NIR‐Activatable Heterostructured Nanoadjuvant CoP/NiCoP Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy and Photoimmunotherapy

Abstract

Near‐infrared (NIR) laser‐induced photoimmunotherapy has aroused great interest due to its intrinsic non‐invasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation severely limits its clinical outcomes. Although several metabolic interventions have been devoted to ameliorate immunosuppression, intracellular residual LA still remains a potential energy source for oncocyte proliferation. Herein, we construct an immunomodulatory nanoadjuvant based on a yolk‐shell CoP/NiCoP (CNCP) heterostructure loaded with the monocarboxylate transporter 4 (MCT4) inhibitor fluvastatin sodium (Flu) to concurrently relieve immunosuppression and elicit robust antitumor immunity. Under NIR irradiation, CNCP heterojunctions exhibit superior photothermal performance and photocatalytic production of reactive oxygen species (ROS) and hydrogen. The continuous heat then facilitates Flu release to restrain LA exudation from tumor cells, whereas cumulative LA can be depleted as a hole scavenger to improve photocatalytic efficiency. Subsequently, potentiated photocatalytic therapy (PCT) can not only initiate systematic immunoreaction, but also provoke severe mitochondrial dysfunction and disrupt the energy supply for heat shock protein (HSP) synthesis, in turn realizing mild photothermal therapy (PTT). Consequently, LA metabolic remodeling endows an intensive cascade treatment with an optimal safety profile to effectually suppress tumor proliferation and metastasis, which offers a new paradigm for the development of metabolism‐regulated immunotherapy.This article is protected by copyright. All rights reserved

Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen Therapy for Diabetic Wound Dressing

“…H 2 is reported to be an effective antioxidant. 41 TMB and DPPH assays were used to estimate the antioxidant potential of the synthesized hydrogels. The total antioxidant capacity of HAP-Chl was first studied with TMB colorimetric analysis.…”

“…H 2 is reported to be an effective antioxidant . TMB and DPPH assays were used to estimate the antioxidant potential of the synthesized hydrogels.…”

Biodegradable Bismuth Nanostructures as a Ferroptosis Inducer for Phototherapy of Breast Cancer

“…Their degradability is crucial to mitigate the potential long-term toxicity of nanomaterials in living organisms. 35 Given the acidic nature of the tumor microenvironment and the presence of excess H 2 O 2 and GSH, we investigated the degradation behavior of BBSP in aqueous solutions with varying conditions, including pH 7.4/H 2 O 2 , 7.4/GSH, 7.4/GSH/H 2 O 2 , and 5.5/GSH/H 2 O 2 . Surprisingly, as depicted in Figure 3a, TEM images revealed that the particle size of BBSP gradually decreased over time at pH 7.4/GSH/ H 2 O 2 .…”