Nitidine chloride induces apoptosis, cell cycle arrest, and synergistic cytotoxicity with doxorubicin in breast cancer cells

Sun, Mingxia; Zhang, Ning; Wang, Xiaolong; Cai, Chonghai; Cun, Jinjing; Li, Yaming; Lv, Shangge

doi:10.1007/s13277-014-2327-9

Cited by 45 publications

(40 citation statements)

References 40 publications

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“…Another study revealed that NC exposure led to inhibition of cell proliferation and induction of cell cycle arrest through elevation of multiple gene expressions such as p53, p21, Bax, and active forms of caspase-3, caspase-9, and cleaved PARP, and downregulation of Bcl-2 [9]. Notably, NC sensitizes cell sensitivity to doxorubicin for cell proliferation in breast cancer [9].…”

Section: Breast Cancermentioning

confidence: 99%

Antitumor functions and mechanisms of nitidine chloride in human cancers

Cui¹,

Wu²,

Cao³

et al. 2020

J. Cancer

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Nitidine chloride (NC), a quaternary ammonium alkaloid, exhibits multiple biological activities, including antimalarial, antifungal, and antiangiogenesis. Recently, NC has been characterized to perform antitumor activity in a variety of malignancies. NC has been identified to suppress cell proliferation, stimulate apoptosis, and induce cell cycle arrest, retard migration, invasion and metastasis. Moreover, NC is reported to sensitize cancer cells to chemotherapeutic drugs. In this review article, we describe the functions of NC in human cancers and discuss the molecular insight into NC-involved antitumor feature. This review article will stimulate the deeper investigation for using NC as a potent agent for the management of cancer patients.

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Section: Breast Cancermentioning

confidence: 99%

Antitumor functions and mechanisms of nitidine chloride in human cancers

Cui¹,

Wu²,

Cao³

et al. 2020

J. Cancer

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“…Bax, cleaved caspase-9 and -3 and cleaved PARP) and down-regulating anti-apoptotic proteins (e.g. Bcl-2 and PARP) [119,120] .…”

Section: Anticancermentioning

confidence: 99%

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Maji¹,

Banerji²

2015

Int. J. Herb. Med.

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Chelidonium majus L. (Papaveraceae) is a medicinal herb used in various traditional systems of medicine to treat ulcer, cancer, oral infection, liver disorders, chronic bronchitis, asthma, etc. Different parts of this plant contain numerous therapeutically important alkaloidal constituents such as chelidonine, chelerythrine, sanguinarine, berberine and so on. The plant and its active compounds exhibit a wide range of pharmacological activities. The plants has long history of therapeutic use in medicines without any toxic effect. Today it is one of the important components of some pharmaceutical preparations. Consumption of C. majus preparations possesses toxic effects on the liver although the effect becomes controversial with its hepatoprotective effect. Numerous active constituents of C. majus interact with various drug metabolizing enzymes that mimic possible interactions of this herb with the conventional drugs. This review provides detailed phytochemical, pharmacological and toxicological information of C. majus along with mechanisms of action of its various active compounds on different aspects of pharmacology. This review also highlights plausible drug interaction of its various active compounds and the future prospect of this herb.

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“…For other species of Orophea, O. uniflora is endemic in India whereas O. palawanensis is found in Philippines. Various bioactive alkaloids are extracted from medicinal herbs such as nitidine chloride from Zanthoxylum nitidum with anticancer effect against breast cancer cells (Sun et al, 2014). N-norchelerythrine and dihydrosanguinarine, from Broussonetia papyrifera (L.) Vent.…”

Section: Introductionmentioning

confidence: 99%