NIR assignment of isopsoralen by 2D-COS technology and model application in Yunkang Oral Liquid

Pei, Yanling; Wu, Zhisheng; Shi, Xinyuan; Pan, Xun; Peng, Yanfang; Qiao, Yanjiang

doi:10.1142/s1793545815500236

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Our previous researches also illustrated that spectral assignment was of great significance for NIR modeling. The NIR spectral assignments of Yunkang Oral Liquid 23 and Lonicera japonica have been performed and made the models more accurate 24 .…”

Section: Introductionmentioning

confidence: 99%

Systematic discovery about NIR spectral assignment from chemical structural property to natural chemical compounds

Peng

Pei

et al. 2019

Sci Rep

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Spectra-structure interrelationship is still the weakness of NIR spectral assignment. In this paper, a comprehensive investigation from chemical structural property to natural chemical compounds was carried out for NIR spectral assignment. Surprisingly, we discovered that NIR absorption frequency of the skeleton structure with sp 2 hybridization is higher than one with sp 3 hybridization. Specifically, substituent was another vital factor to be explored, the first theory discovery demonstrated that the absorption intensity of methyl substituted benzene at 2330 nm has a linear relationship with the number of substituted methyl C-H. The greater the number of electrons given to the substituents, the larger the displacement distance of absorption bands is. In addition, the steric hindrance caused by the substituent could regularly reduce the intensity of NIR absorption bands. Furthermore, the characteristic bands and group attribution of 29 natural chemical compounds from 4 types have been systematic assigned. These meaningful discoveries provide guidance for NIR spectral assignment from chemical structural property to natural chemical compounds.

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Section: Introductionmentioning

confidence: 99%

Systematic discovery about NIR spectral assignment from chemical structural property to natural chemical compounds

Peng

Pei

et al. 2019

Sci Rep

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“…NIR characteristic bands of more than 30 natural chemical compounds were assigned, such as artemisinin, schisandrin A, isopsoralen, magnolol, etc. 19 Furthermore, the characteristic bands were used to establish the NIR quantitative model for quality control of Yunkang Oral Liquid 20 and Huoxiangzhengqi Oral Liquid. 21 System modeling algorithm for process quality control of CMM manufacturing…”

Section: Resultsmentioning

confidence: 99%

Process quality control of the manufacturing of Chinese Materia Medica by process analysis technology

Qiao

2019

NIR news

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Process quality control is essential for the manufacturing of Chinese Materia Medica. Non-destructive monitoring is still a challenge for the quality control of Chinese Materia Medica manufacturing. As the commonly used non-destructive process analysis technology, near infrared spectroscopy, near infrared chemical imaging, and laser-induced breakdown spectroscopy have been applied to the quality control of Chinese Materia Medica manufacturing. The characteristic near infrared bands of 29 natural chemical components have been assigned. Ten spectral pre-processing methods and five variable selection methods have been optimized, respectively. Given the interrelationship among modeling parameters, a system modeling concept was put forward to establish a global model. Accuracy Profile was further proposed as the validation method of models. In addition, the homogeneity of chlorpheniramine maleate tablets from six brands was successfully visualized by near infrared-chemical imaging. As and Hg variation in An-Gong-Niu-Huang Wan have been rapidly monitored by laser-induced breakdown spectroscopy. A systematic modeling method (model establishment, evaluation, and validation) and the non-destructive technology of homogeneity visualization and toxic element detection have been developed for quality control of Chinese Materia Medica manufacturing, which is shown in Figure 1 of the article. These achievements have greatly promoted the research and application of process analysis technology in Chinese Materia Medica manufacturing, laying a solid foundation for the development of intelligent Chinese pharmaceutical industry.

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“…Oxygen-containing groups above [26], especially the strong polar groups such as-OH, are abundant on the surface of the bioflocculant, which makes the materials water soluble. Shock and displacement of the absorption peak showed that the dispersion is good and the polarity is enhanced, and the adsorption of chromium by bioflocculant is promoted [27]. The migration and change of the infrared peak show that the existence of flocculant may destroy the stability of the colloid, which may be caused by adsorption, but it may also be caused by the role of net catching.…”

Section: Effects Of Flocculant Dosage Temperature Ph and Flocculatmentioning

confidence: 99%

Colloidal Influence Factor of Bioflocculant in Coagulation of Chromium and Nitrobenzene

Chen

et al. 2020

Journal of Sensors

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The aim of this study is to investigate the flocculation capacity of activated sludge flocculant in chromium ion and nitrobenzene solutions. Besides comparing with activated carbon, we changed some potential factors which may influence the flocculation, such as solution pH value, reaction time, flocculant dosage, and solution initial concentration, and tested the flocculation capacity of this bioflocculant for both chromium and nitrobenzene. In addition, the flocculation of activated sludge after acidic or alkali modification for double solutions was also estimated. Compared with activated carbon, the activated sludge flocculant showed a good flocculation capacity for nitrobenzene, but poor flocculation for chromium following the initial concentration increase. The flocculation for nitrobenzene or chromium increased at initial stage and decreased gradually following the primary dosage of flocculant increase. The flocculation for nitrobenzene increased at the primary stage and decreased after peak, while the flocculation for chromium increased following the pH increase of both solutions. Although the flocculation for nitrobenzene decreased, the flocculation for chromium increased obviously, when we prolonged the reaction time. The flocculant showed a gradual increasing trend in double kinds of solution when they were heating. The flocculation for both nitrobenzene and chromium decreased after acid modification of activated sludge flocculant, while the flocculation increased after basic modification. The present research provided further theoretical basis of the biosorption of heavy metal waste water and nitrobenzene organic toxicants.

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NIR assignment of isopsoralen by 2D-COS technology and model application in Yunkang Oral Liquid

Cited by 5 publications

References 18 publications

Systematic discovery about NIR spectral assignment from chemical structural property to natural chemical compounds

Systematic discovery about NIR spectral assignment from chemical structural property to natural chemical compounds

Process quality control of the manufacturing of Chinese Materia Medica by process analysis technology

Colloidal Influence Factor of Bioflocculant in Coagulation of Chromium and Nitrobenzene

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