“…The photothermal nanoagents can absorb the NIR and convert the optical energy into heat, which then initiates the cell membrane breakage and protein denaturation in bacteria, finally leading to their thermal ablation [102][103][104]. Based on this, NIR-responsive nanozymes, such as Au nanoplates [26], Au@Pt nanodots [32], Au NRs/CeO 2 hybrid [91], rough carbon/Fe 3 O 4 nanohybrids [102], cationic chitosan@RuO 2 hybrid [105], MoS 2 nanozymes [43,82,106], N-doped carbon nanozyme [55], PEG@Zr-Fc MOF hydrogel [107], and Fe-and Cu-N-C SAzymes [61,63,64], have been developed. Under the NIR laser irradiation, these NIR-active nanozymes can not only produce local photothermal effect, but more importantly the elevated temperature certainly accelerates catalytic reaction rate, thereby realizing the enhanced synergic CDT and PTT for effectively treating drug-resistant bacterial infections.…”