Nipple-Sparing Mastectomy: Are We Providing Proper Prophylactic Antibiotic Coverage?

ElSherif, Ayat; Cocco, Daniela; Armanyous, Sherif; Cummins, Andi; Shaffer, Kristina; Duraes, Eliana; Bernard, Steven; Djohan, Risal; Schwarz, Graham S.; Tu, Chao; Valente, Stephanie A.

doi:10.1245/s10434-021-10449-5

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…Following an assessment of 675 relevant papers, 18 papers that were released between 2009 and 2023 were included in the meta‐analysis since they matched the inclusion criteria 11,12,24–39 . Table 2 summarises the findings of these investigations.…”

Section: Resultsmentioning

confidence: 99%

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Effect of prolonged antibiotic prophylaxis on the occurrence of surgical site wound infection after instant breast reconstruction: A meta‐analysis

Jin,

2023

International Wound Journal

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The purpose of the meta‐analysis was to evaluate and compare the effects of prolonged antibiotic prophylaxis on the occurrence of surgical site wound infection after instant breast reconstruction. The results of this meta‐analysis were analysed, and the odds ratio (OR) and mean difference with 95% confidence intervals (CIs) were calculated using dichotomous or contentious random‐ or fixed‐effect models. For the current meta‐analysis, 18 examinations spanning from 2009 to 2023 were included, encompassing 19 301 females with instant breast reconstruction. Systemic antibiotic prophylaxis had a significantly lower surgical site wound infection rate (OR, 0.85; 95% CI, 0.75–0.98, p = 0.02) compared with the standard of care after instant breast reconstruction in females. Topical antibiotic prophylaxis had a significantly lower surgical site wound infection rate (OR, 0.26; 95% CI, 0.13–0.52, p < 0.001) compared with the standard of care after instant breast reconstruction in females. The examined data revealed that systemic and topical antibiotic prophylaxis had a significantly lower surgical site wound infection rate compared with the standard of care after instant breast reconstruction in females. However, given that several examinations had a small sample size, consideration should be given to their values.

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Section: Resultsmentioning

confidence: 99%

“…The sample size was 37-7398 people. 11,12,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] The examined data revealed that systemic antibiotic prophylaxis had a T A B L E 1 Database search strategy for inclusion of examinations.…”

Section: Discussionmentioning

confidence: 99%

Effect of prolonged antibiotic prophylaxis on the occurrence of surgical site wound infection after instant breast reconstruction: A meta‐analysis

Jin,

2023

International Wound Journal

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“…This may be related to poor blood supply in the breast skin following breast cancer surgery, and radiotherapy reduces the body's anti‐infection capacity 7 . Moreover, with the rise in popularity of nipple‐sparing mastectomy, the lactation duct transected at the base of the nipple has become an open channel for pathogen entry and a potential infection focal site, which increased the risk of infection 16 . In this study, a total of 10 individuals were infected with S. aureus following breast reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of pathogen distribution and antimicrobial resistance in breast plastic surgery infection

Jiang

et al. 2023

J of Cosmetic Dermatology

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BackgroundThe demand for mammaplasty has increased in recent years, and infection remains one of the common and serious post‐operative complications. In this study, we analyzed the pathogen distribution and antibiotic susceptibility of breast plastic surgery infections, and compared the differences in pathogenic species between surgical procedures.MethodsThe number of each species was counted in the microbial samples of breast plastic surgery infections in Plastic Surgery Hospital of Chinese Academy of Medical Sciences from January 2011 to December 2021. The in vitro antibiotic sensitivity testing data were analyzed using WHONET 5.6 software. The surgical techniques, the period of infection, and other details were gathered in accordance with the clinical data.ResultsThere were a total of 42 cases included, and 43 different types of pathogenic bacteria, mostly gram‐positive bacteria, were found. CoNS (13/43) and Staphylococcus aureus (22/43) made up the majority. The most prevalent of the five Gram‐negative bacteria was Pseudomonas aeruginosa. Results of drug sensitivity tests indicate that S. aureus is highly sensitive to vancomycin, cotrimoxazole, and linezolid, whereas CoNS is highly sensitive to vancomycin, linezolid, and chloramphenicol. Both of these bacteria show high resistance to erythromycin and penicillin. Breast augmentation, breast reconstruction, and breast reduction surgery were the most frequently associated breast surgery procedures in this study with infections, with the highest number of infections occurring following breast augmentation with fat grafting, breast reduction surgery, and breast reconstruction with autologous tissue. Various breast plastic surgery procedures have different common pathogens of infection, but the most prevalent are CoNS and S. aureus. Additionally, the majority of the infections in this study were in the early stages.ConclusionsGram‐positive bacteria were the predominant cause of breast plastic surgery infections, and the types of infection strains, the period of infection onset, and the antibiotic susceptibility of prevalent strains varied between breast plastic procedures.

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“…5 The annual Outstanding Scientific Presentation Award for the best abstract presented by a resident, medical trainee, or fellow went to Dr. Ayat ElSherif from the Cleveland Clinic for her work on antibiotic prophylaxis for nipple-sparing mastectomy with immediate breast reconstruction. 6 The Scientific Impact Award went to Dr. David Lim from the Toronto Women's College Research Institute on the relationship between the breast tumor pathologic response to neoadjuvant systemic therapy and axillary nodal response. 7 Much gratitude is given to the 31 members of the Publication Committee for careful blinded review (to both authors and institutional source) of 220 research abstracts for selection of the top studies for oral scientific, ''quickshot,'' and poster-discussion presentations, and for the final review and selection of the highest impact publications for this issue of Annals of Surgical Oncology.Just some of the highlighted research studies published in this issue of Annals of Surgical Oncology include important work regarding post-operative pain management, 8 understanding current axillary management, 9,10 potential new methods for decreasing surgery for margin control, 11 inflammatory breast cancer, 12 cryoablation without surgery for early invasive breast cancer, 13 and how the COVID-19 pandemic has altered practice among our society members.…”

Section: Oral and Scientific Session Highlightsmentioning

confidence: 99%

22nd Annual Virtual Meeting of the American Society of Breast Surgeons: Science, Innovation, and Practice Changes

Calvillo¹,

Blair

Kuerer

2021

Ann Surg Oncol

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Nipple-Sparing Mastectomy: Are We Providing Proper Prophylactic Antibiotic Coverage?

Cited by 6 publications

References 31 publications

Effect of prolonged antibiotic prophylaxis on the occurrence of surgical site wound infection after instant breast reconstruction: A meta‐analysis

Effect of prolonged antibiotic prophylaxis on the occurrence of surgical site wound infection after instant breast reconstruction: A meta‐analysis

Evaluation of pathogen distribution and antimicrobial resistance in breast plastic surgery infection

22nd Annual Virtual Meeting of the American Society of Breast Surgeons: Science, Innovation, and Practice Changes

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