NIR‐Responsive Upconversion Nanoparticles Stimulate Neurite Outgrowth in PC12 Cells

Guan, Yijia; Li, Meng; Dong, Kai; Ren, Jinsong; Qu, Xiaogang

doi:10.1002/smll.201400612

Cited by 28 publications

(27 citation statements)

References 36 publications

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“…These conclusions are in line with other studies where it is shown that the nano-structured scaffolds augment cell-material interactions at different steps, such as initial attachment, differentiation of neuronal lineage, and neuronal phenotype and length [26,27,28,29,30,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57]. It has also been demonstrated by others that nano-topographical features can act as guidance cues to glia and neuron growth on the surface [27,45,47,50,51,53,54].…”

Section: Resultssupporting

confidence: 92%

Nanocarbon-Coated Porous Anodic Alumina for Bionic Devices

et al. 2015

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A highly-stable and biocompatible nanoporous electrode is demonstrated herein. The electrode is based on a porous anodic alumina which is conformally coated with an ultra-thin layer of diamond-like carbon. The nanocarbon coating plays an essential role for the chemical stability and biocompatibility of the electrodes; thus, the coated electrodes are ideally suited for biomedical applications. The corrosion resistance of the proposed electrodes was tested under extreme chemical conditions, such as in boiling acidic/alkali environments. The nanostructured morphology and the surface chemistry of the electrodes were maintained after wet/dry chemical corrosion tests. The non-cytotoxicity of the electrodes was tested by standard toxicity tests using mouse fibroblasts and cortical neurons. Furthermore, the cell–electrode interaction of cortical neurons with nanocarbon coated nanoporous anodic alumina was studied in vitro. Cortical neurons were found to attach and spread to the nanocarbon coated electrodes without using additional biomolecules, whilst no cell attachment was observed on the surface of the bare anodic alumina. Neurite growth appeared to be sensitive to nanotopographical features of the electrodes. The proposed electrodes show a great promise for practical applications such as retinal prostheses and bionic implants in general.

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Section: Resultssupporting

confidence: 92%

Nanocarbon-Coated Porous Anodic Alumina for Bionic Devices

et al. 2015

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“…Since lanthanide‐doped upconversion nanoparticles (UCNPs) possess the intrinsic properties of absorbing and converting near‐infrared (NIR) light into high‐energy UV, visible, or NIR irradiation, they have been widely applied in biodetection, nanomedicines, and information security . In our previous studies, UCNPs have been used for on‐demand manipulation of cell behaviors, such as cell capture and release and neurite outgrowth of PC12 cells . Bian et al.…”

Section: Methodsmentioning

confidence: 99%

Photocontrolled Multidirectional Differentiation of Mesenchymal Stem Cells on an Upconversion Substrate

et al. 2018

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The effective guidance of mesenchymal stem cell (MSC) differentiation on a substrate by near-infrared (NIR) light is particularly attractive for tissue engineering and regenerative medicine. However, most of current substrates cannot control multidirectional differentiation of MSCs like natural tissues. Herein, a photocontrolled upconversion-based substrate was designed and constructed for guiding multidirectional differentiation of MSCs. The substrate enables MSCs to maintain their stem-cell characteristics due to the anti-adhesive effect of 4-(hydroxymethyl)-3-nitrobenzoic acid modified poly(ethylene glycol) (P1) attached on the upconversion substrate. Upon NIR irradiation, the P1 is released from the substrate by photocleavage. The detachment of P1 can change cell-matrix interactions dynamically. Moreover, MSCs cultured on the upconversion substrate can be specifically induced to differentiate to adipocytes or osteoblasts by adjusting the NIR laser. Our work provides a new way of using NIR-based upconversion substrate to modulate the multidirectional differentiation of MSCs.

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“…To harness the brain's regenerative capacity in order to promote cognition and ameliorate the loss of neural functions in case of injury or disease has been a priority for people in this domain. There is a great demand for therapeutic strategies to boost nerve cell growth and trigger nerve fiber reconnections . Conventional methods use injection of nerve growth factors (NGF), however quick clearance, short half‐life, and degradation of these NGFs is a setback to the healing process and leads to a reduced effective concentration reaching the damaged nerves …”

Section: Applications Of Msnsmentioning

confidence: 99%

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

Mendiratta

Hussein

Nasser

et al. 2019

Part & Part Syst Charact

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that by 2040, neurodegenerative diseases will surpass cancer as the second reason of death after cardiovascular diseases in such aged populations. [1,2] As per a 2017 report, neurological diseases cost the United States of America about $800 billion annually and this number is expected to increase even further over the coming years as the percentage of aged citizens increases. [3] Unlike most other major diseases, the pace of drug development and delivery in case of neurodegenerative diseases has been stationary, partially due to lack of biomarkers that can diagnose such diseases long before the neurological symptoms arise and the challenges associated with identification of targets for drugs that can terminate or minimize neurodegeneration. Most importantly, delivering new cerebral therapeutic agents is impeded by the extensive and robust blood-brain barrier (BBB) which prevents the vast majority of drugs from crossing to the brain after systemic administration. During brain infections, intracerebral hemorrhage, or in neurodegenerative disorders, the BBB is altered in such a way that it allows easy access of inflammatory inducing molecules that may cause adverse neuronal damage. [4] Given the importance of early diagnosis and treatment of neurodegenerative diseases, new drug delivery technologies have appeared in the last decade.As shown in Scheme 1, unique nanomaterials have been reported and several nanosized drug delivery systems including liposomes, dendrimers, carbon nanotubes (CNTs), inorganic and hybrid nanoparticles, and polymeric micelles have gained attention and have been tested for targeted drug delivery not only for neurodegenerative diseases but also for several other ailments. [5][6][7][8][9][10] The discovery of MCM-41 was recognized as a major breakthrough in materials science and since then mesoporous silica nanoparticles (MSNs), thanks to their superior physiochemical properties such as large porosity, high surface areas, low toxicity, controllable sizes, and wide range of morphologies compared to conventional nanoparticles (NPs) have emerged as favorable tools in biomedical applications as nanocarriers for encapsulation and delivery of therapeutic medicines. [11][12][13][14] Designing biocompatible MSNs and their multifunctional derivatives for drug transport as well as theranostics is one of the hottest areas of research in the field of nanobiotechnology and nanomedicine. [15][16][17][18][19] High loading capacity, acceptable biocompatibility, and limitless possibilities of surface functionalization for specific cellular recognition Mesoporous silica nanoparticles (MSNs) have gained wide attention for their role in biomedicine and as drug delivery vehicles. Their structural tunability, high surface area, and easy functionalization impart significant advantages over conventional materials. In this Review, recent advances in the synthesis, drug delivery, and therapeutic roles of MSNs in the treatment of various neurodegenerative and neuroinflammatory diseases are presented. The intention is to...

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NIR‐Responsive Upconversion Nanoparticles Stimulate Neurite Outgrowth in PC12 Cells

Cited by 28 publications

References 36 publications

Nanocarbon-Coated Porous Anodic Alumina for Bionic Devices

Nanocarbon-Coated Porous Anodic Alumina for Bionic Devices

Photocontrolled Multidirectional Differentiation of Mesenchymal Stem Cells on an Upconversion Substrate

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

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