NIR-responsive multi-healing HMPAM/dextran/AgNWs hydrogel sensor with recoverable mechanics and conductivity for human-machine interaction

Ding, Jie; Qiao, Zi; Zhang, Yusheng; Wei, Danrui; Chen, Suping; Tang, Jiajia; Chen, Lu; Wei, Dan; Sun, Jing; Fan, Hongsong

doi:10.1016/j.carbpol.2020.116686

Cited by 45 publications

(33 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydrogels have been widely applied in the biomedical field as drug and cell delivery vehicles, bioadhesives, regenerative scaffolds, engineered tissue, wound dressings, and postoperative antiadhesion barriers . Because of their high water content, soft mechanical properties, good biocompatibility, and physical similarity with biological tissues, hydrogels are superior drug delivery carriers. − As drug-loaded hydrogels may be exposed to different physiological environments, they are often required to have various properties such as a self-healing ability, adjustable mechanical strength, and thermoplasticity, which rely on the design of supramolecular physical interactions in the hydrogel network, such as hydrogen bond interactions, − host–guest interactions, metal–ligand coordination interactions, hydrophobic interactions, , and multiple combinatorial interactions . Among them, hydrogen bonds are generally weak noncovalent bonds, ubiquitous in biomolecules, but their cooperative interaction can reach the strength of covalent bonds; therefore, they are commonly used to design self-assembled supramolecular hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Facile Preparation of Drug-Releasing Supramolecular Hydrogel for Preventing Postoperative Peritoneal Adhesion

Song

Zhang

Shen

et al. 2021

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Hydrogels have attracted widespread attention for breaking the bottlenecks faced during facile drug delivery. To date, the preparation of jelly carriers for hydrophobic drugs remains challenging. In this study, by evaporating ethanol to drive the formation of hydrogen bonds, hydrophilic poly(vinyl alcohol) (PVA) and certain hydrophobic compounds [luteolin (LUT), quercetin (QUE), and myricetin (MYR)] were rapidly prepared into supramolecular hydrogel within 10 min. The gelation performance of these three hydrogels changed regularly with the changing sequence of LUT, QUE, and MYR. An investigation of the gelation pathway of these hybrid gels reveals that the formation of this type of gel follows a simple supramolecular self-assembly process, called "hydrophobe−hydrophile crosslinked gelation". Because the hydrogen bond between PVA and the drug is noncovalent and reversible, the hydrogel has good plasticity and self-healing properties, while the drugs can be controllably released by tuning the output stimuli. Using a rat sidewall-cecum abrasion adhesion model, the as-prepared hydrogel was highly efficient and safe in preventing postsurgical adhesion. This work provides a useful archetypical template for researchers interested in the efficient delivery and controllable release of hydrophobic drugs.

show abstract

Section: Introductionmentioning

confidence: 99%

Facile Preparation of Drug-Releasing Supramolecular Hydrogel for Preventing Postoperative Peritoneal Adhesion

Song

Zhang

Shen

et al. 2021

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Modifications such as the development of skin-inspired and patterned mesh to adapt to the human body’s curvilinear surface allows for better-adapted sensors [ 15 ]. Materials such as hydrogels, textiles, and paper have been mainstreamed for the development of wearable biosensors, as they provide a flexible, stretchable, and breathable platform for potential applications as wearable biosensors [ 16 , 17 , 18 , 19 ].…”

Section: Design Ideal Requirements and Types Of Wearable Biosensorsmentioning

confidence: 99%

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

et al. 2021

View full text Add to dashboard Cite

In the past decade, wearable biosensors have radically changed our outlook on contemporary medical healthcare monitoring systems. These smart, multiplexed devices allow us to quantify dynamic biological signals in real time through highly sensitive, miniaturized sensing platforms, thereby decentralizing the concept of regular clinical check-ups and diagnosis towards more versatile, remote, and personalized healthcare monitoring. This paradigm shift in healthcare delivery can be attributed to the development of nanomaterials and improvements made to non-invasive biosignal detection systems alongside integrated approaches for multifaceted data acquisition and interpretation. The discovery of new biomarkers and the use of bioaffinity recognition elements like aptamers and peptide arrays combined with the use of newly developed, flexible, and conductive materials that interact with skin surfaces has led to the widespread application of biosensors in the biomedical field. This review focuses on the recent advances made in wearable technology for remote healthcare monitoring. It classifies their development and application in terms of electrochemical, mechanical, and optical modes of transduction and type of material used and discusses the shortcomings accompanying their large-scale fabrication and commercialization. A brief note on the most widely used materials and their improvements in wearable sensor development is outlined along with instructions for the future of medical wearables.

show abstract

“…This hydrogel contains many hydrogen bonds and can heal itself within 3 s without any external stimulation at room temperature. Ding et al [142] proposed a self-healing hydrogel-based sensor with conductivity, antibacterial and self-healing properties consisting of hydrophobic modified polyacrylamide (HMPAM), bis (acryloyl) cystamine (BACA)-modified silver nanowires (AgNWs) and dextran, as shown in Figure 4a. This sensor had ultralow strain (0.05%), a wide strain sensing window (0.05-1200%), a wide operating frequency range and superior cycle stability (200 relatively low resistance changes).…”

Section: Metal-based Nanomaterialsmentioning

confidence: 99%

Self-Healing Mechanism and Conductivity of the Hydrogel Flexible Sensors: A Review

Zhang

Wang

Wei

et al. 2021

Gels

View full text Add to dashboard Cite

Sensors are devices that can capture changes in environmental parameters and convert them into electrical signals to output, which are widely used in all aspects of life. Flexible sensors, sensors made of flexible materials, not only overcome the limitations of the environment on detection devices but also expand the application of sensors in human health and biomedicine. Conductivity and flexibility are the most important parameters for flexible sensors, and hydrogels are currently considered to be an ideal matrix material due to their excellent flexibility and biocompatibility. In particular, compared with flexible sensors based on elastomers with a high modulus, the hydrogel sensor has better stretchability and can be tightly attached to the surface of objects. However, for hydrogel sensors, a poor mechanical lifetime is always an issue. To address this challenge, a self-healing hydrogel has been proposed. Currently, a large number of studies on the self-healing property have been performed, and numerous exciting results have been obtained, but there are few detailed reviews focusing on the self-healing mechanism and conductivity of hydrogel flexible sensors. This paper presents an overview of self-healing hydrogel flexible sensors, focusing on their self-healing mechanism and conductivity. Moreover, the advantages and disadvantages of different types of sensors have been summarized and discussed. Finally, the key issues and challenges for self-healing flexible sensors are also identified and discussed along with recommendations for the future.

show abstract

NIR-responsive multi-healing HMPAM/dextran/AgNWs hydrogel sensor with recoverable mechanics and conductivity for human-machine interaction

Cited by 45 publications

References 55 publications

Facile Preparation of Drug-Releasing Supramolecular Hydrogel for Preventing Postoperative Peritoneal Adhesion

Facile Preparation of Drug-Releasing Supramolecular Hydrogel for Preventing Postoperative Peritoneal Adhesion

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

Self-Healing Mechanism and Conductivity of the Hydrogel Flexible Sensors: A Review

Contact Info

Product

Resources

About