Nippostrongylus brasiliensis and Nematospirojdes dubius: Cross immunity studies using Millipore® diffusion chambers

Hitcho, Paul J.; Thorson, Ralph E.

doi:10.1016/0020-7519(74)90090-3

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…The former of these suggestions is probably more realistic because the level of homologous immunity passively transferred with serum was commensurate with the levels of immunity induced actively by infection in the serum donors. In contrast to the results of Hitcho and Thorson (1974) and the results presented here. Day et al (1979) recorded high specificity of allergens in adult excretory/secretory/ metabolic products for these two species of parasite as determined by absence of heterologous allergen-reagin cross-reactions in vitro.…”

Section: Discussioncontrasting

confidence: 99%

“…Protective cross-immunity between A', brasiliensis and N. dubius infections in rats and mice can be induced following immunization using larvae of the heterologous species implanted into the peritoneum of the host in semi-permeable capsules (Hitcho and Thorson, 1974). We have also shown serological cross-reactions between antigens from these parasite species.…”

Section: Introductionmentioning

confidence: 70%

“…Hitcho and Thorson (1974) showed that active cross-immunization with N. dubius larvae in rats and A^. brasiliensis larvae in mice, induced with parasites implanted in diffusion chambers, provided 40 to 60% protection in rats to N. brasiliensis and about 33% protection in mice against N. dubius.…”

Section: Discussionmentioning

confidence: 99%

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SPECIFICITY OF PASSIVE SERUM PROTECTION AGAINST NIPPOSTRONGYLUS BRASILIENSIS AND NEMATOSPIROIDES DUBIUS IN MICE

Brindley

Dobson

1983

Aust J Exp Biol Med

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Summary Fewer and smaller worms were recovered from, and significantly fewer parasite eggs were voided by, mice injected with mouse antiserum raised against Nippostrongylus brasiliensis or Nematospiroides dubius after infection with the homologous nematode species compared with the control mice. The passive transfer of protective immunity was specific for the species which induced the antibody response in the donor mice. Passively immunized mice infected with the heterologous nematode species harboured the same number of worms, with the same epg output, as parasites in the control mice, but were stunted. Serological cross‐reactions were observed between the two donor antiserum pools and N. dubius and N. brasiliensis antigens.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 70%

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SPECIFICITY OF PASSIVE SERUM PROTECTION AGAINST NIPPOSTRONGYLUS BRASILIENSIS AND NEMATOSPIROIDES DUBIUS IN MICE

Brindley

Dobson

1983

Aust J Exp Biol Med

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Heterologous antagonistic and synergistic interactions between helminths and between helminths and protozoans in concurrent experimental infection of mammalian hosts

et al. 1987

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Experimental concurrent infection with two or more parasite species in mammalian host models may result in heterologous antagonistic and synergistic interactions ranging in magnitude from reduced/enhanced growth and fecundity to blockage/enhancement of establishment/expulsion. With some exceptions only, there is a reasonable correlation between the levels of interaction monitored by parasitological and by clinico-pathological parameters. Heterologous antagonistic interactions mediated by functional and specific immunological cross-reactivity occur between closely related parasite species exhibiting a marked immunobiological similarity. In contrast, antagonistic interactions between antigenetically more remote species of helminths, protozoan-induced resistance to helminth infection and helminth-induced suppression of concurrent protozoan infection generally appear mediated by immunologically non-specific factors like macrophage activation and inflammatory reactions. Synergistic heterologous interactions between helminths, helminth-induced enhancement of concurrent protozoan infection and interference with the development and maintenance of resistance to helminth infection in response to concurrent protozoan infection are generally thought to be mediated by non-specific parasite-induced immunosuppression. Concurrent experimental infection is very complex. There are problems and limitations in extrapolating from experimental studies on concurrent infection in laboratory animals to natural polyparasitism. This fact, coupled with the complex influence of ecological factors on the pattern and frequency of concurrent natural infection means that major consequences of natural concurrent parasite infection have not been definitively demonstrated. Appropriately planned and controlled field studies and further laboratory experiments on primate and domestic animal models are imperative for elucidation of the importance of heterologous interactions in concurrent parasite infection for the disease pattern in man and domestic stock. Experimental studies hitherto conducted on concurrent parasite infection pointing to natural heterologous interactions may be a valuable starting point for further studies.

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The reduction of worm burden and egg production inMicrophallus pygmaeus (Levinsen 1881) (Digenea: Microphallidae) induced by a concurrent infection withHymenolepis nana (Cestoda: Cyclophyllidea)

Molan

James

1984

Z. Parasitenkd.

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Nippostrongylus brasiliensis and Nematospirojdes dubius: Cross immunity studies using Millipore® diffusion chambers

Cited by 6 publications

References 4 publications

SPECIFICITY OF PASSIVE SERUM PROTECTION AGAINST NIPPOSTRONGYLUS BRASILIENSIS AND NEMATOSPIROIDES DUBIUS IN MICE

SPECIFICITY OF PASSIVE SERUM PROTECTION AGAINST NIPPOSTRONGYLUS BRASILIENSIS AND NEMATOSPIROIDES DUBIUS IN MICE

Heterologous antagonistic and synergistic interactions between helminths and between helminths and protozoans in concurrent experimental infection of mammalian hosts

The reduction of worm burden and egg production inMicrophallus pygmaeus (Levinsen 1881) (Digenea: Microphallidae) induced by a concurrent infection withHymenolepis nana (Cestoda: Cyclophyllidea)

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