NIR nanoprobe-facilitated cross-referencing manifestation of local disease biology for dynamic therapeutic response assessment

Wang, Zhimin; Ai, Xiangzhao; Zhang, Zhijun; Wang, Yong; Wu, Xiangyang; Haindl, Richard; Yeow, Edwin K. L.; Drexler, Wolfgang; Gao, Mingyuan; Xing, Bengang

doi:10.1039/c9sc04909f

Cited by 28 publications

(31 citation statements)

References 55 publications

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“…Similar in vivo multivariate diagnosis has been pursued by other authors, but relying on analyte quantification through steady-state ratiometric PL strategies: one emission band of the RENPs may remain constant and is used as a reference, while another one varies in intensity due to the presence of the target analyte. 93,[98][99][100][101] It is important to highlight that these works focus on detecting analytes that can cause cellular oxidative stress (e.g. metformin) or are result-products of it, such as: peroxynitrite, hypochlorous acid, or hydrogen peroxide.…”

Section: Nanoscale Advances Accepted Manuscriptmentioning

confidence: 99%

“…metformin) or are result-products of it, such as: peroxynitrite, hypochlorous acid, or hydrogen peroxide. 93,[98][99][100][101] As a consequence, their oxidative properties are used to chemically modify the FRET acceptor, usually a cyanine dye that acts by quenching one of the RENPs emission bands. Upon oxidation, the optical properties (e.g., absorbance) of the FRET acceptor change and the otherwise quenched emission band from RENPs is restored.…”

Section: Nanoscale Advances Accepted Manuscriptmentioning

confidence: 99%

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Near infrared bioimaging and biosensing with semiconductor and rare-earth nanoparticles: recent developments in multifunctional nanomaterials

et al. 2021

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Section: Nanoscale Advances Accepted Manuscriptmentioning

confidence: 99%

Section: Nanoscale Advances Accepted Manuscriptmentioning

confidence: 99%

Near infrared bioimaging and biosensing with semiconductor and rare-earth nanoparticles: recent developments in multifunctional nanomaterials

et al. 2021

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“…152 PAI probes can be used to image deeper into tissue to, e.g., allow for whole body mouse, rat, and human organ imaging, 153,154,[154][155][156][157][158][159][160] to enhance the signal-to-background ratio, 161 for phototherapy and photoactivation, 151,162 and for molecularly targeted imaging. 149,152,158 Molecular targeting can involve the qualitative or quantitative detection of potential biomarkers such as reactive oxygen species, 163,164 pH, 165,166 Ca 2þ , [167][168][169][170][171] matrix metalloproteinases, 172 and granzyme B. 173 Biomarker imaging has mainly been demonstrated in animal models for various types of cancer, sentinel lymph nodes, liver dysfunction, and PAI of T lymphocytes, whereas intraoperative multimodal pancreatic cancer detection was already performed in humans.…”

Section: Contrast Agents In Oct and Paimentioning

confidence: 99%

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

et al. 2021

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Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance.Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis.Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results:The most disruptive future OCT innovations include imaging resolution and speed (single-beam raster scanning versus parallelization) improvement, new implementations for dual modality or even multimodality systems, and using endogenous or exogenous contrast in these hybrid OCT systems targeting molecular and metabolic imaging. Aside from OCT angiography, no other functional or contrast enhancing OCT extension has accomplished comparable clinical and commercial impacts. Some more recently developed extensions, e.g., optical coherence elastography, dynamic contrast OCT, optoretinography, and artificial intelligence enhanced OCT are also considered with high potential for the future. In addition, OCT miniaturization for portable, compact, handheld, and/or cost-effective capsule-based OCT applications, home-OCT, and self-OCT systems based on micro-optic assemblies or photonic integrated circuits will revolutionize new applications and availability in the near future. Finally, clinical translation of OCT including medical device regulatory challenges will continue to be absolutely essential.Conclusions: With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OCT has not been completely exploited and has substantial growth potential-in academics as well as in industry. This applies not only to the ophthalmic application field, but also especially to the original motivation of OCT to enable optical biopsy, i.e., the in situ imaging of tissue microstructure with a resolution approaching that of histology but without the need for tissue excision.

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“…Thus, the probe provides a spectrally opposite dual‐modal ratiometric output that allows a more sensitive and accurate evaluation of local disease biology and drug treatment responses based on the self‐calibrating feature of the reverse‐ratiometric PA and UCL imaging technology. [ 26 ]…”

Section: Development Of Smart Probesmentioning

confidence: 99%

Nanoparticle‐Based Activatable Probes for Bioimaging

Xia

2021

Advanced Biology

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Molecular imaging can provide functional and molecular information at the cellular or subcellular level in vivo in a noninvasive manner. Activatable nanoprobes that can react to the surrounding physiological environment or biomarkers are appealing agents to improve the efficacy, specificity, and sensitivity of molecular imaging. The physiological parameters, including redox status, pH, presence of enzymes, and hypoxia, can be designed as the stimuli of the activatable probes. However, the success rate of imaging nanoprobes for clinical translation is low. Herein, the recent advances in nanoparticle‐based activatable imaging probes are critically reviewed. In addition, the challenges for clinical translation of these nanoprobes are also discussed in this review.

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NIR nanoprobe-facilitated cross-referencing manifestation of local disease biology for dynamic therapeutic response assessment

Abstract: NIR photoacoustic and upconversion luminescent nanoprobe-facilitated cross-referencing manifestation of oxidative stress-induced liver pathophysiology for dynamic therapeutic response assessment.

Cited by 28 publications

References 55 publications

Near infrared bioimaging and biosensing with semiconductor and rare-earth nanoparticles: recent developments in multifunctional nanomaterials

Near infrared bioimaging and biosensing with semiconductor and rare-earth nanoparticles: recent developments in multifunctional nanomaterials

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

Nanoparticle‐Based Activatable Probes for Bioimaging

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