Nitric Oxide Diffusion Rate is Reduced in the Aortic Wall

Liu, Xiaoping; Collard, Eric; Grajdeanu, Paula; Zweíer, Jay L.; Friedman, Avner

doi:10.1529/biophysj.107.120626

Cited by 41 publications

(31 citation statements)

References 52 publications

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“…where c w is the concentration of NO in the arterial wall, D w the diffusivity of NO in the arterial wall (8.48 Â 10 210 m 2 s 21 ) and _ V w the reaction rate of NO [31]. The reaction rate is treated as a first-order rate expression, which is given by [32] …”

Section: Geometry Of the Modelmentioning

confidence: 99%

Nitric oxide transport in an axisymmetric stenosis

Liu

Fan

et al. 2012

J. R. Soc. Interface.

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To test the hypothesis that disturbed flow can impede the transport of nitric oxide (NO) in the artery and hence induce atherogenesis, we used a lumen -wall model of an idealized arterial stenosis with NO produced at the blood vessel -wall interface to study the transport of NO in the stenosis. Blood flows in the lumen and through the arterial wall were simulated by Navier -Stokes equations and Darcy's Law, respectively. Meanwhile, the transport of NO in the lumen and the transport of NO within the arterial wall were modelled by advection -diffusion reaction equations. Coupling of fluid dynamics at the endothelium was achieved by the Kedem -Katchalsky equations. The results showed that both the hydraulic conductivity of the endothelium and the non-Newtonian viscous behaviour of blood had little effect on the distribution of NO. However, the blood flow rate, stenosis severity, red blood cells (RBCs), RBC-free layer and NO production rate at the blood vessel -wall interface could significantly affect the transport of NO. The theoretical study revealed that the transport of NO was significantly hindered in the disturbed flow region distal to the stenosis. The reduced NO concentration in the disturbed flow region might play an important role in the localized genesis and development of atherosclerosis.

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Section: Geometry Of the Modelmentioning

confidence: 99%

Nitric oxide transport in an axisymmetric stenosis

Liu

Fan

et al. 2012

J. R. Soc. Interface.

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“…Factors that limit nitric oxide diffusion and therefore its half-life in biological systems include its interactions with soluble guanylyl cyclase and other proteins (e.g., hemoglobin), lipids and free radicals [11–13]. When measured in isolated rat aorta, for example, its diffusion was shown to be four-fold smaller in an aortic wall than that in a homogeneous medium such as water [14]. It has also recently been reported that the cholesterol content in membranes decreases nitric oxide diffusion by 20 to 40% [12].…”

Section: Introductionmentioning

confidence: 99%

Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease

Villanueva

Giulivi

2010

Free Radical Biology and Medicine

192

127

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The effects of nitric oxide in biological systems depend on its steady-state concentration and where it is being produced. The organ where nitric oxide is produced is relevant, and within the organ, which types of cells are actually contributing to this production seem to play a major determinant of its effect. Subcellular compartmentalization of specific nitric-oxide synthase enzymes has been shown to play a major role in health and disease. Pathophysiological conditions affect the cellular expression and localization of nitric oxide synthases, which in turn alter organ cross talk. In this study, we described the compartmentalization of nitric oxide in organs, cells and subcellular organelles, and how its localization relates to several relevant clinical conditions. Understanding the complexity of the compartmentalization of nitric oxide production and the implications of this compartmentalization in terms of cellular targets and downstream effects will eventually contribute toward the development of better strategies for treating or preventing pathological events associated with the increase, inhibition or mislocalization of nitric oxide production.

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“…also demonstrated NOS activity in the larval midgut of L. pictus by NADPHdiaphorase staining. NO is also known to diffuse easily through membranes and into neighboring cells (Snyder 1992;Liu et al 2008), and to play other physiological roles in annelids besides regulating metamorphosis. Licata et al (2002) showed that NO regulates tissue homeostasis and salt-water balance in the epidermis of the earthworm Lumbricus terrestris, and endothelial NOS plays a role in repair of the nervous system in leeches (Shafer et al 1998) as well as in neurotransmission in the ventral nerve cord in the earthworm Eisenia fetida (Kitamura et al 2001).…”

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confidence: 99%