Nissl Granules, Axonal Regeneration, and Regenerative Therapeutics: A Comprehensive Review

Bhati, Manya; Thakre, Swedaj; Anjankar, Ashish

doi:10.7759/cureus.47872

Cited by 4 publications

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Ichipi-Ifukor,

Asagba,

Achuba

2024

Biol Trace Elem Res

View full text Add to dashboard Cite

Most research has not been done on the possible relationship between pregnant women' cross-metal exposures and postpartum neuroendocrine functions. The purpose of this study was to look into how coexposure to aluminium chloride (AlCl3) and cadmium chloride (CdCl2) affected the neuroendocrine and neurometabolic changes in postpartum mice A total of 24 adult pregnant female mice were used for the study. Group 1 comprised pregnant mice (n = 6) treated with AlCl 3 (10mg/kg), group 2; CdCl 2 (1.5mg/kg), group 3 a combination of AlCl 3 (10 mg/kg) and CdCl 2 (1.5 mg/kg) and group 4 served as control. Oral treatment of animals was done daily from gestation day 7 to gestation day 20. Upon delivery and weaning on postnatal day 21 (PND 21), behavioural assessment was done on the postpartum mice and immediately followed by sacri ce for assessment of histological and neuroendocrine markers. Our ndings revealed that the brain-to-body weight ratio was affected and brain oxidative stress was elevated in mice exposed to AlCl 3 and CdCl 2 during pregnancy. Given the strong association between postpartum hyperactivity, social interaction index, brain catalase, and acetylcholinesterase activity, and the brain/body weight ratio, it is plausible that these effects have played a role in the adverse behavioural abnormalities observed in the postpartum maternal mice. Moreover, it noted that in certain situations, coexposures to the metals tended to have opposite effects to single metal exposures.

show abstract

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Ichipi-Ifukor,

Asagba,

Achuba

2024

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

SEP-363856 attenuates CUMS-induced depression-like behaviours and reverses hippocampal neuronal injuries

Li,

Yang,

et al. 2024

The World Journal of Biological Psychiatry

View full text Add to dashboard Cite

Spondias mombin Ameliorates Copper‐Induced Memory Impairment in Mice by Mitigating Oxidative Stress and Modulating Cholinergic Activity

Agboola,

Joshua,

Ogunsanya

et al. 2024

Journal of Toxicology

View full text Add to dashboard Cite

The study unveils the importance of Spondias mombin leaf extract (S. mombin: 100 mg/kg b.wt.) in mitigating the toxic insult mediated by copper (16 mg/kg) on the cholinergic system via oral gavage. Male mice were weighed and distributed into five groups, six mice per group. Group A represents the basal control group given only distilled water; Group B and C were given 16 mg/kg of copper sulphate and 100 mg/kg of S. mombin methanol leaf extract, respectively, for 31 days; Group D was given 16 mg/kg of copper sulphate for 31 days, followed by treatment with 100 mg/kg of S. mombin methanol leaf extract for 15 days; and Group E was assigned only S. mombin. The copper concentration was evaluated using atomic absorption spectroscopy, while the cognitive abilities were assessed using Morris water maze and elevated plus‐maze. The result showed that S. mombin reversed the disparities in cholinesterase and choline acetyltransferase activities in vivo due to copper neurotoxicity, with a relative (p < 0.05) decrease in brain and blood copper concentration in co‐ and posttreatment groups. Furthermore, S. mombin reported decreased the disparity between pro‐ and antioxidant occurrence caused by copper toxicity by lowering brain lipid peroxidation, raising thiol levels, and increasing the activities of antioxidant enzymes such as glutathione transferase, catalase, and superoxide dismutase. The result showed that the extract had a protective influence on memory deficits (p < 0.05), significantly reduced anxiety levels, and increased the overall number of neurons in the hippocampus subfields. In conclusion, S. mombin ameliorates Cu‐induced neurotoxicity and neurocognitive dysfunctions by virtue of enhancement of cholinergic signalling and antioxidant activities in the brain.

show abstract

Nissl Granules, Axonal Regeneration, and Regenerative Therapeutics: A Comprehensive Review

Cited by 4 publications

References 55 publications

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

SEP-363856 attenuates CUMS-induced depression-like behaviours and reverses hippocampal neuronal injuries

Spondias mombin Ameliorates Copper‐Induced Memory Impairment in Mice by Mitigating Oxidative Stress and Modulating Cholinergic Activity

Contact Info

Product

Resources

About