2023
DOI: 10.1007/s00109-023-02339-y
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Nischarin expression may have differing roles in male and female melanoma patients

Abstract: Due to the development of resistance to previously effective therapies, there is a constant need for novel treatment modalities for metastatic melanoma. Nischarin (NISCH) is a druggable scaffolding protein reported as a tumor suppressor and a positive prognostic marker in breast and ovarian cancers through regulation of cancer cell survival, motility and invasion. The aim of this study was to examine the expression and potential role of nischarin in melanoma. We found that nischarin expression was decreased in… Show more

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Cited by 2 publications
(5 citation statements)
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“…To test whether NISCH had different prognostic values in female and male patients, tumor samples were divided into sex subgroups and the best cut off value for survival analysis was applied for each newly formed subset of samples ( Table 2 ). As we previously reported [ 19 ], NISCH had the opposite prognostic value for female and male melanoma patients ( Fig 4D ). In some tumor types, like KIRC (unfavorable) and HNSC (favorable) the prognostic value stemmed from the male patient population that was represented 3 times more frequently but had the same trend in female patients ( S6 Fig ).…”
Section: Resultssupporting
confidence: 76%
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“…To test whether NISCH had different prognostic values in female and male patients, tumor samples were divided into sex subgroups and the best cut off value for survival analysis was applied for each newly formed subset of samples ( Table 2 ). As we previously reported [ 19 ], NISCH had the opposite prognostic value for female and male melanoma patients ( Fig 4D ). In some tumor types, like KIRC (unfavorable) and HNSC (favorable) the prognostic value stemmed from the male patient population that was represented 3 times more frequently but had the same trend in female patients ( S6 Fig ).…”
Section: Resultssupporting
confidence: 76%
“…In renal cancer more than 50% of samples did not express NISCH at all. We have previously reported the nuclear localization of NISCH in melanoma [ 19 ]. While the number of tumor samples stained in the HPA was too low for the statistical analysis with an appropriate power, it would be interesting to examine (in each tumor type individually), whether the NISCH localized in the nucleus has a specific role and an impact on tumor progression.…”
Section: Resultsmentioning
confidence: 99%
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