NIR light-triggered shrinkable thermoresponsive PNVCL nanoshells for cancer theranostics

Chauhan, Deepak S.; Indulekha, S.; Gottipalli, Rupesh; Reddy, B. Pradeep K.; Chikate, Tanmayee; Gupta, Ramkrishn; Jahagirdar, Dushyant; Prasad, Rajendra; De, Abhijit; Srivastava, Rohit

doi:10.1039/c7ra07485a

Cited by 23 publications

(35 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PNVCL is a thermoresponsive polymer which exhibits LCST that has been applied in biomedical and environmental applications, in cosmetics and as an anticlogging agent in pipelines [ 3 , 4 ]. PNVCL is usually described as a biocompatible alternative to poly-N-isopropylamide (PNIPAM) [ 3 , 4 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ] as both polymers can exhibit LCST behavior close to the physiological temperature. According to this misconception, PNVCL has been often described as a polymer with a well-defined LCST at 32 °C [ 7 , 8 , 9 , 16 , 17 , 18 , 19 , 20 , 21 ], even though the LCST has been observed in broad range of temperature between 25 and 50 °C [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…PNVCL is usually described as a biocompatible alternative to poly-N-isopropylamide (PNIPAM) [ 3 , 4 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ] as both polymers can exhibit LCST behavior close to the physiological temperature. According to this misconception, PNVCL has been often described as a polymer with a well-defined LCST at 32 °C [ 7 , 8 , 9 , 16 , 17 , 18 , 19 , 20 , 21 ], even though the LCST has been observed in broad range of temperature between 25 and 50 °C [ 3 , 4 ]. As a matter of fact, PNVCL and PNIPAM exhibit a complete opposite miscibility behavior [ 3 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of Thermoresponsive Poly-N-Vinylcaprolactam Polymers for Biological Applications

Marsili

Eisele

et al. 2021

Polymers

View full text Add to dashboard Cite

Poly-N-Vinylcaprolactam (PNVCL) is a thermoresponsive polymer that exhibits lower critical solution temperature (LCST) between 25 and 50 °C. Due to its alleged biocompatibility, this polymer is becoming popular for biomedical and environmental applications. PNVCL with carboxyl terminations has been widely used for the preparation of thermoresponsive copolymers, micro- and nanogels for drug delivery and oncological therapies. However, the fabrication of such specific targeting devices needs standardized and reproducible preparation methods. This requires a deep understanding of how the miscibility behavior of the polymer is affected by its structural properties and the solution environment. In this work, PNVCL-COOH polymers were prepared via free radical polymerization (FRP) in order to exhibit LCST between 33 and 42 °C. The structural properties were investigated with NMR, FT-IR and conductimetric titration and the LCST was calculated via UV-VIS and DLS. The LCST is influenced by the molecular mass, as shown by both DLS and viscosimetric values. Finally, the behavior of the polymer was described as function of its concentration and in presence of different biologically relevant environments, such as aqueous buffers, NaCl solutions and human plasma.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Thermoresponsive Poly-N-Vinylcaprolactam Polymers for Biological Applications

Marsili

Eisele

et al. 2021

Polymers

View full text Add to dashboard Cite

show abstract

“…142,143 Therefore, one of the strategies of cancer treatment is photodynamic therapy connected with simultaneous chemotherapy, called chemo-photothermal therapy. [144][145][146] Another solution is the use of ionizable functional groups under the influence of radiation. Ionization caused by radiation leads to increasing the osmotic pressure inside the matrix and the hydrogel swell, similarly as in the case of systems sensitive to pH changes.…”

