Nitric oxide- and cisplatin-releasing silica nanoparticles for use against non-small cell lung cancer

Munaweera, Imalka; Shi, Yi; Koneru, Bhuvaneswari; Patel, Amit N.; Dang, Mai H.; Pasqua, Anthony J. Di; Balkus, Kenneth J.

doi:10.1016/j.jinorgbio.2015.09.002

Cited by 69 publications

(43 citation statements)

References 75 publications

(95 reference statements)

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“…Such a result will support the idea that induction of a potent anti-tumoral response against NPC may rely in part on the induction of (NO) • synthesis. In case of verification of our hypotheses, future interventional and clinical approaches should take into account the possibility of manipulating the nitrosative stress in-vivo, by directly delivering (NO) • or NOS2 substrate bearing molecules, such as nanoparticles, to the tumor site or to (NO) • producing cells, to increase nitric oxide bioavailability and possibly inhibit NPC metastatic activity and induce tumor cell clearance [62, 63]. …”

Section: Discussionmentioning

confidence: 99%

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

et al. 2015

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The role of nitric oxide (NO)• in the development of the metastatic properties of nasopharyngeal carcinoma (NPC) is not fully understood. Previous studies proposed that interleukin-6 (IL-6) would act as regulator of matrix metalloprotease activation in NPC. Recently, we showed that (NO)• was a critical mediator of tumor growth in patients. The aim of this study was to determine the implication of IL-6 in the progression of NPC pathology via MMPs activation and their possible correlation with (NO)• production. We observed a significant increase in IL-6 and nitrites (NO2−) synthesis in patients (n=17) as well as a strong expression of IL-6 and nitric oxide synthase 2 (NOS2) in the analyzed tumors (n=8). In patients’ plasma, a negative correlation associated IL-6 with circulating nitrites (r=−0.33). A negative correlation associated the H-scores of these signals in the tumors (r=−0.47). In patients’ plasma, nitrites synthesis was positively associated with MMP-9 activation (r=0.45), pro-MMP-2 expression (r=0.37) and negatively correlated with MMP-2 activation (r=−0.51). High nitrite levels was associated with better recurrence free survival RFS (p=0.02). Overall our results suggest that the IL-6/NOS2 inflammatory signals are involved in the regulation of MMP-9 and MMP-2 dependent metastatic activity, and that high circulating nitrite levels in NPC patients may constitute a prognostic predictor for survival.

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Section: Discussionmentioning

confidence: 99%

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

et al. 2015

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“…It is noteworthy that the additive cytotoxic effects of NO did not significantly affect normal cells (H9c2 rat cardiomyoblast), implying that the potential applications of combined NO and drug delivery are conducive for tumor cell selective therapy. Balkus Jr. et al employed a similar strategy in the synthesis of a silica based nanoparticle formulation [68]. They prepared amine-modified mesoporous silica nanoparticles (MSN), followed by loading of cisplatin and modification with diazeniumdiolate.…”

Section: Progress Of Combined No and Drug Delivery Systemsmentioning

confidence: 99%

“…In addition, the ability of the combined NO and drug delivery systems in overcoming MDR can be exhibited after their efficient accumulation at the target sites. The combined NO and drug delivery systems are expected to provide a solution to resolve this problem because NO has potential in increasing tumor perfusion, which can improve the enhanced permeation and retention (EPR) effect that allows macromolecules to penetrate leaky tumor blood vessels surrounding solid tumor [68,79]. In conclusion, the continuing endeavor to surmount these challenges will pave the way for achieving clinical applications of the combined NO and drug delivery system to enhance chemotherapy.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy

Kim

Yung

Kim

et al. 2017

Journal of Controlled Release

173

119

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Chemotherapeutic drugs have made significant contributions to anticancer therapy, along with other therapeutic methods including surgery and radiotherapy over the past century. However, multidrug resistance (MDR) of cancer cells has remained as a significant obstacle in the achievement of efficient chemotherapy. Recently, there has been increasing evidence for the potential function of nitric oxide (NO) to overcome MDR. NO is an endogenous and biocompatible molecule, contrasting with other potentially toxic chemosensitizing agents that reverse MDR effects, which has raised expectations in the development of efficient therapeutics with low side effects. In particular, nanoparticle-based drug delivery systems not only facilitate the delivery of multiple therapeutic agents, but also help bypass MDR pathways, which are conducive for the efficient delivery of NO and anticancer drugs, simultaneously. Therefore, this review will discuss the mechanism of nitric oxide (NO) in overcoming MDR and recent progress of combined NO and drug delivery systems.

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“…Huang et al used mesoporous silica nanoparticles as carriers with a high density of carboxylic groups inside their mesopores to load hydrophilic Pt II drugs through chelation . A similar strategy has been followed by Lv et al who tested mercaptopurine‐modified mesoporous silica nanoparticles as nanocarriers of cisplatin, and by Balkus and co‐workers who designed nitric‐oxide‐ and cisplatin‐releasing wrinkle‐structured amine‐modified mesoporous silica nanoparticles . A more sophisticated system has been published by Mohapatra et al who synthesized hollow mesoporous silica nanospheres; the exterior was selectively functionalized with carboxylic groups to conjugate cisplatin, folic acid and rhodamine isothiocyanate, whereas the interior space was used to encapsulate superparamagnetic nanoparticles as well as the hydrophobic anticancer drug pemetrexed .…”

Section: Introductionmentioning

confidence: 99%

Pt and Ti Complexes Immobilized onto Mesoporous Silica Microspheres and Their Interaction with Molecules of Biological Interest

et al. 2017

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Mesoporous silica microspheres (MSMs) have been functionalized with triazole and pendant hydroxy moieties by a postsynthetic procedure. The functionalities have been prepared by a very efficient azide/alkyne click reaction with propargyl alcohol to yield the corresponding 1,2,3‐triazole. The subsequent reaction with cisplatin and titanocene as metallic precursors produces platinum and titanium complexes tethered onto the silica surface. The synthesized materials have been fully characterized by dynamic recrystallization kinetics (DRX), FTIR, N2 adsorption/desorption techniques, TEM, diffuse reflectance (DR) UV/Vis and 13C cross polarization/magic angle spinning (CP/MAS) NMR spectroscopy. In addition, the interaction of these materials with molecules of biological interest such as guanosine and bovine serum albumin has been studied by means of solid‐state voltammetry techniques. Drug‐release experiments in simulated body fluid show sustained release profiles for the platinum complexes.

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Nitric oxide- and cisplatin-releasing silica nanoparticles for use against non-small cell lung cancer

Cited by 69 publications

References 75 publications

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy

Pt and Ti Complexes Immobilized onto Mesoporous Silica Microspheres and Their Interaction with Molecules of Biological Interest

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