NIR-triggerable ROS-responsive cluster-bomb-like nanoplatform for enhanced tumor penetration, phototherapy efficiency and antitumor immunity

Zhang, Yu; Du, Xiyou; Liu, Shangui; Yan, Hong; Ji, Jianbo; Xi, Yang; Yang, Xiaoye; Zhai, Guangxi

doi:10.1016/j.biomaterials.2021.121135

Cited by 49 publications

(24 citation statements)

References 49 publications

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“…Smart nanomedicines with high penetration-promoting properties can be classified as size-shrinkable nanoparticles, “cluster bomb”-like sequential-releasing nanoparticles, charge-reversal nanoparticles, and penetrating peptide-modified nanoparticles 27 . For instance, Shen et al devoted considerable effort to producing charge-transformable nanocarriers in response to special enzymes with high expression levels in tumor tissue, achieving high accumulation and deep tumor penetration via transcytosis effects across vascular endothelial cells and tumor cells 24 , 28 .…”

Section: Introductionmentioning

confidence: 99%

“…However, endogenous stimuli affected by tumor heterogeneity might reduce the responsiveness of the nanocarriers, impeding their further application. Exogenous stimuli, such as: light, radiation, heat, and electric and magnetic fields, are more controllable and homogeneous 27 , 29 - 31 . Among them, NIR light in the “therapeutic window” (720-900 nm) is considered to be one of the most promising stimuli because of its advantages of: spatiotemporal control, deep tissue penetration, non-invasion, and safety 27 , 31 .…”

Section: Introductionmentioning

confidence: 99%

“…Exogenous stimuli, such as: light, radiation, heat, and electric and magnetic fields, are more controllable and homogeneous 27 , 29 - 31 . Among them, NIR light in the “therapeutic window” (720-900 nm) is considered to be one of the most promising stimuli because of its advantages of: spatiotemporal control, deep tissue penetration, non-invasion, and safety 27 , 31 . Nevertheless, most of these transformable nanocarriers are triggered by a single stimulus.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

Peng¹,

Chen²,

Liu³

et al. 2022

Theranostics

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Designing a transformable nanosystem with improved tumor accumulation and penetration by tuning multiple physicochemical properties remains a challenge. Here, a near-infrared (NIR) light-driven nanosystem with size and charge dual-transformation for deep tumor penetration is developed. Methods: The core-shell nanotransformer is realized by integrating diselenide-bridged mesoporous organosilica nanoparticles as a reactive oxygen species (ROS)-responsive core with an indocyanine green (ICG)-hybrid N-isopropyl acrylamide layer as a thermosensitive shell. After loading doxorubicin (DOX), negatively charged nanomedicine prevents DOX leakage, rendering prolonged blood circulation time and high tumor accumulation. Results: Upon NIR light irradiation, mild photothermal effects facilitate the dissociation of the thermosensitive shell to achieve negative-to-positive charge reversal. Meanwhile, ICG-generated ROS cleave the diselenide bond of the organosilica core, resulting in rapid matrix degradation that produces DOX-containing smaller fragments. Such a light-driven dual-transformable nanomedicine simultaneously promotes deep tumor penetration and implements sufficient chemotherapy, along with evoking robust immunogenic cell death effects in vitro and in vivo . With the combination of a programmed cell death protein-1 (PD-1) checkpoint blockade, the nanotransformer remarkably blocks primary tumor growth and pulmonary metastasis of breast cancer with low systemic toxicity. Conclusions: This study develops a promising strategy to realize high tumor accumulation and deep penetration of light-transformable nanomedicine for efficient and safe chemo-immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

Peng¹,

Chen²,

Liu³

et al. 2022

Theranostics

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“…The lack of deep infiltration of tumor tissue is a major limitation of drug therapy. In addition to active targeting, Yang et al 114 for the first-time combined size-transforming and transcytosis strategies, which effectively enhanced passive diffusion and active transport to construct anti-tumor immune nanodrugs with efficient delivery efficiency (named CPIM) (Figure 20 A). In terms of passive diffusion, cluster-bomb-like nanoplatforms (135 nm) release small drug-loaded “particles” (PAMAM loaded with IR780/1- methyltryptophan (1-MT), particle size < 10 nm) under the action of high concentrations of ROS in the TME, and promote the permeation and diffusion of IR780 and 1-MT in tumor tissue.…”

Section: Pdt Combined With Other Therapiesmentioning

confidence: 99%

How to improve photodynamic therapy-induced antitumor immunity for cancer treatment?

