Nitric Oxide Concentrations in Saliva and Dental Plaque in Relation to Caries Experience and Oral Hygiene

Bayindir, Yusuf Ziya; Polat, Murat; Seven, Nilgün

doi:10.1159/000083158

Cited by 41 publications

(39 citation statements)

References 32 publications

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“…14,15 In this sense, an increase in the TAC of saliva could produce modifications in the adherence of Streptococcus to the den tal plaque and lead to greater cariogenic activity. Several authors 16 have reported greater activity in prooxidant molecules such as nitric oxide (NO) in the saliva of subjects with dental caries. Raised levels of NO in subjects with caries and poor oral hygiene would be a defence mecha nism against increased bacterial activity in the mouth.…”

Section: Discussionmentioning

confidence: 99%

Influence of the antioxidant content of saliva on dental caries in an at-risk community

et al. 2008

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• The amount of caries in deciduous teeth is in direct proportion to the observed antioxidant capacity of saliva.• The total antioxidant capacity of saliva is greater among children that have caries.• The presencce of caries in deciduous teeth is associated with caries in permanent teeth. I N B R I E F RESEARCHObjective This study aims to evaluate the relationship between the total antioxidant capacity of saliva and the presence of dental caries in deciduous and permanent teeth, in a group of Saharan children. Methods The dental examination was carried out in accordance with the recommendations of the World Health Organization (WHO). The total antioxidant capacity of the saliva was determined by colorimetry. Results The total antioxidant capacity (TAC) of the saliva of patients with caries in deciduous teeth was 2.89 1/IC50 greater than among those without. We observed a statistically signifi cant linear regression between the number of deciduous teeth affected by caries and the total antioxidant capacity of the saliva: y = 0.24 + 0.53 × TAC saliva (t = 2.93; p = 0.004) (95% CI of b: 0.018-0.088). Conclusions Our results show that the amount of caries in deciduous teeth is in direct proportion to the observed TAC of saliva, and that the presence of caries in deciduous teeth is associated with caries in permanent teeth.

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Section: Discussionmentioning

confidence: 99%

Influence of the antioxidant content of saliva on dental caries in an at-risk community

et al. 2008

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“…Inducible NOS (iNOS) is produced by macrophages that are stimulated by inflammatory cytokines, such as TNF-α, IL-1, and IFN-γ; these cytokines are able to produce NO (38). Salivary NO can be produced from free nerve endings, secretory cells in the salivary gland, salivary gland endothelial cells, and bacteria in the oral cavity (39). Salivary glands and oral microbiota play an essential role in the conversion of NO 3 − and NO 2 − to NO.…”

Section: Nitric Oxidementioning

confidence: 99%

Role of oral and gut microbiome in nitric oxide-mediated colon motility

et al. 2018

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Periodontal disease (PD), a severe form of gum disease, is among the most prevalent chronic infection in humans and is associated with complex microbial synergistic dysbiosis in the subgingival cavity. The immune system of the body interacts with the microbes as the plaque extends and propagates below the gingival sulcus. Once bacteria reach the gingival sulcus, it can enter the blood stream and affect various areas of the human body. The polymicrobial nature of periodontal disease, if left untreated, promotes chronic inflammation, not only within the oral cavity, but also throughout the human body. Alterations seen in the concentrations of healthy gut microbiota may lead to systemic alterations, such as gut motility disorders, high blood pressure, and atherosclerosis. Although gut microbiome has been shown to play a vital role in intestinal motility functions, the role of oral bacteria in this setting remains to be investigated. It is unclear whether oral microbial DNA is present in the large intestine and, if so, whether it alters the gut microbiome. In addition, polybacterial infection induced PD reduced nitric oxide (NO) synthesis and antioxidant enzymes in rodent colon. In this review, we will discuss the interactions between oral and gut microbiome, specifics of how the oral microbiome may modulate the activities of the gut microbiome, and possible ramifications of these alterations.

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“…Therefore, the microbes that survive in the deeper parts of the biofilm are facultative anaerobes. This would be the reason why nitrogen oxides are significantly higher in poor oral hygiene individuals than those with good oral hygiene who have thinner dental biofilm [22]. Many anaerobic facultative bacteria synthesize nitrate reductase in low oxygen tension [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], hence, reduction can take place in the thick biofilm or deep tongue crypts [23].…”

Section: Denitrification Effect On Dental Caries Formationmentioning

confidence: 99%

“…It was reported that pH below 7 would promote the conversion of L-arginine to NO and its compounds [25]. NO is one of the byproducts and it is recognized for its antibacterial effect that inhibit the acidogenic bacteria which are responsible for caries formation [22,26]. Nitric oxide antibacterial effects are thought to include DNA modifications and interactions with other reactive species; for example, reaction with superoxide produces the highly reactive molecule peroxynitrite [27].…”

Section: Denitrification Effect On Dental Caries Formationmentioning

confidence: 99%

“…Nitric oxide antibacterial effects are thought to include DNA modifications and interactions with other reactive species; for example, reaction with superoxide produces the highly reactive molecule peroxynitrite [27]. Therefore, nitrate recycling and the availability of large amounts of nitrite in the oral cavity would result in bacteriostatic and possibly bacteriocidal effects which subsequently limit the survival of acidogenic bacteria and decrease caries formation [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: Denitrification Effect On Dental Caries Formationmentioning

confidence: 99%

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The Role of Nuclear Factor Kappa B in Periodontal Diseases

Younis¹

2017

JDHODT

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Periodontal (gum) diseases are inflammatory conditions caused by microbial dental biofilm. Chronic periodontitis is the most common form of the periodontal diseases result in loss of connective tissue attachment and supporting bone that may eventually result in loss of teeth. Nuclear factor kappa B (NF-kB) is a key regulator during inflammatory process involving the gingiva and alveolar bone of teeth. In this paper, we explain the role of NF-kB in the destructive process of teeth supporting tissues.

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Nitric Oxide Concentrations in Saliva and Dental Plaque in Relation to Caries Experience and Oral Hygiene

Cited by 41 publications

References 32 publications

Influence of the antioxidant content of saliva on dental caries in an at-risk community

Influence of the antioxidant content of saliva on dental caries in an at-risk community

Role of oral and gut microbiome in nitric oxide-mediated colon motility

The Role of Nuclear Factor Kappa B in Periodontal Diseases

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