NIR and Reduction Dual-Sensitive Polymeric Prodrug Nanoparticles for Bioimaging and Combined Chemo-Phototherapy

Abstract

The combination of chemotherapy, photothermal therapy (PTT) and photodynamic therapy (PDT) based on a single nanosystem is highly desirable for cancer treatment. In this study, we developed a versatile Pt(IV) prodrug-based nanodrug, PVPt@Cy NPs, to realize synchronous chemotherapy, PDT and PTT and integrate cancer treatment with bioimaging. To construct PVPt@Cy NPs, the amphiphilic Pt(IV)-based polymeric prodrug PVPt was synthesized by a facile one-pot coupling reaction, and then it was used to encapsulate an optotheranostic agent (HOCyOH, Cy) via hydrophobic interaction-induced self-assembly. These NPs would disaggregate under acidic, reductive conditions and NIR irradiation, which are accompanied by photothermal conversion and reactive oxygen species (ROS) generation. Moreover, the PVPt@Cy NPs exhibited an enhanced in vitro anticancer efficiency with 808-nm light irradiation. Furthermore, the PVPt@Cy NPs showed strong NIR fluorescence and photothermal imaging in H22 tumor-bearing mice, allowing the detection of the tumor site and monitoring of the drug biodistribution. Therefore, PVPt@Cy NPs displayed an enormous potential in combined chemo-phototherapy.

Tailoring dual drug-backboned polyurethane prodrug nanoparticles as all-in-one nanomedicine for precise multimodal imaging-guided PTT-chemotherapy

“…Platinum(IV) prodrug (cis, cis, trans-[Pt(NH 3 ) 2 Cl 2 (OH) 2 ], DHP), free HOCyOH and isocyanate functionalized poly(ethylene glycol) monomethyl ether (mPEG 5k -NCO) were initially prepared according to the methods presented in our previous works. 52,53 PUCPt was synthesized through the condensation polymerization method. In detail, a mixture of DHP (200 mg, 0.6 mmol) and 10 mL dried DMSO was dropwise added into LDI (226 mg, 1.0 mmol) at 0 1C under N 2 atmosphere.…”

Improving photophysical properties and hydrophily of conjugated polymers simultaneously by side-chain modification for near-infrared cell imaging

“…19,20 A variety of conjugated polymers were developed for NIR uorescence imaging and PTT. 21,22 Although signi cant progress has been made, the means of regulating photophysical properties are limited and mainly focus on modulating the D-A effect, 23 adjusting the length of π conjugation 24 and controlling intermolecular π-π stacking interactions. 25 In addition, these conjugated polymers often require encapsulation or the introduction of additional hydrophilic groups to form water-dispersible nanoparticles for probes.…”

Azide-Locked Prodrug Co-Assembly into Nanoparticles with Indocyanine Green for Chemophotothermal Therapy

“…Presently, therapeutic strategies such as chemotherapy, surgery, and immunotherapy play an important role in clinical treatment of tumors. − However, the low delivery efficiency and weak sensitivity to the tumor microenvironment (TME) limit the treatment outcomes. Thus, it is necessary to develop an advanced delivery technology to promote the development of tumor therapy. − Nanomedicine-based delivery technology can effectively improve drug distribution through selective response to TME. − To investigate this, various matrix materials such as liposomes, − inorganic nanoparticles, − polymeric prodrugs, − small molecular drugs, − and organic/inorganic hybrid matter − have been used for designing the drug carrier. Although tremendous advances have been made, some major difficulties such as complex synthesis and high carrier proportion still exist.…”