Section: Photosensitive Hydrogelsmentioning

confidence: 99%

<p>Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems</p>

Kasiński¹,

Zielińska–Pisklak²,

Olędzka³

et al. 2020

IJN

136

107

View full text Add to dashboard Cite

Among modern drug formulations, stimuli-responsive hydrogels also called "smart hydrogels" deserve a special attention. The basic feature of this system is the ability to change their mechanical properties, swelling ability, hydrophilicity, bioactive molecules permeability, etc., influenced by various stimuli, such as temperature, pH, electromagnetic radiation, magnetic field and biological factors. Therefore, stimuli-responsive matrices can be potentially used in tissue engineering, cell cultures and technology of innovative drug delivery systems (DDSs), releasing the active substances under the control of internal or external stimuli. Moreover, smart hydrogels can be used as injectable DDSs, due to gel-sol transition connected with in situ cross-linking process. Innovative smart hydrogel DDSs can be utilized as matrices for targeted therapy, which enhances the effectiveness of tumor chemotherapy and subsequently limits systemic toxicity. External stimulus sensitivity allows remote control over the drug release profile and gel formation. On the other hand, internal factors provide drg accumulation in tumor tissue and reduce the concentration of active drug form in healthy tissue. In this report, we summarise the basic knowledge and chemical strategies for the synthetic smart hydrogel DDSs applied in antitumor therapy.

show abstract

“…The lower critical solubility temperature (LCST) thermoresponsive polymers such as poly (N-isopropyl acrylamide) (PNIPAAm), and poly (N-vinyl caprolactam) (PNVCL) have been developed for DDSs of anticancer drugs [27][28][29][30]. Among LCST polymers, PNVCL as a hydrophilic biocompatible temperaturesensitive polymer is used for various biomedical applications [30][31][32][33][34]. Furthermore, the biocompatibility of PNVCL is higher than PNIPAAm, due to the hydrolysis of acrylamide groups of PNIPAAm and the production of small compounds which is not suitable for biomedical applications [35].…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin Loaded-UiO-66-NH2 Coated With Poly(N-Vinylcaprolactam) For Controlled Release of Doxorubicin Against A549 Lung Cancer

Rakhshani

Nemati

Ramazani

et al. 2021

Preprint

View full text Add to dashboard Cite

The use of nano metal-organic frameworks (NMOFs) has been developed for drug delivery systems due to their high porosity and large specific surface area. In this work, UiO-66-NH2 NMOFs were synthesized via the microwave heating method and doxorubicin (DOX) molecules were incorporated into the UiO-66-NH2 NMOFs. Then, poly(N-Vinylcaprolactam) (PNVCL) synthesized by the free radical polymerization was coated on the NMOFs surface to fabricate the pH/temperature-sensitive carrier against A549 lung cancer cells death in vitro. The synthesized nanocarriers were characterized using FTIR, XRD, SEM, FESEM, TGA, and BET analysis. The average particle sizes of UiO-66-NH2 MOF and PNVCL coated-UiO-66-NH2 /DOX MOF nanoparticles were found to be 175 nm and 235 nm, respectively. TGA analysis showed that the PNVCL percentage coated on the UiO-66-NH2 NMOFs surface was about 17.5 %, and 27.3% for NMOFs incubated in 1% and 2% PNVCL solutions, respectively. The BET surface area of UiO-66-NH2 NMOFs, UiO-66-NH2 NMOFs/DOX 100 μg mL-1, and PNVCL 1% coated-NMOFs/DOX was found to be 1052, 121, and 87 m2g-1, respectively. The DOX release data of UiO-66-NH2 and PNVCL coated- UiO-66-NH2/DOX were evaluated under pH values of 5.5, 7.4, and temperatures of 25 °C, 37°C. The anticancer activity of synthesized NMOFs was investigated against lung cancer cells (A549) in vitro. The maximum cytotoxicity of A549 cancer cells was found to be 76% using PNVCL 1% coated-UiO-66-NH2/DOX 100 μg mL-1 NMOFs.

show abstract

NIR light-triggered shrinkable thermoresponsive PNVCL nanoshells for cancer theranostics

Abstract: NIR light-responsive gold coated shrinkable thermoresponsive nanoshells as preliminary step to ablate large and deep-seated tumors using combined chemo-photothermal therapy.

Cited by 23 publications

References 41 publications

Characterization of Thermoresponsive Poly-N-Vinylcaprolactam Polymers for Biological Applications

Characterization of Thermoresponsive Poly-N-Vinylcaprolactam Polymers for Biological Applications

<p>Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems</p>

Doxorubicin Loaded-UiO-66-NH2 Coated With Poly(N-Vinylcaprolactam) For Controlled Release of Doxorubicin Against A549 Lung Cancer

Contact Info

Product

Resources

About