsulated, while the presence of glyceryl monostearate resulted in a reduction of the diameter. Drugs entrapment efficiencies were found to be directly related to the chemical properties of the system: tetracycline showed better affinity for lipophilic matrices, while tetracycline hydrochloride was better encapsulated in hydrophilic ones. Finally we found drugs permeation across the skin was affected by many variables, such as bilayer composition, niosomes size, nature of the drugs and their entrapment efficiency, where by depending on the intended effect (topical or systemic) the opportune formulation may be selected.

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Niosomal drug delivery for transdermal targeting: recent advances

Cited by 109 publications

References 46 publications

Niosomes: Present Scenario and Future Aspects

Niosomes: Present Scenario and Future Aspects

Diabetic Retinopathy: An Inclusive Review on Current Treatment and Management Approaches

Tetracycline-niosomes versus Tetracycline Hydrochloride-niosomes: How to Modulate Encapsulation and Percutaneous Permeation Properties

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