Nipple Adenoma: A Benign Disease With a Suspicious Presentation

Rodriguez, Paula Porras; Crabtree, Matthew; Venegas, Rose; Ozao‐Choy, Junko; Dauphine, Christine

doi:10.1177/00031348221117026

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…This rare entity, which accounts for just 1–1.7% of benign breast lesions [ 13 ], can include various histological patterns. The main histological feature is the ductal proliferation of glandlike structures within the stroma of the nipple, with well-circumscribed margins without encapsulation [ 7 , 12 – 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although nipple adenoma represents a rare benign neoplasm, the main issue is the differential diagnosis with nipple Paget's disease, DCIS of low-grade, syringomatous adenoma, and subareolar solitary central papilloma [2,3]. This rare entity, which accounts for just 1-1.7% of benign breast lesions [13], can include various histological patterns. The main histological feature is the ductal proliferation of glandlike structures within the stroma of the nipple, with well-circumscribed margins without encapsulation [7,[12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…This rare entity, which accounts for just 1-1.7% of benign breast lesions [13], can include various histological patterns. The main histological feature is the ductal proliferation of glandlike structures within the stroma of the nipple, with well-circumscribed margins without encapsulation [7,[12][13][14][15]. Confirmation of the presence of at least two distinct layers of myoepithelial cells in neoplastic ducts seems to be the most important finding for the differential diagnosis of ductal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Management of nipple adenomas during pregnancy: a case report

et al. 2023

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Background Nipple adenoma is a very uncommon, benign neoplasm that involves the nipple. A palpable mass of the nipple associated with nipple discharge and erosion or ulceration is the common clinical presentation. Generally, complete surgical excision of the nipple is the main treatment, alternative therapeutic methods such as Mohs micrographic surgery, nipple splitting enucleation, and cryotherapy can be considered. Disorders of the breast in young women are generally benign. Even if the management during pregnancy is usually conservative and surgical excision is reserved for very strong malignancy suspicion, benign lesions can cause the impossibility to breastfeed after giving birth when involving the nipple. Case presentation We present the case of a 28-year-old female, who was referred to the Breast Unit of the University Hospital of Modena (Italy) in May 2020 with a 12-months history of enlargement of the left nipple with associated erythema, serohemorrhagic discharge, and pain in the left nipple region. The diagnostic assessment came out in favor of a nipple adenoma. After surgical treatment was recommended, the patient got pregnant. Taking into account the major risks of surgery during pregnancy, a multidisciplinary discussion was conducted, to consider whether to proceed with surgery or postpone it after pregnancy. Because of the volume and the position of the adenoma, the indication for surgical excision was confirmed, to allow regular lactation and breastfeeding immediately after giving birth and to avoid potential obstructive complications. Surgical excision of nipple adenoma without complete resection of the nipple was performed after her first trimester of pregnancy under local anesthesia. A histopathological examination confirmed the diagnosis. No recurrence occurred after 12 months. The patient gave birth, had no deficit in lactation, and successfully breastfed. Conclusions Therefore, we consider that nipple adenoma enucleation might be a safe treatment even during pregnancy. Moreover, conservative local treatment of nipple adenomas can preserve the nipple aesthetically and functionally, thus allowing regular lactation and breastfeeding in young women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Management of nipple adenomas during pregnancy: a case report

et al. 2023

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Erythematous Papule on the Breast of a Middle-Aged Woman: Answer

Humeda,

Holland,

Haeberle

et al. 2024

The American Journal of Dermatopathology

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Nipple adenoma detected by multimodal ultrasound: a case report and literature review

Lu,

Zhang,

et al. 2024

Front. Oncol.

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Nipple adenoma (NA) is a rare benign lesion of the lactiferous ducts, often mistaken for malignancy due to its diverse clinical and imaging presentations. We report the case of a 34-year-old female presenting with persistent bloody discharge and nipple erosion, for which multimodal ultrasound evaluation was pivotal in the differential diagnosis. Ultrasonography revealed a hypoechoic, well-defined nodule in the left nipple, with significant blood flow and a fast-in-fast-out contrast enhancement pattern, indicative of NA. Despite the presentation mimicking malignant processes, the benign nature of the lesion was confirmed postoperatively via histology and immunohistochemistry. This case underscores the value of a comprehensive ultrasound approach in diagnosing NA, emphasizing its ability to distinguish it from malignant lesions, and thus infer an appropriate treatment course. Maintaining a high index of suspicion coupled with tailored ultrasound techniques is recommended for accurate NA diagnosis, which remains a challenging yet critical task to avoid unnecessary aggressive interventions.

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Nipple Adenoma: A Benign Disease With a Suspicious Presentation

Cited by 5 publications

References 4 publications

Management of nipple adenomas during pregnancy: a case report

Management of nipple adenomas during pregnancy: a case report

Erythematous Papule on the Breast of a Middle-Aged Woman: Answer

Nipple adenoma detected by multimodal ultrasound: a case report and literature review

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