Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite‐mediated oxidative stress in neurodegenerative diseases

Aoyama, Koji; Matsubara, Kazuo; Fujikawa, Y.; Nagahiro, Yukio; Shimizu, Keiko; Umegae, Nobuyuki; Hayase, Nobumasa; Shiono, Hiroshi; Kobayashi, Shotai

doi:10.1002/1531-8249(200004)47:4<524::aid-ana19>3.3.co;2-x

Cited by 16 publications

(17 citation statements)

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“…The elevated CSF levels of 3-NT were reported also in other neurodegenerative disorders such as Parkinson's and Alzheimer's diseases (Aoyama et al 2000;Ryberg et al 2004).…”

Section: Potential Biomarkers Reflecting Oxidative Stress In Csfmentioning

confidence: 77%

CSF markers in amyotrophic lateral sclerosis

et al. 2012

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Amyotrophic lateral sclerosis (ALS, 'Lou Gehrig disease') is the most common, progressive, neurodegenerative, motor neuron disease, causing damage to upper and lower motor neurons, leading to paralysis and death within 3-5 years. Majority of ALS cases are sporadic ALS (SALS) and only 5-10 % of cases are familial ALS (FALS). Pathogenesis of ALS is complicated and still unclear, including genetic, glutamate excitotoxicity, oxidative stress, mitochondrial dysfunction, neurofilament accumulation, impaired trophic support, altered glial function, viral infection, immune imbalance and impairment of the blood-brain, blood-spinal cord and blood-cerebrospinal fluid barriers (BBB/BSCB/BCSFB). The CSF analysis is still one of the basic laboratory tools and might reflect pathophysiological alterations in the course of the disease and could provide an insight into disease pathomechanisms. The most important aim of its analysis is evaluation of blood-CSF barrier, which is altered in 46 % of ALS patients. The CSF biomarkers may give insight into ALS pathophysiology and may be useful for early, presymptomatic diagnosis, therapeutic monitoring and the development of new therapeutic strategies. This review summarizes the general concepts of biomarkers in CSF of ALS patients and their potential usefulness in further research.

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“…The elevated CSF levels of 3-NT were reported also in other neurodegenerative disorders such as Parkinson's and Alzheimer's diseases (Aoyama et al 2000;Ryberg et al 2004).…”

Section: Potential Biomarkers Reflecting Oxidative Stress In Csfmentioning

confidence: 77%

CSF markers in amyotrophic lateral sclerosis

et al. 2012

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“…Biochemical measurements of 3-nitrotyrosine and 3-nitro-4-hydroxyphenylacetic acid showed significant increases in the lumbar and thoracic spinal cords of ALS patients. Marked increases of both free 3-nitrotyrosine and nitrated MnSOD in the cerebrospinal fluid of SALS patients have also been reported [125,126].…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 89%

Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview

Mariani

Polidori

Cherubini

et al. 2005

Journal of Chromatography B

608

418

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“…Like lipid peroxidation markers 4-hydroxynonenal and malondialdehyde are identified in the cortex and hippocampus of patients with AD and the substantia nigra of patients with PD [5][6][7][8][9]. Marker of protein oxidation like Protein nitration has been demonstrated to be elevated in the hippocampus and neocortex of individuals with AD and lewy bodies in cases of PD [10][11][12]. Surprisingly, some of these oxidative events look to be reasonably target specific.…”

Section: Introductionmentioning

confidence: 99%