2004
DOI: 10.1111/j.1399-0012.2004.00210
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Nitric oxide attenuates ischaemia‐reperfusion (I/R) injury in the diabetic liver

Abstract: This is the first study suggesting that DM exacerbates hepatic I/R and that NO donors will prevent this hepatocellular injury in the diabetic. Sixteen million Americans have DM. Understanding the effect of this chronic illness on the inflammatory response to injury is essential to improving clinical outcomes in these medically compromised patients.

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Cited by 9 publications
(5 citation statements)
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“…If there are too many fats present, and after they are initially consumed by the periportal and midzonal hepatocytes, the rest of fat is consumed by the centrilobular hepatocytes with centrilobular steatosis development (7,8). Additionally, toxicology studies show the importance of blood fl ow across liver (9,10). This interpretation demonstrates that a toxic substance fi rst brought into contact with periportal hepatocytes, afterwards with midzonal and at last with centrilobular hepatocytes.…”
Section: Discussionmentioning
confidence: 99%
“…If there are too many fats present, and after they are initially consumed by the periportal and midzonal hepatocytes, the rest of fat is consumed by the centrilobular hepatocytes with centrilobular steatosis development (7,8). Additionally, toxicology studies show the importance of blood fl ow across liver (9,10). This interpretation demonstrates that a toxic substance fi rst brought into contact with periportal hepatocytes, afterwards with midzonal and at last with centrilobular hepatocytes.…”
Section: Discussionmentioning
confidence: 99%
“…(13,34,55,57,65) More recent studies demonstrate that animals and humans are capable of producing substantial quantities of NO via eNOS- independent pathways that utilize nitrogen oxides that are produced from the decomposition of NO or are ingested in the diet. Like any important signaling molecule, the generation and lifetime of NO is very short-lived in vivo .…”
Section: Suppression Of I/r-induced Liver Damage By Endogenous or Exomentioning
confidence: 99%
“…PEG35 also increases NO production, a key player in vasodilation [ 18 ]. NO production improves microcirculation within the graft, therefore decreasing reperfusion injury [ 19 , 20 ]. For this reason, IGL-1 is positioned as an excellent alternative to UW as it overcomes one of its main limitations.…”
Section: Introductionmentioning
confidence: 99%