Nitric oxide and AQP2 in hypothyroid rats: A link between aging and water homeostasis

Sarati, Lorena Ivonne; Toblli, Jorge Eduardo; Martínez, Carla; Uceda, Ana; Feldman, Mariana Laura; Balaszczuk, Ana M.; Fellet, Andrea L.

doi:10.1016/j.metabol.2013.04.013

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Pu et al found that PTU inhibits the production of aldosterone through the cAMP, Ca 2+ , and steroidogenic enzymes activities in male rats [11]. Hsu et al also found that the release of atrial natriuretic peptide induced by 165 mM of sodium ion decreased in PTU-induced hypothyroid rats [31]. However, surgery or PTU injection had no obvious effects on water consumption or urine output in all groups of the present study (Figure 2d,e).…”

Section: Resultssupporting

confidence: 43%

Effects of Subacute Hypothyroidism on Metabolism and Growth-Related Molecules

et al. 2014

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Thyroid hormones are crucial hormones that primarily regulate the metabolism of entire body cells. In this study, Sprague-Dawley rats were grouped into sham thyroidectomy (Sham Tx), thyroidectomy (Tx), Tx with thyroxine replacement (Tx + T4), and PTU injection (PTU) groups. Metabolic parameters were measured by means of metabolic cages for 14 days. After 14 days, the rats were sacrificed while the levels of plasma or serum TSH and growth-related molecules, such as active and total ghrelin, GH, and IGF-1, were assayed. The results revealed that hypothyroid rats tended to eat less food and experienced substantial body weight gain, whereas the rats with T4 replacement tended to eat more food OPEN ACCESSMolecules 2014, 19 11179 while continuing to lose weight. In hypothyroid rats, the growth-related molecules, such as active ghrelin and total ghrelin secretion, were enhanced, and the ghrelin receptors were also up-regulated. However, circulating GH levels were not elevated and IGF-1 secretion was inhibited in hypothyroid rats. In the Tx + T4 group, the changes of active ghrelin, total ghrelin, GHS-R expression, and IGF-1 were reversed, whereas the GH secretion was higher than that of the Sham Tx group and hypothyroid groups. This study resulted in the novel finding that the ghrelin/GHS-R axis and GH/IGF-1 axis are interrupted in hypothyroid rats.

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Section: Resultssupporting

confidence: 43%

Effects of Subacute Hypothyroidism on Metabolism and Growth-Related Molecules

et al. 2014

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“…On the other hand, with regard to hypothyroidism, results are still inconsistent. Although some studies showed that because of the lower metabolic rate in hypothyroidism, the free radical generation and hence oxidative stress decrease (25, 26), others stated that decreased levels of antioxidants in patients with hypothyroidism cause an increased oxidative stress (20, 27, 28). Baser et al previously showed that compared to healthy controls in the serum of euthyroid Hashimoto patients oxidant status was significantly increased, and positively correlated with the levels of thyroglobulin antibodies (29).…”

Section: Discussionmentioning

confidence: 99%

Alteration in Prooxidant-Antioxidant Balance Associated with Selenium Concentration in Patients with Congenital Hypothyroidism

Rostami

Fathollahpour

Abdi

et al. 2018

Journal of Medical Biochemistry

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SummaryBackground: There is a paucity of studies regarding oxidative balance and selenium (Se) status in congenital hypothyroidism. Recently, more attention has been given to the use of Se supplementation as a new treatment for thyroid disorders. Oxidative stress increases in different thyroid disorders and causes many pathological outcomes. The present study aimed to determine the serum prooxidant-antioxidant balance (PAB), Se, thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentration in congenital hypothyroidism (CH) patients and the association of their probable change with hematological indices. Methods: Blood samples were collected from 60 healthy and 39 CH subjects. Serum PAB values were measured and Se, TSH, FT4 and hematological indices were determined. Data were analyzed by SPSS version 16 and p value less than 0.05 was considered statistically significant. Results: Serum TSH concentration was significantly higher in CH patients group compared to the controls (p value < 0.05); however, FT4 was in the same concentration in patients and controls. Platelet (Plt) and lymphocytes (Lym) counts markedly decreased in all patients and showed a significant direct correlation with serum TSH levels (r s =

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“…Elevated AQP2 in rats with hyperthyroidism was found in the plasma membrane of the young rats and at the cytosolic site in adult rats. These findings showed that medullary NO and AQP2 are implicated in maintaining water homeostasis [210]. Due to the role of the connection of NO-AQP2-hypothyroid damage in the regulation of water homeostasis, it was suggested that hypothyroidism may affect renal parameters in the aging processes.…”

Section: Thyroid Aging and Nomentioning

confidence: 94%

“…AQP2 trafficking to the apical plasma membrane, in medullary duct collection cells, involves NO. Sarati et al (2013) showed that the urine output and medullary NOS activity are correlated reversely in young and old rats, as the former was increased in the young and later was increased in the old rats. Elevated AQP2 in rats with hyperthyroidism was found in the plasma membrane of the young rats and at the cytosolic site in adult rats.…”

Section: Thyroid Aging and Nomentioning

confidence: 97%

An Overview of NO Signaling Pathways in Aging

et al. 2021

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Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechanisms of NO signaling in the cardiovascular system, central nervous system (CNS), reproduction system, as well as its effects on skin, kidneys, thyroid, muscles, and on the immune system during aging. The aging-related decline in NO levels and bioavailability is also discussed in this review. The decreased NO production by endothelial nitric oxide synthase (eNOS) was revealed in the aged cardiovascular system. In the CNS, the decline of the neuronal (n)NOS production of NO was related to the impairment of memory, sleep, and cognition. NO played an important role in the aging of oocytes and aged-induced erectile dysfunction. Aging downregulated NO signaling pathways in endothelial cells resulting in skin, kidney, thyroid, and muscle disorders. Putative therapeutic agents (natural/synthetic) affecting NO signaling mechanisms in the aging process are discussed in the present study. In summary, all of the studies reviewed demonstrate that NO plays a crucial role in the cellular aging processes.

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Nitric oxide and AQP2 in hypothyroid rats: A link between aging and water homeostasis

Cited by 6 publications

References 32 publications

Effects of Subacute Hypothyroidism on Metabolism and Growth-Related Molecules

Effects of Subacute Hypothyroidism on Metabolism and Growth-Related Molecules

Alteration in Prooxidant-Antioxidant Balance Associated with Selenium Concentration in Patients with Congenital Hypothyroidism

An Overview of NO Signaling Pathways in Aging

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