2017
DOI: 10.1039/c7nr02363d
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NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis

Abstract: Motivated by the goal of developing a fully biodegradable optical contrast agent with translational clinical potential, a nanoparticle delivery vehicle was generated from the self-assembly of poly(ethylene-glycol)-block-poly(trimethylene carbonate-co-caprolactone) (PEG-b-TCL) copolymers. Cryogenic transmission electron microscopy verified that PEG-b-TCL-based micelles were formed at low solution temperatures (~ 38 °C). Detailed spectroscopic experiments validated facile loading of large quantities of the high … Show more

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Cited by 15 publications
(9 citation statements)
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“…The paclitaxel formulation, Genexol-PM, based on PEG-PLA NPs was approved by South Korea in 2007 for the treatment of breast cancer, lung cancer, and ovarian cancer, and it is currently under clinical development in the United States ( Lee et al, 2008 ; Luo et al, 2012 ). Several other nanomedicine formulations based on PEG-PLA NPs are also in clinical trials ( He et al, 2016 ; Hofmann et al, 2017 ; Niu et al, 2017 ; Tao et al, 2017 ). Therefore, PEG-PLA would be an ideal material for the encapsulation of the lipophilic drugs such as ELTN and FDTN, which would endow better translational potentials.…”
Section: Introductionmentioning
confidence: 99%
“…The paclitaxel formulation, Genexol-PM, based on PEG-PLA NPs was approved by South Korea in 2007 for the treatment of breast cancer, lung cancer, and ovarian cancer, and it is currently under clinical development in the United States ( Lee et al, 2008 ; Luo et al, 2012 ). Several other nanomedicine formulations based on PEG-PLA NPs are also in clinical trials ( He et al, 2016 ; Hofmann et al, 2017 ; Niu et al, 2017 ; Tao et al, 2017 ). Therefore, PEG-PLA would be an ideal material for the encapsulation of the lipophilic drugs such as ELTN and FDTN, which would endow better translational potentials.…”
Section: Introductionmentioning
confidence: 99%
“…For example, chemotherapy, which is one of the most common clinical methods for breast cancer therapy, is non-specific and always accompanied with serious side effects because of lacking effective carriers ( Tao et al, 2013 , 2015a ; Shi J. et al, 2017 ; Zeng et al, 2017 ). Nano-biotechnology has shown promising prospects for changing the landscape of pharmaceutical and biomedical industries fundamentally ( Shi et al, 2010 ; Tao et al, 2015b , 2017b , d ; He et al, 2016 ; Wang et al, 2016 , 2017 ; Hofmann et al, 2017 ; Niu et al, 2017 ; Qi et al, 2017 ; Shi B. et al, 2017 ; Shi J. et al, 2017 ; Xu et al, 2017a , b ). The key to solve the side effects caused by cytotoxic anticancer drugs is to increase the local effective drug concentrations in the tumor sites, which could be addressed by employing polymeric nanoparticles (NPs) as highly promising target drug delivery systems ( Kamaly et al, 2016 ; Kakkar et al, 2017 ; Nie et al, 2017 ; Tao et al, 2017c ; Xu et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%
“…These impressive PZn n photophysical properties have been exploited in a wide range of uorescence imaging applications. [54][55][56][57][58][59][60][61] The photophysical properties of PZn n chromophores may be extensively modulated via incorporation of proquinoidal units into these emblematic conjugated arrays. For example, proquinoidal spacer (Sp) moieties such as 4,7-diethynylbenzo [c] [1,2,5]thiadiazole (E-BTD-E), 6,13-diethynylpentacene (E-PC-E), 4,9-diethynyl-6,7-dimethyl [1,2,5]thiadiazolo [3,4-g]quinoxaline (E-TDQ-E), and 4,8-diethynylbenzo[1,2-c:4,5-c 0 ] bis( [1,2,5]thiadiazole) (E-BBTD-E) that link bis[(porphinato) zinc] units can be utilized to modulate the relative degrees of quinoidal character that characterize the ground and electronically excited singlet states in these highly conjugated supermolecules.…”
Section: Introductionmentioning
confidence: 99%
“…Steady-state absorption and emission spectroscopy of BTD-PZn n -BTD, PZn-(BTD-PZn) n , and PZn 2 -(BTD-PZn 2 ) n chromophores Steady-state electronic absorption and uorescence spectra recorded for reference PZn n chromophores (PZn 2 , PZn 3 , and PZn 5 ; Fig. 1A), 17,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][54][55][56]58,59,61,63,65 as well as PZn-(BTD-PZn) n [PZn-BTD-PZn, 62 PZn-(BTD-PZn) 2 , and PZn-(BTD-PZn) 4 ; Fig. 1B], PZn 2 -(BTD-PZn 2 ) n [PZn 2 -BTD-PZn 2 and PZn 2 -(BTD-PZn 2 ) 2 ; Fig.…”
Section: Introductionmentioning
confidence: 99%