2000
DOI: 10.1161/01.hyp.36.2.264
|View full text |Cite
|
Sign up to set email alerts
|

Nitric Oxide and Cardiac Autonomic Control in Humans

Abstract: Abstract-Cardiac autonomic control is of prognostic significance in cardiac disease, yet the control mechanisms of this system remain poorly defined. Animal data suggest that nitric oxide (NO) modulates cardiac autonomic control. We investigated the influence of NO on the baroreflex control of heart rate in healthy human subjects. In 26 healthy male volunteers (mean age, 23Ϯ5 years), we measured heart rate variability and baroreflex sensitivity during inhibition of endogenous NO production with N G -monomethyl… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

4
107
0
8

Year Published

2001
2001
2022
2022

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 130 publications
(119 citation statements)
references
References 35 publications
4
107
0
8
Order By: Relevance
“…Accordingly, experimental evidence shows that a reduction in prostacyclin, an increase in free oxygen radicals, and the reduced endotheliumdependent synthesis of nitric oxide associated with endothelial dysfunction are all factors that reduce baroreflex sensitivity. 7,19,20 Vitamin C, a potent antioxidant, improves endothelial function. Besides reducing oxidative stress, 17 it acts also to suppress the induction of endothelial cell apoptosis by cytokines, tumor necrosis factor-␣, and angiotensin II.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Accordingly, experimental evidence shows that a reduction in prostacyclin, an increase in free oxygen radicals, and the reduced endotheliumdependent synthesis of nitric oxide associated with endothelial dysfunction are all factors that reduce baroreflex sensitivity. 7,19,20 Vitamin C, a potent antioxidant, improves endothelial function. Besides reducing oxidative stress, 17 it acts also to suppress the induction of endothelial cell apoptosis by cytokines, tumor necrosis factor-␣, and angiotensin II.…”
Section: Discussionmentioning
confidence: 99%
“…18 Regardless of how it acts, by improving endothelial cell function, vitamin C could improve autonomic nervous system control through 2 mechanisms: indirectly, by improving hemodynamics, or directly, by acting on subendothelial nerve endings at the baroreceptor level (carotid, aortic, or cardiopulmonary). Possible support for a direct action comes from the recent observation that endothelium-derived nitric oxide increases vagal activity in patients with CHF 19,20 and that acute infusion of vitamin C influences nitric oxide-mediated vasodilation. 21 Acute administration of vitamin C might therefore improve local nitric oxide production, thus directly stimulating the vagus nerve.…”
mentioning
confidence: 99%
“…Although these small changes may not be of great clinical significance, the fact that heart rate variability also deteriorated with spironolactone treatment makes it unlikely that the worsening of endothelial function is due to chance, since heart rate variability has been shown to be closely associated with nitric oxide activity [35,36].…”
Section: Discussionmentioning
confidence: 99%
“…Conversely, during hypotension resulting from the NO donor sodium nitroprusside, there was relative preservation of indices of vagal activity compared to those produced by an equal fall in blood pressure with the non-NO dependent vasodilator, hydralazine. 93 …”
Section: Journal Of Human Hypertensionmentioning
confidence: 99%