Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

“…Wu et al [24] found that dietary protein supplementation could increase nitric oxide synthesis in the placenta of pigs. Nitric oxide could activate Nrf2 in rat pheochromocytoma cells [25]. These data indicate that there may be a correlation between dietary proteins and the function of the fish intestinal physical barriers associated with TJs, apoptosis and antioxidants as well as their related signalling pathways, which require further investigation.…”

Regulation of pancreatic β-cell survival by nitric oxide

“…114 Several mechanisms have been described for the antiapoptotic actions of NO, such as protein activation by modification of prosthetic groups 102,115 and cysteine modification by S-nitrosylation. 29,111,112,[116][117][118] Both mechanisms can regulate signaling pathways 17,101,102,104 and gene expression. 29,118 Prosthetic group modification is related to the high NO reactivity with metal ions.…”

“…29,111,112,[116][117][118] Both mechanisms can regulate signaling pathways 17,101,102,104 and gene expression. 29,118 Prosthetic group modification is related to the high NO reactivity with metal ions. The activation of guanylate cyclase (GC) is a well-studied example.…”

“…Gene activity may be directly regulated by the cysteine S-nitrosylation of TF or through the destabilization of some components of regulatory complexes. 116,118 In general, the fundamental consequence of direct S-nitrosylation on TFs is the inhibition of DNA-binding capacity, but its effects on the expression of cytoprotective genes have not been clearly studied. Preliminary results from our laboratory show that NO increases the expression of protective genes whose regulatory regions contain binding sites for some TFs with Zn-finger domains.…”

Nitrite Therapy Ameliorates Myocardial Dysfunction via H 2 S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure

“…Nrf2 regulates the gene expression of a number of enzymes that serve to detoxify pro‐oxidative stressors,40 such as glutathione peroxidase (GPX) and HO‐1 by binding to the antioxidant response element found in the gene promoter region 34. In the same regard, there is also evidence that NO possesses antioxidant effects and can activate Nrf2 and HO‐1 41, 42. However, the mechanism by which NO reduces oxidative stress following MI/R remains unknown.…”