Zhang

Zhao

et al. 2022

Theranostics

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Photodynamic therapy (PDT) is a promising method of tumor ablation and function-preserving oncological intervention, which is minimally invasive, repeatable, and has excellent function and cosmetic effect, with no cumulative toxicity. More importantly, PDT can induce immunogenic cell death and local inflammation, thus stimulating the body's immune response. However, the weak immunity induced by PDT alone is insufficient to trigger a systemic immune response towards cancer cells. To overcome this obstacle, multiple strategies have been investigated, including tumor microenvironment remodeling, tumor vaccines, subcellular-targeted PDT, and synergistic therapies. This review summarizes the latest progress in the development of strategies to improve the PDT-induced immune effect for enhanced cancer treatment.

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“…In recent years, with the increasing understanding of cancer and its interaction with the immune system, cancer immunotherapy, which trains or stimulates the body’s innate immune system to attack tumor cells, has made rapid progress and shows great promise as the next generation of cancer treatment strategies (Palucka & Banchereau, 2012 ; Liu et al., 2018 ). Accumulating evidence suggests that additional engagement of the immune response contributes significantly to the over antitumor efficacy of cancer therapy (Galluzzi et al., 2012 ; Yoon et al., 2018 ): for instance, certain chemotherapeutic agents (e.g., oxaliplatin and anthracyclines) and exogenous stimulus (e.g., photodynamic therapy) induce immunogenic cell death (ICD) in tumor cells (Huang et al., 2019 ; Zhang et al., 2021 ). Apoptosis has been considered as a procedural form of cell death with poor immunogenicity and physiology (Erwig & Henson, 2008 ; Tesniere et al., 2008; Green et al., 2009 ; Morioka et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity

Zhu

Yang

et al. 2022

Drug Delivery

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We fabricated an ultrasound activated ‘nanobomb’ as a noninvasive and targeted physical therapeutic strategy for sonodynamic therapy and priming cancer immunotherapy. This ‘nanobomb’ was rationally designed via the encapsulation of indocyanine green (ICG) and perfluoropentane (PFP) into cRGD peptide-functionalized nano-liposome. The resulting Lip-ICG-PFP-cRGD nanoparticle linked with cRGD peptide could actively targeted ID8 and TC-1 cells and elicits ROS-mediated apoptosis after triggered by low-intensity focused ultrasound (LIFU). Moreover, the phase change of PFP (from droplets to microbubbles) under LIFU irradiation can produce a large number of microbubbles, which act as intra-tumoral bomber and can detonate explode tumor cells by acoustic cavitation effect. Instant necrosis of tumor cells further induces the release of biologically active damage-associated molecular patterns (DAMPs) to facilitate antitumor immunity. More important, the ‘nanobomb’ in combination with anti-PD-1checkpoint blockade therapy can significantly improve the antitumor efficacy in a subcutaneous model. In addition, the liposomes may also be used as an imaging probe for ultrasound (US) imaging after being irradiated with LIFU. In summary, the US imaging-guided, LIFU activated ROS production and explosion ‘nanobomb’ might significantly improve the antitumor efficacy and overcome drug resistance through combination of SDT and immunotherapy, we believe that this is a promising approach for targeted therapy of solid tumor including ovarian cancer.

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NIR-triggerable ROS-responsive cluster-bomb-like nanoplatform for enhanced tumor penetration, phototherapy efficiency and antitumor immunity

Cited by 49 publications

References 49 publications

A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

How to improve photodynamic therapy-induced antitumor immunity for cancer treatment?

Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity

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