Niosome-loaded antifungal drugs as an effective nanocarrier system: A mini review

Osanloo, Mahmoud; Assadpour, Sara; Mehravaran, Ahmad; Abastabar, Mahdi; Akhtari, Javad

doi:10.18502/cmm.4.4.384

Cited by 21 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In extracellular oxidative environments, disulfide bonds are stable, but, once in a reductive intracellular environment, they are easily cleaved [ 18 ]. Cholesterol-based drug delivery systems such as niosomes do not have a chemical reaction between the non-ionic surfactants and cholesterol but the components are rather mixed in ratios to give dispersions and gels [ 23 , 24 ].…”

Section: Cholesterol and Its Function As A Drug Carriermentioning

confidence: 99%

“…Niosomes are lamellar vesicles which are able to form colloids and they are prepared from mixing non-ionic surfactants and cholesterol [ 108 ]. The cholesterol used for the preparation of niosomes is useful for the maintenance of the rigidity and shape while the surfactant mainly provides a hydrophilic core for the localization of the hydrophilic drugs [ 24 ]. Niosomes are used as drug delivery system for hydrophilic and hydrophobic drugs.…”

Section: Cholesterol-based Compounds In Transdermal Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

The Efficacy of Cholesterol-Based Carriers in Drug Delivery

Ruwizhi

Aderibigbe

2020

Molecules

View full text Add to dashboard Cite

Several researchers have reported the use of cholesterol-based carriers in drug delivery. The presence of cholesterol in cell membranes and its wide distribution in the body has led to it being used in preparing carriers for the delivery of a variety of therapeutic agents such as anticancer, antimalarials and antivirals. These cholesterol-based carriers were designed as micelles, nanoparticles, copolymers, liposomes, etc. and their routes of administration include oral, intravenous and transdermal. The biocompatibility, good bioavailability and biological activity of cholesterol-based carriers make them potent prodrugs. Several in vitro and in vivo studies revealed cholesterol-based carriers potentials in delivering bioactive agents. In this manuscript, a critical review of the efficacy of cholesterol-based carriers is reported.

show abstract

Section: Cholesterol and Its Function As A Drug Carriermentioning

confidence: 99%

Section: Cholesterol-based Compounds In Transdermal Drug Deliverymentioning

confidence: 99%

The Efficacy of Cholesterol-Based Carriers in Drug Delivery

Ruwizhi

Aderibigbe

2020

Molecules

View full text Add to dashboard Cite

show abstract

“…Serving as a local (isolated) drug depot and providing a mechanism for controlled release, such systems can deliver high topical concentrations of drugs without pronounced systemic spread [54]. Thus, systems such as polymeric films [55], nano- and microemulsions [56], vesicular carriers [57] (including liposomes [58], ethosomes [59], transethosomes [60], and niosomes [61]), solid lipid [62] and polymeric particles [63], and porous inorganic carriers [64, 65] were proposed and investigated for antifungal agents’ penetration promotion.…”

Section: Nanocarriers For Intradermal Permeation and Antimycotic Actimentioning

confidence: 99%

Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs

Lengert¹,

Тальникова²,

Tuchin³

et al. 2020

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Topical therapy of superficial fungal infections allows the prevention of systemic side effects and provides drug targeting at the site of disease. However, an appropriate drug concentration in these sites should be provided to ensure the efficacy of such local treatment. The enhancement of intra- and transdermal penetration and accumulation of antifungal drugs is an important aspect here. The present overview is focused on novel nano-based formulations served to improve antimycotic penetration through the skin. Furthermore, it summarizes various approaches towards the stimulation of drug penetration through and into the stratum corneum and hair follicles, which are considered to be promising for the future improvement of superficial antifungal therapy as providing the drug localization and prolonged storage property at the targeted area.

show abstract

“…The epidermis is the target place of pathogens for accumulation and proliferation. The treatment should include proper topical formulations that can release a sufficient amount of drug in therapeutic concentrations and permeate through higher layers of the skin, like the stratum corneum, to achieve suitable treatment [10,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Nanoliposome-loaded antifungal drugs for dermal administration: A review

Asadi

Mehravaran

Soltanloo

et al. 2021

CMM

Self Cite

View full text Add to dashboard Cite

Cutaneous fungal infections are the fourth most common health problem, which involves approximately billion people worldwide. Drug delivery to the skin seems to be the best choice for superficial fungal infections. Topical formulations can release a sufficient amount of drug in therapeutical concentrations and permeate higher layers of the skin like the stratum corneum. As the outermost layer of the epidermis, the stratum corneum prevents the drug from penetrating the skin. Liposomes, especially nanosized as topical drug delivery systems to the skin, can show various functions depending on their size, lipids and cholesterol components, the percent of ingredients, lamellarity, and surface charge. Nanoliposomes can increase permeation through the stratum corneum, decrease systemic effects with their localizing actions, and overcome many dermal drug delivery obstacles. Antifungal drugs, such as croconazole, econazole, fluconazole, ketoconazole, terbinafine hydrochloride, tolnaftate, and miconazole entrapped in liposomes have indicated improved skin penetration and localizing effects. According to the literature review summarized in this paper, many studies have identified liposomes as a powerful carrier for topical antifungal drug delivery to the skin. However, a few studies introduced new generations of liposomes like ethosomes and transfersomes. This paper was conducted on almost all liposomal studies of antifungal drugs with dermal application.

show abstract

Niosome-loaded antifungal drugs as an effective nanocarrier system: A mini review

Cited by 21 publications

References 31 publications

The Efficacy of Cholesterol-Based Carriers in Drug Delivery

The Efficacy of Cholesterol-Based Carriers in Drug Delivery

Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs

Nanoliposome-loaded antifungal drugs for dermal administration: A review

Contact Info

Product

Resources

About