NIR Photoresponsive Crosslinked Upconverting Nanocarriers Toward Selective Intracellular Drug Release

Yang, Yanmei; Velmurugan, Bhaarathy; Liu, Xiaogang; Xing, Bengang

doi:10.1002/smll.201201765

Cited by 175 publications

(121 citation statements)

References 88 publications

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“…Later, Almutairi et al [150] and Xing et al [151] applied this strategy to induce the disruption of nanocarriers and subsequent release of coumarin 153 and DOX, respectively. In Almutairi's report, the NIR-induced disruption was achieved by a cascade of cyclization and rearrangement reactions of the polymer chains consisting of o-nitrobenzyl-functionalized cresol monomer.…”

Section: Caging Groupmentioning

confidence: 98%

Upconversion Nanoparticles for Light-Activated Therapy

Zhang¹

2014

Photon Upconversion Nanomaterials

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Light-activated therapy (LAT) has attracted enormous attention over the past decades because light enables noninvasive activation or release of various therapeutic compounds, such as photosensitizers, chemotherapeutic drugs, proteins, and genes with high spatial and temporal resolution. However, most currently used photosensitive compounds in LAT are sensitive to ultraviolet (UV) or visible light which suffers from some limitations such as low tissue penetration and photodamage to living organisms. Upconversion nanoparticles (UCNPs) that can convert near-infrared (NIR) light to visible/UV light have been proven to be effective for LAT in vivo in recent years, owing to the high tissue penetration and minimal photocytotoxicity of NIR light. Furthermore, hydrophilic UCNPs with targeting moieties can transport hydrophobic drugs in biological media and achieve active targeting, thus enhancing the therapeutic efficacy. In this chapter, we review the recent advances in the field of UCNP-based LAT with focus on photodynamic therapy (PDT) and NIR light-triggered release and uncaging.Keywords Light-activated therapy Á Upconversion nanoparticles Á Near-infrared excitation Á Photodynamic therapy Á Photosensitizer Á Light-triggered drug release Á Uncaging IntroductionThe past decades have seen considerable interest and progress in light-activated therapy (LAT), including photodynamic therapy (PDT), chemotherapy, gene therapy, and photothermal therapy (PTT) as light is noninvasive and controllable both spatially and temporally compared to other stimuli such as temperature, pH, ultrasound, and applied magnetic or electric fields [1,2]. Owing to these Zhenzhen Guo and Fan Zhang contributed together to this chapter.© Springer-Verlag Berlin Heidelberg 2015 F. Zhang, Photon Upconversion Nanomaterials, Nanostructure Science and Technology, DOI 10.1007/978-3-662-45597-5_9 285 advantages, this effective therapeutic approach is beneficial to control drug dosing in terms of quantity, location, and time, hence maximizing therapeutic effect while minimizing side effects [3]. However, the excitation of most commonly used photosensitizers for PDT and photoactive molecules for the release of chemotherapeutic drugs and genes relies on high-energy ultraviolet (UV) or visible light irradiation [4,5]. The tissue penetration depth of UV-visible light is shallow because of the scattering and absorption by tissue chromophores [6]. What is worse, the heterocyclic bases of DNA are major UV-absorbing chromophores in the skin. The absorption leads to damage of the DNA, which may result in the generation of tumors [7]. These limitations would greatly hamper their applications in vivo. Compared to UV and visible light, near-infrared (NIR) light has a larger penetration depth, lower levels of the auto-fluorescence , and photodamage effect [8] and is thus better suited for biomedical applications. Therefore, another component that is capable of converting NIR excitation into UV or visible emission should be introduced into current LAT systems in o...

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Section: Caging Groupmentioning

confidence: 98%

Upconversion Nanoparticles for Light-Activated Therapy

Zhang¹

2014

Photon Upconversion Nanomaterials

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“…In other systems, the UCNPs were used as a mediator to absorb the NIR photons and convert them into high energy photons (from the UV to the NIR region) used to trigger drug release 59,60 or to promote cell targeting. 61 For instance, Dox-loaded PEGylated NaYF 4 Yb, Tm@SiO 2 UCNPs were functionalized with caged FA using the o-nitrobenzylphotolabile group.…”

Section: Lanthanide-doped Upconversion Nanotheranosticsmentioning

confidence: 99%

Optical Imaging and Chemotherapy

Bort

Mura

Couvreur

2016

Nanotheranostics for Personalized Medicine

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Nanoscale drug delivery systems which combine in a single tool imag ing and therapeutic functions, (i.e., nanotheranostics) have attracted a great deal of interest due to the possibility to monitor in real-time both distribution/drug release and the effectiveness of the treatment thus, allowing an immediate adjustment of the therapeutic protocol. Among the various modalities, this chapter will focus on the optical imaging combined to the delivery of anticancer drugs and the main achievement obtained in this fi eld will be discussed. Nanotheranostics displaying multi-imaging properties will be also presented.Nanotheranostics for Personalized Medicine Downloaded from www.worldscientific.com by NANYANG TECHNOLOGICAL UNIVERSITY on 06/21/16. For personal use only.

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“…These upconversion nanomaterials are very different from traditional dyes because they are capable of absorbing and combining multiple low energy photons and then releasing a single higher energy photon in an anti-Stokes emission process. Because no biological fluorophores are capable of producing similar behavior, interference from auto-fluorescence can be eliminated and thus high imaging quality can be achieved[51]. This feature renders upconversion fluorescent lanthanide complexes promising for targeted surgery, though so far there are no reports of their application to surgery guidance.…”

Section: Target-specific Fluorescent Probes: the Driving Force Formentioning

confidence: 99%

Fluorescent imaging of cancerous tissues for targeted surgery

Bu¹,

Shen

Cheng

2014

Advanced Drug Delivery Reviews

111

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To maximize tumor excision and minimize collateral damage is the primary goal of cancer surgery. Emerging molecular imaging techniques have to “image-guided surgery” developing into “molecular imaging-guided surgery”, which is termed “targeted surgery” in this review. Consequently, the precision of surgery can be advanced from tissue-scale to molecule-scale, enabling “targeted surgery” to be a component of “targeted therapy”. Evidence from numerous experimental and clinical studies has demonstrated significant benefits of fluorescent imaging in targeted surgery with preoperative molecular diagnostic screening. Fluorescent imaging can help to improve intraoperative staging and enable more radical cytoreduction, detect obscure tumor lesions in special organs, highlight tumor margins, better map lymph node metastases, and identify important normal structures intraoperatively. Though limited tissue penetration of fluorescent imaging and tumor heterogeneity are two major hurdles for current targeted surgery, multimodality imaging and multiplex imaging may provide potential solutions to overcome these issues, respectively. Moreover, though many fluorescent imaging techniques and probes have been investigated, targeted surgery remains at a proof-of-principle stage. The impact of fluorescent imaging on cancer surgery will likely be realized through persistent interdisciplinary amalgamation of research in diverse fields.

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NIR Photoresponsive Crosslinked Upconverting Nanocarriers Toward Selective Intracellular Drug Release

Cited by 175 publications

References 88 publications

Upconversion Nanoparticles for Light-Activated Therapy

Upconversion Nanoparticles for Light-Activated Therapy

Optical Imaging and Chemotherapy

Fluorescent imaging of cancerous tissues for targeted surgery

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