“…For example, chemotherapy, which is one of the most common clinical methods for breast cancer therapy, is non-specific and always accompanied with serious side effects because of lacking effective carriers ( Tao et al, 2013 , 2015a ; Shi J. et al, 2017 ; Zeng et al, 2017 ). Nano-biotechnology has shown promising prospects for changing the landscape of pharmaceutical and biomedical industries fundamentally ( Shi et al, 2010 ; Tao et al, 2015b , 2017b , d ; He et al, 2016 ; Wang et al, 2016 , 2017 ; Hofmann et al, 2017 ; Niu et al, 2017 ; Qi et al, 2017 ; Shi B. et al, 2017 ; Shi J. et al, 2017 ; Xu et al, 2017a , b ). The key to solve the side effects caused by cytotoxic anticancer drugs is to increase the local effective drug concentrations in the tumor sites, which could be addressed by employing polymeric nanoparticles (NPs) as highly promising target drug delivery systems ( Kamaly et al, 2016 ; Kakkar et al, 2017 ; Nie et al, 2017 ; Tao et al, 2017c ; Xu et al, 2017 ).…”