NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

Abstract

Construction of localized drug‐eluting systems with synergistic chemothermal tumor‐killing abilities is promising for biomedical implants directly contacting with tumor tissues. In this study, an intelligent and biocompatible drug‐loading platform, based on a gold nanorods‐modified butyrate‐inserted NiTi‐layered double hydroxides film (Au@LDH/B), is prepared on the surface of nitinol alloy. The prepared films function as drug‐loading “sponges,” which pump butyrate out under near‐infrared (NIR) irradiation and resorb drugs in water when the NIR laser is shut off. The stimuli‐responsive release of butyrate is verified to be related with the NIR‐triggered crystal phase transformation of Au@LDH/B. In vitro and in vivo studies reveal that the prepared films possess excellent biosafety and high efficiency in synergistic thermochemo tumor therapy, showing a promising application in the construction of localized stimuli‐responsive drug‐delivery systems.

Biocompatible Hydrotalcite Nanohybrids for Medical Functions

“…In biomedical applications, one of the most significant factors in utilizing layered nanomaterials is biocompatibility. Among various 2D layered crystal structures, LDHs have been established as highly biocompatible, and their related nanohybrids are readily applicable for therapeutic and diagnostic uses such as anti-cancer, anti-inflammatory, antibiotic, antioxidant efficacy, and bio-imaging [33][34][35][36][37][38][39][40][41][42][43][44]. As has been well documented, efficient drug delivery carriers should not only be biocompatible to ensure safety aspects of nano delivery vehicles, but also be suitable to stabilize and protect biomolecules against harsh physical and biochemical attacks in biological environments, subsequently to deliver genes/drugs into the target-specific tissue and release them in the controlled manner.…”

Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

“…A similar strategy was used to promote the transfer of butyrate ions between the nitinol stent and cancer cells, producing a selective anticancer effect. [ 256 ]…”

“…A similar strategy was used to promote the transfer of butyrate ions between the nitinol stent and cancer cells, producing a selective anticancer effect. [256] By coupling with external fields such as light, magnetic fields, and microwaves, the stimuli-responsive implants convert the energy of the external field into electrical energy; thus, regulating the electrochemical potential. Stimuli-responsive implants are also wireless devices with various advantageous characteristics such as simplicity and convenience.…”

Functional Layered Double Hydroxide Nanohybrids for Biomedical Imaging

“…There are some studies on LDH-based nanohybrids for multimodal imaging as well as desirable combination therapies, which use more than one medication or modality to realize synergistic treatment. LDHs have been extensively studied as a theranostic delivery carrier for a variety of therapies, including chemo-, gene-, photo-, boron neutron capture-, and even immunotherapy [64,65,66,67,68,69,70,71,72,73,74,75,76,77,78].…”